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Structure−Activity Relationships of Polymyxin Antibiotics

Journal of medicinal chemistry, 2010-03, Vol.53 (5), p.1898-1916

2010

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The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

Cell, 2016-06, Vol.165 (7), p.1632-1643

2016

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A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

Nature communications, 2022-03, Vol.13 (1), p.1625-15, Article 1625

2022

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Aqueous extracts of Urtica dioica (stinging nettle) leaf contain a P2-purinoceptor antagonist—Implications for male fertility

PloS one, 2022-07, Vol.17 (7), p.e0271735

2022

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IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

Frontiers in pharmacology, 2020-09, Vol.11, p.585930-585930

2020

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A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

Journal of antibiotics, 2014-02, Vol.67 (2), p.147-151

2014

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Structural Determinants of Isoform Selectivity in PI3K Inhibitors

Biomolecules (Basel, Switzerland), 2019-02, Vol.9 (3), p.82

2019

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The Phytosulfokine (PSK) Receptor Is Capable of Guanylate Cyclase Activity and Enabling Cyclic GMP-dependent Signaling in Plants

The Journal of biological chemistry, 2011-06, Vol.286 (25), p.22580-22588

2011

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Parallel and antiparallel cyclic d/l peptide nanotubes

Chemical communications (Cambridge, England), 2017-06, Vol.53 (49), p.6613-6616

2017

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A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii

Chemical science (Cambridge), 2021-09, Vol.12 (36), p.12211-12220

2021

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Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-Line Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

ACS infectious diseases, 2015-11, Vol.1 (11), p.568-575

2015

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Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401

Journal of natural products (Washington, D.C.), 2017-05, Vol.80 (5), p.1264-1274

2017

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Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines

European journal of medicinal chemistry, 2016-03, Vol.110, p.326-339

2016

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Molecular Mechanisms of Cereblon-Interacting Small Molecules in Multiple Myeloma Therapy

Journal of personalized medicine, 2021-11, Vol.11 (11), p.1185

2021

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Defeating MYC with drug combinations or dual-targeting drugs

Trends in pharmacological sciences (Regular ed.), 2024-06, Vol.45 (6), p.490-502

2024

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major human and mouse granzymes are structurally and functionally divergent

The Journal of cell biology, 2006-11, Vol.175 (4), p.619-630

2006

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An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients

BMC biology, 2022-03, Vol.20 (1), p.73-73, Article 73

2022

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Design and Evaluation of Novel Polymyxin Fluorescent Probes

Sensors (Basel, Switzerland), 2017-11, Vol.17 (11), p.2598

2017

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The Next Generation of Phosphodiesterase Inhibitors: Structural Clues to Ligand and Substrate Selectivity of Phosphodiesterases

Journal of medicinal chemistry, 2005-05, Vol.48 (10), p.3449-3462

2005

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TNP Analogues Inhibit the Virulence Promoting IP3-4 Kinase Arg1 in the Fungal Pathogen Cryptococcus neoformans

Biomolecules (Basel, Switzerland), 2022-10, Vol.12 (10), p.1526

2022

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Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells

Antibiotics (Basel), 2023-02, Vol.12 (2), p.415

2023

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Pharmacology of polymyxins: new insights into an 'old class of antibiotics

Future microbiology, 2013-06, Vol.8 (6), p.711-724

2013

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Design, Development, In Vitro and Preliminary In Vivo Evaluation of a Novel Photo-Angioplasty Device: Lumi-Solve

Cardiovascular engineering and technology, 2021-08, Vol.12 (4), p.466-473

2021

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Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin–lipopolysaccharide binding interactions

Analytical biochemistry, 2011-02, Vol.409 (2), p.273-283

2011

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Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis

Biochemical journal, 2012-06, Vol.444 (3), p.529-535

2012

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Structure−Activity Relationships of Polymyxin Antibiotics

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

Aqueous extracts of Urtica dioica (stinging nettle) leaf contain a P2-purinoceptor antagonist—Implications for male fertility

IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

Structural Determinants of Isoform Selectivity in PI3K Inhibitors

The Phytosulfokine (PSK) Receptor Is Capable of Guanylate Cyclase Activity and Enabling Cyclic GMP-dependent Signaling in Plants

Parallel and antiparallel cyclic d/l peptide nanotubes

A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-Line Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401

Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines

Molecular Mechanisms of Cereblon-Interacting Small Molecules in Multiple Myeloma Therapy

Defeating MYC with drug combinations or dual-targeting drugs

major human and mouse granzymes are structurally and functionally divergent

An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients

Design and Evaluation of Novel Polymyxin Fluorescent Probes

The Next Generation of Phosphodiesterase Inhibitors: Structural Clues to Ligand and Substrate Selectivity of Phosphodiesterases

TNP Analogues Inhibit the Virulence Promoting IP3-4 Kinase Arg1 in the Fungal Pathogen Cryptococcus neoformans

Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells

Pharmacology of polymyxins: new insights into an 'old class of antibiotics

Design, Development, In Vitro and Preliminary In Vivo Evaluation of a Novel Photo-Angioplasty Device: Lumi-Solve

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin–lipopolysaccharide binding interactions

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis

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