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Cardiac Sarcomere Signaling in Health and Disease

International journal of molecular sciences, 2022-12, Vol.23 (24), p.16223

2022

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Inducing positive inotropy in human iPSC-derived cardiac muscle by gene editing-based activation of the cardiac α-myosin heavy chain

Scientific reports, 2024-02, Vol.14 (1), p.3915-3915, Article 3915

2024

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Sarcomere dynamics revealed by a myofilament integrated FRET-based biosensor in live skeletal muscle fibers

Scientific reports, 2022-10, Vol.12 (1), p.18116-18116, Article 18116

2022

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Fatty acid flux in adipocytes: The in's and out's of fat cell lipid trafficking

Molecular and cellular endocrinology, 2010-04, Vol.318 (1), p.24-33

2010

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Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers

Skeletal muscle, 2023-05, Vol.13 (1), p.9-9, Article 9

2023

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Molecular Determinants of Cardiac Myocyte Performance as Conferred by Isoform-Specific TnI Residues

Biophysical journal, 2014-05, Vol.106 (10), p.2105-2114

2014

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Functional Equivalence of Retroviral MA Domains in Facilitating Psi RNA Binding Specificity by Gag

Viruses, 2016-09, Vol.8 (9), p.256

2016

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Pharmacokinetics of gemcitabine and its amino acid ester prodrug following intravenous and oral administrations in mice

Biochemical pharmacology, 2020-10, Vol.180, p.114127-114127, Article 114127

2020

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Interrogation of skeletal muscle activation in an intact system via a myofilament incorporated FRET biosensor

Biophysical journal, 2023-02, Vol.122 (3), p.28a-28a

2023

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Mechanisms of gemcitabine oral absorption as determined by in situ intestinal perfusions in mice

Biochemical pharmacology, 2019-10, Vol.168, p.57-64

2019

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Advancing physiological maturation in human induced pluripotent stem cell‐derived cardiac muscle by gene editing an inducible adult troponin isoform switch

Stem cells (Dayton, Ohio), 2020-10, Vol.38 (10), p.1254-1266

2020

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Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice

Developmental cell, 2021-08, Vol.56 (15), p.2252-2266.e6

2021

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Physiologically-Based Pharmacokinetic Modeling to Predict Methylphenidate Exposure Affected by Interplay Among Carboxylesterase 1 Pharmacogenetics, Drug-Drug Interactions, and Sex

Journal of pharmaceutical sciences, 2022-09, Vol.111 (9), p.2606-2613

2022

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Sarcomere integrated biosensor detects myofilament-activating ligands in real time during twitch contractions in live cardiac muscle

Journal of molecular and cellular cardiology, 2020-10, Vol.147, p.49-61

2020

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Sarcomere neutralization in inherited cardiomyopathy: small-molecule proof-of-concept to correct hyper-Ca2+-sensitive myofilaments

American journal of physiology. Heart and circulatory physiology, 2016-07, Vol.311 (1), p.H36-H43

2016

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Chemoproteomic Identification of Serine Hydrolase RBBP9 as a Valacyclovir-Activating Enzyme

Molecular pharmaceutics, 2020-05, Vol.17 (5), p.1706-1714

2020

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TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility

Biophysical journal, 2018-04, Vol.114 (7), p.1646-1656

2018

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Myofilament-based physiological regulatory compensation preserves diastolic function in failing hearts with severe Ca2+ handling deficits

JCI insight, 2024-02, Vol.9 (6)

2024

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Interaction of the Adipocyte Fatty Acid-binding Protein with the Hormone-sensitive Lipase: REGULATION BY FATTY ACIDS AND PHOSPHORYLATION

The Journal of biological chemistry, 2007-11, Vol.282 (44), p.32424-32432

2007

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Cytoplasmic nucleic acid-based XNAs directly enhance live cardiac cell function by a Ca2+ cycling-independent mechanism via the sarcomere

Journal of molecular and cellular cardiology, 2019-05, Vol.130, p.1-9

2019

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Cell Biology of Sarcomeric Protein Engineering: Disease Modeling and Therapeutic Potential

