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Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase

Biophysical journal, 2016-05, Vol.110 (9), p.2106-2119

2016

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Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression

Clinical cancer research, 2018-10, Vol.24 (19), p.4798-4807

2018

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Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models

Molecular cancer therapeutics, 2010-11, Vol.9 (11), p.3052-3064

2010

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Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment

BioMed research international, 2014-01, Vol.2014, p.817613-15

2014

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Therapeutic targeting of hyaluronan in the tumor stroma

Cancers, 2012-09, Vol.4 (3), p.873-903

2012

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Response to Chauhan et al.: Interstitial Pressure and Vascular Collapse in Pancreas Cancer—Fluids and Solids, Measurement and Meaning

Cancer cell, 2014-07, Vol.26 (1), p.16-17

2014

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Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

Gut, 2013-01, Vol.62 (1), p.112-120

2013

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Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance

Diabetes (New York, N.Y.), 2013-06, Vol.62 (6), p.1888-1896

2013

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Targeting hyaluronan accumulation in the tumor microenvironment

Oncotarget, 2018-12, Vol.9 (100), p.37349-37351

2018

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Recombinant human hyaluronidase PH20 does not stimulate an acute inflammatory response and inhibits lipopolysaccharide-induced neutrophil recruitment in the air pouch model of inflammation

The Journal of immunology (1950), 2014-06, Vol.192 (11), p.5285-5295

2014

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Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors

Cancer immunology research, 2015-09, Vol.3 (9), p.1096-1107

2015

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Abstract 2463: PEGPH20 increases the anticancer activity of standard chemotherapy combinations, vincristine (VIN) and D actinomycin (DACT), in a Wilms’ xenograft model

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2463-2463

2016

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Effective Targeting of the Tumor Microenvironment for Cancer Therapy

Anticancer research, 2012-04, Vol.32 (4), p.1203-1212

2012

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Abstract 4886: PEGylated recombinant hyaluronidase PH20 (PEGPH20) enhances checkpoint inhibitor efficacy in syngeneic mouse models of cancer

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4886-4886

2016

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Abstract 283: PEGylated recombinant hyaluronidase PH20 (PEGPH20) enhances pemetrexed antitumor efficacy in a human nonsquamous NSCLC xenograft model

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.283-283

2016

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Skeletal muscle regulates extracellular potassium

American journal of physiology. Renal physiology, 2002-06, Vol.282 (6), p.F967-F974

2002

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Abstract 2206: Degradation of hyaluronan in the tumor microenvironment enhances oncolytic reovirus and anti-PD-L1 therapy in a murine syngeneic breast tumor model

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2206-2206

2020

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Abstract 641: PEGylated recombinant hyaluronidase PH20 (PEGPH20) enhances tumor infiltrating CD8+ T cell accumulation and improves checkpoint inhibitor efficacy in murine syngeneic breast cancer models

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.641-641

2017

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Abstract 2740: PEGylated recombinant hyaluronidase PH20 (pegvorhyaluronidase alfa PEGPH20) converts HA-rich tumors from resistant to sensitive to anti-PD-L1 immunotherapy in murine syngeneic breast cancer models

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2740-2740

2018

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Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clamp

American journal of physiology. Renal physiology, 2001-01, Vol.280 (1), p.F95-F102

2001

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Abstract 1743: Rationale for evaluating PEGylated recombinant human hyaluronidase PH20 (pegvorhyaluronidase alfa; PEGPH20) in patients with hyaluronan (HA)-accumulating colorectal cancer

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1743-1743

2018

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Abstract 1747: Hyaluronan (HA) accumulation restricts CD8+ T cell numbers and skews tumor-associated macrophage (TAM) phenotype in mouse syngeneic pancreatic tumors

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1747-1747

2018

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Abstract LB-198: Combination of PEGylated recombinant hyaluronidase PH20 (PEGPH20) with live-attenuated, double-deleted (LADD) Listeria enhances tumor infiltrating CD8+ T cell response and antitumor efficacy in mice

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.LB-198-LB-198

2017

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Abstract 1240: Evaluating clinically relevant pharmacological agents in a rat ambulation model to ameliorate PEGylated recombinant hyaluronidase PH20 (PEGPH20)-mediated musculoskeletal adverse events

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1240-1240

2017

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Abstract 3036: PEGylated hyaluronidase increases tumor uptake of 89Zr-DFO-HuMab-5B1 (MVT-2163) in a CA19-9 positive hyaluronan-accumulating pancreatic cancer model

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3036-3036

2018

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Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase

Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression

Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models

Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment

Therapeutic targeting of hyaluronan in the tumor stroma

Response to Chauhan et al.: Interstitial Pressure and Vascular Collapse in Pancreas Cancer—Fluids and Solids, Measurement and Meaning

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance

Targeting hyaluronan accumulation in the tumor microenvironment

Recombinant human hyaluronidase PH20 does not stimulate an acute inflammatory response and inhibits lipopolysaccharide-induced neutrophil recruitment in the air pouch model of inflammation

Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors

Abstract 2463: PEGPH20 increases the anticancer activity of standard chemotherapy combinations, vincristine (VIN) and D actinomycin (DACT), in a Wilms’ xenograft model

Effective Targeting of the Tumor Microenvironment for Cancer Therapy

Abstract 4886: PEGylated recombinant hyaluronidase PH20 (PEGPH20) enhances checkpoint inhibitor efficacy in syngeneic mouse models of cancer

Abstract 283: PEGylated recombinant hyaluronidase PH20 (PEGPH20) enhances pemetrexed antitumor efficacy in a human nonsquamous NSCLC xenograft model

Skeletal muscle regulates extracellular potassium

Abstract 2206: Degradation of hyaluronan in the tumor microenvironment enhances oncolytic reovirus and anti-PD-L1 therapy in a murine syngeneic breast tumor model

Abstract 641: PEGylated recombinant hyaluronidase PH20 (PEGPH20) enhances tumor infiltrating CD8+ T cell accumulation and improves checkpoint inhibitor efficacy in murine syngeneic breast cancer models

Abstract 2740: PEGylated recombinant hyaluronidase PH20 (pegvorhyaluronidase alfa PEGPH20) converts HA-rich tumors from resistant to sensitive to anti-PD-L1 immunotherapy in murine syngeneic breast cancer models

Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clamp

Abstract 1743: Rationale for evaluating PEGylated recombinant human hyaluronidase PH20 (pegvorhyaluronidase alfa; PEGPH20) in patients with hyaluronan (HA)-accumulating colorectal cancer

Abstract 1747: Hyaluronan (HA) accumulation restricts CD8+ T cell numbers and skews tumor-associated macrophage (TAM) phenotype in mouse syngeneic pancreatic tumors

Abstract LB-198: Combination of PEGylated recombinant hyaluronidase PH20 (PEGPH20) with live-attenuated, double-deleted (LADD) Listeria enhances tumor infiltrating CD8+ T cell response and antitumor efficacy in mice

Abstract 1240: Evaluating clinically relevant pharmacological agents in a rat ambulation model to ameliorate PEGylated recombinant hyaluronidase PH20 (PEGPH20)-mediated musculoskeletal adverse events

Abstract 3036: PEGylated hyaluronidase increases tumor uptake of 89Zr-DFO-HuMab-5B1 (MVT-2163) in a CA19-9 positive hyaluronan-accumulating pancreatic cancer model

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