UB Paderborn / Katalog / Suche / in CDI

Sortiert nach

Einfacher Volltextzugriff von (fast) überall

Installieren Sie die LibKey Nomad-Browsererweiterung und erhalten Sie von vielen Webseiten einfachen Zugriff auf lizenzierte Volltexte oder Open Access Publikationen. Mehr erfahren...

Phase 1 clinical trial of losmapimod in facioscapulohumeral dystrophy: Safety, tolerability, pharmacokinetics, and target engagement

British journal of clinical pharmacology, 2021-12, Vol.87 (12), p.4658-4669

2021

Volltextzugriff (PDF)

p38 α Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular Dystrophy

The Journal of pharmacology and experimental therapeutics, 2020-09, Vol.374 (3), p.489-498

2020

Volltextzugriff (PDF)

Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (22), p.127530, Article 127530

2020

Volltextzugriff (PDF)

Recent applications of polymer-supported reagents and scavengers in combinatorial, parallel, or multistep synthesis

Current Opinion in Chemical Biology, 2000-06, Vol.4 (3), p.324-337

Thompson, Lorin A

2000

Volltextzugriff (PDF)

Expedient Synthesis of Furo[2,3-d][1,3]thiazinamines and Pyrano[2,3‑d][1,3]thiazinamines from Enones and Thiourea

Journal of organic chemistry, 2016-04, Vol.81 (8), p.3386-3390

2016

Volltextzugriff (PDF)

Synthesis and Applications of Small Molecule Libraries

Chemical reviews, 1996-01, Vol.96 (1), p.555-600

1996

Volltextzugriff (PDF)

Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2513-2525

2017

Volltextzugriff (PDF)

Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators

Bioorganic & medicinal chemistry letters, 2016-03, Vol.26 (6), p.1554-1557

2016

Volltextzugriff (PDF)

Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9208-9223

2012

Volltextzugriff (PDF)

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

The Journal of pharmacology and experimental therapeutics, 2016-07, Vol.358 (1), p.138

2016

Volltextzugriff (PDF)

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain

Journal of medicinal chemistry, 2019-01, Vol.62 (2), p.831-856

2019

Volltextzugriff (PDF)

Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice

The Journal of neuroscience, 2015-04, Vol.35 (17), p.6931-6936

2015

Volltextzugriff (PDF)

Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22), p.5040-5047

2015

Volltextzugriff (PDF)

Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors

Bioorganic & medicinal chemistry letters, 2018-03, Vol.28 (5), p.958-962

2018

Volltextzugriff (PDF)

Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors

Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (4), p.659-663

2019

Volltextzugriff (PDF)

Discovery of S3-Truncated, C‑6 Heteroaryl Substituted Aminothiazine β‑Site APP Cleaving Enzyme‑1 (BACE1) Inhibitors

Journal of medicinal chemistry, 2016-09, Vol.59 (18), p.8593-8600

2016

Volltextzugriff (PDF)

Correction to Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na V 1.7 Inhibitors for the Treatment of Pain

Journal of medicinal chemistry, 2019-02, Vol.62 (4), p.2213-2213

2019

Volltextzugriff (PDF)

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na V 1.7 Inhibitors for the Treatment of Pain

Journal of medicinal chemistry, 2019-01, Vol.62 (2), p.831-856

2019

Volltextzugriff (PDF)

Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (22), p.6916-6924

2011

Volltextzugriff (PDF)

Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation

Bioorganic & medicinal chemistry, 2017-10, Vol.25 (20), p.5490-5505

2017

Volltextzugriff (PDF)

Preclinical Characterization of ( R )-3-((3 S ,4 S )-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N -Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder

The Journal of pharmacology and experimental therapeutics, 2017-12, Vol.363 (3), p.377-393

2017

Volltextzugriff (PDF)

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

The Journal of pharmacology and experimental therapeutics, 2016-07, Vol.358 (1), p.125

2016

Volltextzugriff (PDF)

Synergistic inhibition of Aβ production by combinations of γ-secretase modulators

European journal of pharmacology, 2017-10, Vol.812, p.104-112

2017

Volltextzugriff (PDF)

Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (23), p.5729-5731

2016

Volltextzugriff (PDF)

Discovery of morpholine-based aryl sulfonamides as Na v 1.7 inhibitors

Bioorganic & medicinal chemistry letters, 2018-03, Vol.28 (5), p.958-962

2018

Volltextzugriff (PDF)

1 – 25 von 121

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(97)
Mit Volltextzugriff
(96)

Publikationsform

Sprache

Englisch
(121)

Erscheinungsjahr

n.n

Neu hinzugefügt

... seit 90 Tagen
(1)

Menü

Weitere Dienste

Einstellungen

Phase 1 clinical trial of losmapimod in facioscapulohumeral dystrophy: Safety, tolerability, pharmacokinetics, and target engagement

p38 α Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular Dystrophy

Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite

Recent applications of polymer-supported reagents and scavengers in combinatorial, parallel, or multistep synthesis

Expedient Synthesis of Furo[2,3-d][1,3]thiazinamines and Pyrano[2,3‑d][1,3]thiazinamines from Enones and Thiourea

Synthesis and Applications of Small Molecule Libraries

Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain

Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators

Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain

Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice

Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors

Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors

Discovery of S3-Truncated, C‑6 Heteroaryl Substituted Aminothiazine β‑Site APP Cleaving Enzyme‑1 (BACE1) Inhibitors

Correction to Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na V 1.7 Inhibitors for the Treatment of Pain

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na V 1.7 Inhibitors for the Treatment of Pain

Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)

Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation

Preclinical Characterization of ( R )-3-((3 S ,4 S )-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N -Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

Synergistic inhibition of Aβ production by combinations of γ-secretase modulators

Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors

Discovery of morpholine-based aryl sulfonamides as Na v 1.7 inhibitors

Suchergebnisse filtern