Anatomical record (Hoboken, N.J. : 2007), 2014-09, Vol.297 (9), p.1663-1669

2014

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Interaction of Adipocyte Fatty Acid-binding Protein (AFABP) and JAK2: AFABP/aP2 AS A REGULATOR OF JAK2 SIGNALING

The Journal of biological chemistry, 2009-05, Vol.284 (20), p.13473-13480

2009

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Abstract P1057: Implementing A Novel FRET-Based Myofilament Activation Biosensor To Interrogate Dynamic Cardiac Sarcomere Performance With Small Molecule And Genetic Manipulations During A Physiological Twitch

Circulation research, 2022-08, Vol.131 (Suppl_1)

2022

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Physical association between the adipocyte fatty acid-binding protein and hormone-sensitive lipase: a fluorescence resonance energy transfer analysis

The Journal of biological chemistry, 2004-12, Vol.279 (50), p.52399

2004

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Abstract 123: Study Of The Role Of Myosin-binding Protein C In The Structure-function Of Intact Cardiac Muscles Through The Use Of A Sarcomere Activation Biosensor

Circulation research, 2021-09, Vol.129 (Suppl_1)

2021

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Cardiac Sarcomere Signaling in Health and Disease

Inducing positive inotropy in human iPSC-derived cardiac muscle by gene editing-based activation of the cardiac α-myosin heavy chain

Sarcomere dynamics revealed by a myofilament integrated FRET-based biosensor in live skeletal muscle fibers

Fatty acid flux in adipocytes: The in's and out's of fat cell lipid trafficking

Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers

Molecular Determinants of Cardiac Myocyte Performance as Conferred by Isoform-Specific TnI Residues

Functional Equivalence of Retroviral MA Domains in Facilitating Psi RNA Binding Specificity by Gag

Pharmacokinetics of gemcitabine and its amino acid ester prodrug following intravenous and oral administrations in mice

Interrogation of skeletal muscle activation in an intact system via a myofilament incorporated FRET biosensor

Mechanisms of gemcitabine oral absorption as determined by in situ intestinal perfusions in mice

Advancing physiological maturation in human induced pluripotent stem cell‐derived cardiac muscle by gene editing an inducible adult troponin isoform switch

Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice

Physiologically-Based Pharmacokinetic Modeling to Predict Methylphenidate Exposure Affected by Interplay Among Carboxylesterase 1 Pharmacogenetics, Drug-Drug Interactions, and Sex

Sarcomere integrated biosensor detects myofilament-activating ligands in real time during twitch contractions in live cardiac muscle

Sarcomere neutralization in inherited cardiomyopathy: small-molecule proof-of-concept to correct hyper-Ca2+-sensitive myofilaments

Chemoproteomic Identification of Serine Hydrolase RBBP9 as a Valacyclovir-Activating Enzyme

TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility

Myofilament-based physiological regulatory compensation preserves diastolic function in failing hearts with severe Ca2+ handling deficits

Interaction of the Adipocyte Fatty Acid-binding Protein with the Hormone-sensitive Lipase: REGULATION BY FATTY ACIDS AND PHOSPHORYLATION

Cytoplasmic nucleic acid-based XNAs directly enhance live cardiac cell function by a Ca2+ cycling-independent mechanism via the sarcomere

Cell Biology of Sarcomeric Protein Engineering: Disease Modeling and Therapeutic Potential

Interaction of Adipocyte Fatty Acid-binding Protein (AFABP) and JAK2: AFABP/aP2 AS A REGULATOR OF JAK2 SIGNALING

Abstract P1057: Implementing A Novel FRET-Based Myofilament Activation Biosensor To Interrogate Dynamic Cardiac Sarcomere Performance With Small Molecule And Genetic Manipulations During A Physiological Twitch

Physical association between the adipocyte fatty acid-binding protein and hormone-sensitive lipase: a fluorescence resonance energy transfer analysis

Abstract 123: Study Of The Role Of Myosin-binding Protein C In The Structure-function Of Intact Cardiac Muscles Through The Use Of A Sarcomere Activation Biosensor

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