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Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2940-2955

2022

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Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo

Nature communications, 2023-06, Vol.14 (1), p.3737-3737, Article 3737

2023

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Potential Mechanisms of Estrogen Quinone Carcinogenesis

Chemical research in toxicology, 2008-01, Vol.21 (1), p.93-101

2008

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Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons

JAMA psychiatry (Chicago, Ill.), 2020-11, Vol.77 (11), p.1172

2020

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Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.7186-7210

2020

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Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1325-1342

2017

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MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3

Oncogene, 2021-10, Vol.40 (43), p.6153-6165

2021

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Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11301-11323

2019

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Cysteine proteases as therapeutic targets:does selectivity matter? A systematic review of calpain and cathepsin inhibitors

Acta pharmaceutica Sinica. B, 2015-11, Vol.5 (6), p.506-519

2015

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TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer

Oncogene, 2023-03, Vol.42 (14), p.1132-1143

2023

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Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry

ACS chemical biology, 2018-08, Vol.13 (8), p.2190-2202

2018

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Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein

The Journal of biological chemistry, 2016-02, Vol.291 (7), p.3639-3647

2016

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Discovery and Structural Optimization of 4‑(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.7211-7225

2020

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Optimization of 4‑Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir

Journal of medicinal chemistry, 2020-03, Vol.63 (6), p.3120-3130

2020

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Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation

Neurotherapeutics, 2023-07, Vol.20 (4), p.1120-1137

2023

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Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.11085-11099

2020

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Time-Gated Luminescence Detection of Enzymatically Produced Hydrogen Sulfide: Design, Synthesis, and Application of a Lanthanide-Based Probe

Inorganic chemistry, 2018-01, Vol.57 (2), p.681-688

2018

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G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer

Breast cancer research and treatment, 2020-04, Vol.180 (3), p.635-646

2020

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Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET)-First Bromodomain (BD1) Inhibitors

Journal of medicinal chemistry, 2024-02, Vol.67 (4), p.2712-2731

2024

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Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry

PLoS pathogens, 2021-02, Vol.17 (2), p.e1009312-e1009312

2021

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Furoxans (1,2,5-Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents

Journal of medicinal chemistry, 2012-04, Vol.55 (7), p.3076-3087

2012

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Targeting NO/cGMP Signaling in the CNS for Neurodegeneration and Alzheimer's Disease

Current medicinal chemistry, 2016-01, Vol.23 (24), p.2770-2788

2016

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Iodocyclization of S–(homo)propargyl dithiocarbamates: Regiospecific synthesis of 2-imino(iminium)-1, 3-dithiolanes/dithianes/dithiepanes

Tetrahedron letters, 2023-09, Vol.128, p.154702, Article 154702

2023

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Remembering your A, B, C's: Alzheimer's disease and ABCA1

Acta pharmaceutica Sinica. B, 2022-03, Vol.12 (3), p.995-1018

2022

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The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development

PLoS neglected tropical diseases, 2015-12, Vol.9 (12), p.e0004279-e0004279

2015

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Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity

Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo

Potential Mechanisms of Estrogen Quinone Carcinogenesis

Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons

Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib

Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer

MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3

Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer

Cysteine proteases as therapeutic targets:does selectivity matter? A systematic review of calpain and cathepsin inhibitors

TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer

Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry

Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein

Discovery and Structural Optimization of 4‑(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections

Optimization of 4‑Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir

Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation

Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors

Time-Gated Luminescence Detection of Enzymatically Produced Hydrogen Sulfide: Design, Synthesis, and Application of a Lanthanide-Based Probe

G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer

Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET)-First Bromodomain (BD1) Inhibitors

Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry

Furoxans (1,2,5-Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents

Targeting NO/cGMP Signaling in the CNS for Neurodegeneration and Alzheimer's Disease

Iodocyclization of S–(homo)propargyl dithiocarbamates: Regiospecific synthesis of 2-imino(iminium)-1, 3-dithiolanes/dithianes/dithiepanes

Remembering your A, B, C's: Alzheimer's disease and ABCA1

The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development

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