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Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy

Oncogene, 2016-01, Vol.35 (3), p.314-322

2016

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D91 NOVEL PATHWAYS IN PULMONARY FIBROSIS: Trpv4 Calcium Channel Deficiency Protects Against Pulmonary Fibrosis In Mice And Abrogates Myofibroblast Differentiation

American journal of respiratory and critical care medicine, 2014-01, Vol.189, p.1

2014

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Force meets chemistry: Analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching

Journal of cellular biochemistry, 2006-04, Vol.97 (6), p.1175-1183

2006

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Regulation of ADAM12 Cell-surface Expression by Protein Kinase C ϵ

The Journal of biological chemistry, 2004-12, Vol.279 (49), p.51601-51611

2004

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ADAM12/syndecan-4 signaling promotes beta(1) integrin-dependent cell spreading through protein kinase C alpha and RhoA

The Journal of biological chemistry, 2003-03, Vol.278 (11), p.9576

2003

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Hierarchy of ADAM12 binding to integrins in tumor cells

Experimental cell research, 2005-10, Vol.309 (2), p.438-450

2005

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Leukotriene D(4) triggers an association between gbetagamma subunits and phospholipase C-gamma1 in intestinal epithelial cells

The Journal of biological chemistry, 2000-03, Vol.275 (13), p.53

2000

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Leukotriene D(4) triggers an association between gbetagamma subunits and phospholipase C-gamma1 in intestinal epithelial cells

The Journal of biological chemistry, 2000-03, Vol.275 (13), p.9849-9853

2000

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The Epsilon Isoform of Protein Kinase C Is Involved in Regulation of the LTD4-Induced Calcium Signal in Human Intestinal Epithelial Cells

Experimental cell research, 2001-01, Vol.262 (2), p.95-103

2001

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Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane

Cell calcium (Edinburgh), 1998-07, Vol.24 (1), p.9-16

1998

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ADAM12/Syndecan-4 Signaling Promotes beta sub(1) Integrin-dependent Cell Spreading through Protein Kinase C alpha and RhoA

The Journal of biological chemistry, 2003-03, Vol.278 (11), p.9576-9584

2003

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Leukotriene D sub(4) induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane

Cell calcium (Edinburgh), 1998-07, Vol.24 (1), p.9-16

1998

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The epsilon isoform of protein kinase C is involved in regulation of the LTD(4)-induced calcium signal in human intestinal epithelial cells

Experimental cell research, 2001-01, Vol.262 (2), p.95

2001

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Leukotriene D 4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane

Cell calcium (Edinburgh), 1998-07, Vol.24 (1), p.9-16

1998

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ADAM 12-induced syndecan-beta 1 integrin mediated cell spreading is regulated by protein kinase C alpha, PI-3 kinase and Rac

Molecular biology of the cell, 2001, Vol.12 (Suppl. S), p.325

2001

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Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis

Cancer letters, 2019-02, Vol.442, p.15-20

2019

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Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4

The FASEB journal, 2019-01, Vol.33 (1), p.195-203

2019

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TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation

Scientific reports, 2015-09, Vol.5 (1), p.14257-14257, Article 14257

2015

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Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (32), p.11305-11310

2008

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Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis

Journal of cellular physiology, 2021-05, Vol.236 (5), p.3770-3779

2021

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TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway

Oncotarget, 2016-05, Vol.7 (18), p.25849-25861

2016

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4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling

Free radical biology & medicine, 2016-12, Vol.101, p.10-19

2016

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Abstract 24061: Targeting Trpv4 Channels Protects Heart From Pathological Remodeling Following Myocardial Infarction

Circulation (New York, N.Y.), 2017-11, Vol.136 (suppl_1)

2017

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A novel cross talk between mechanosensitive ion channel TRPV4 and VEGFR2 in human endothelial cells

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Abstract 364: TRPV4 Channel Acts as a Negative Regulator of Angiogenesis by Modulation of Rho/Rho Kinase Pathway

Arteriosclerosis, thrombosis, and vascular biology, 2016-05, Vol.36 (suppl_1)

2016

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Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy

D91 NOVEL PATHWAYS IN PULMONARY FIBROSIS: Trpv4 Calcium Channel Deficiency Protects Against Pulmonary Fibrosis In Mice And Abrogates Myofibroblast Differentiation

Force meets chemistry: Analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching

Regulation of ADAM12 Cell-surface Expression by Protein Kinase C ϵ

ADAM12/syndecan-4 signaling promotes beta(1) integrin-dependent cell spreading through protein kinase C alpha and RhoA

Hierarchy of ADAM12 binding to integrins in tumor cells

Leukotriene D(4) triggers an association between gbetagamma subunits and phospholipase C-gamma1 in intestinal epithelial cells

Leukotriene D(4) triggers an association between gbetagamma subunits and phospholipase C-gamma1 in intestinal epithelial cells

The Epsilon Isoform of Protein Kinase C Is Involved in Regulation of the LTD4-Induced Calcium Signal in Human Intestinal Epithelial Cells

Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane

ADAM12/Syndecan-4 Signaling Promotes beta sub(1) Integrin-dependent Cell Spreading through Protein Kinase C alpha and RhoA

Leukotriene D sub(4) induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane

The epsilon isoform of protein kinase C is involved in regulation of the LTD(4)-induced calcium signal in human intestinal epithelial cells

Leukotriene D 4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane

ADAM 12-induced syndecan-beta 1 integrin mediated cell spreading is regulated by protein kinase C alpha, PI-3 kinase and Rac

Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis

Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4

TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation

Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro

Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis

TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway

4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling

Abstract 24061: Targeting Trpv4 Channels Protects Heart From Pathological Remodeling Following Myocardial Infarction

A novel cross talk between mechanosensitive ion channel TRPV4 and VEGFR2 in human endothelial cells

Abstract 364: TRPV4 Channel Acts as a Negative Regulator of Angiogenesis by Modulation of Rho/Rho Kinase Pathway

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