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Activating mutations in ALK provide a therapeutic target in neuroblastoma

Nature (London), 2008-10, Vol.455 (7215), p.975-978

2008

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Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease

PLoS pathogens, 2012-08, Vol.8 (8), p.e1002830-e1002830

2012

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The development and application of small molecule modulators of SF3b as therapeutic agents for cancer

Drug discovery today, 2013-01, Vol.18 (1-2), p.43-49

2013

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Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

Nature communications, 2017-01, Vol.8 (1), p.14060-14060, Article 14060

2017

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Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (13), p.3669-3674

2016

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The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Nature communications, 2017-12, Vol.8 (1), p.1910-7, Article 1910

2017

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Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping

RNA (Cambridge), 2018-08, Vol.24 (8), p.1056-1066

2018

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Optimization of Antitumor Modulators of Pre-mRNA Splicing

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10033-10044

2013

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An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

PloS one, 2020-05, Vol.15 (5), p.e0233672-e0233672

2020

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Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy

Expert review of anticancer therapy, 2009-03, Vol.9 (3), p.331-356

2009

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Pre-mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide–Herboxidiene Hybrid Analog and Related Derivatives

ACS chemical biology, 2014-03, Vol.9 (3), p.643-648

2014

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FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease-Associated Genetic Variant and Influences Monocyte Transendothelial Migration

Journal of the American Heart Association, 2020-02, Vol.9 (4), p.e014333-e014333

2020

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Inhibition or knockdown of ABC transporters enhances susceptibility of adult and juvenile schistosomes to Praziquantel

PLoS neglected tropical diseases, 2014-10, Vol.8 (10), p.e3265-e3265

2014

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Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency

mBio, 2018-11, Vol.9 (6)

2018

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Recent advances in computer-aided drug design as applied to anti-influenza drug discovery

Current topics in medicinal chemistry, 2014-10, Vol.14 (16), p.1875

2014

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Identification of Influenza Endonuclease Inhibitors Using a Novel Fluorescence Polarization Assay

ACS chemical biology, 2012-03, Vol.7 (3), p.526-534

2012

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Small Molecules That Reactivate p53 in Renal Cell Carcinoma Reveal a NF-κB-Dependent Mechanism of p53 Suppression in Tumors

Proceedings of the National Academy of Sciences - PNAS, 2005-11, Vol.102 (48), p.17448-17453

2005

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The spliceosome is a therapeutic vulnerability in MYC-driven cancer

Nature (London), 2015-09, Vol.525 (7569), p.384-388

2015

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Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention

Journal of the American College of Cardiology, 2018-10, Vol.72 (16), p.1883-1893

2018

Volltextzugriff (PDF)

Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors

Circulation. Genomic and precision medicine, 2019-01, Vol.12 (1), p.e002196

2019

Volltextzugriff (PDF)

Antitumor Compounds Based on a Natural Product Consensus Pharmacophore

Journal of medicinal chemistry, 2008-10, Vol.51 (19), p.6220-6224

2008

Volltextzugriff (PDF)

Improving the Efficiency of the Drug Development by Expanding the Scope of the Role of Medicinal Chemists in Drug Discovery

ACS medicinal chemistry letters, 2018-12, Vol.9 (12), p.1153-1155

Webb, Thomas R

2018

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Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism

Nucleic acids research, 2021-02, Vol.49 (3), p.1609

2021

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Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: Differential responses related to surface properties

Toxicology (Amsterdam), 2007-01, Vol.230 (1), p.90-104

2007

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Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6

Biomarker Insights, 2017, Vol.2017 (12), p.1177271917730557-1177271917730557

2017

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Activating mutations in ALK provide a therapeutic target in neuroblastoma

Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping

Optimization of Antitumor Modulators of Pre-mRNA Splicing

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy

Pre-mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide–Herboxidiene Hybrid Analog and Related Derivatives

FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease-Associated Genetic Variant and Influences Monocyte Transendothelial Migration

Inhibition or knockdown of ABC transporters enhances susceptibility of adult and juvenile schistosomes to Praziquantel

Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency

Recent advances in computer-aided drug design as applied to anti-influenza drug discovery

Identification of Influenza Endonuclease Inhibitors Using a Novel Fluorescence Polarization Assay

Small Molecules That Reactivate p53 in Renal Cell Carcinoma Reveal a NF-κB-Dependent Mechanism of p53 Suppression in Tumors

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention

Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors

Antitumor Compounds Based on a Natural Product Consensus Pharmacophore

Improving the Efficiency of the Drug Development by Expanding the Scope of the Role of Medicinal Chemists in Drug Discovery

Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism

Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: Differential responses related to surface properties

Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6

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