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Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.504-513

2018

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Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Journal of medicinal chemistry, 2019-01, Vol.62 (2), p.699-726

2019

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Structural basis of PROTAC cooperative recognition for selective protein degradation

Nature chemical biology, 2017-05, Vol.13 (5), p.514

2017

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Structure‐Based Design of a Macrocyclic PROTAC

Angewandte Chemie (International ed.), 2020-01, Vol.59 (4), p.1727-1734

International ed. in English, 2020

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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Nature communications, 2017-10, Vol.8 (1), p.830-14, Article 830

2017

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Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

Journal of medicinal chemistry, 2021-10, Vol.64 (20), p.15477-15502

2021

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Phase-separated droplets swim to their dissolution

Nature communications, 2024-05, Vol.15 (1), p.3919-3919, Article 3919

2024

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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System

Cell chemical biology, 2020-09, Vol.27 (9), p.1164-1180.e5

2020

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Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

Nature communications, 2023-10, Vol.14 (1), p.6345-6345, Article 6345

2023

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Automated Detection of Spinal Lesions From CT Scans via Deep Transfer Learning

IEEE access, 2024, Vol.12, p.65310-65322

2024

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New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease

Haematologica (Roma), 2019-06, Vol.104 (6), p.e256

2019

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PET Tracers To Study Clinically Relevant Hepatic Transporters

Molecular pharmaceutics, 2015-07, Vol.12 (7), p.2203-2216

2015

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Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

Nature communications, 2022-04, Vol.13 (1), p.2073-2073, Article 2073

2022

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Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters

Bioorganic & medicinal chemistry, 2017-02, Vol.25 (3), p.963-976

2017

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Estimating Satellite Navigation Broadcast Ephemeris via Inter-Satellite and Ground-to-Satellite Ranging

Engineering proceedings, 2023-10, Vol.54 (1), p.15

2023

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Generalized Assignment for Multi-Robot Systems via Distributed Branch-And-Price

IEEE transactions on robotics, 2022-06, Vol.38 (3), p.1990-2001

2022

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Multi-Robot Pickup and Delivery via Distributed Resource Allocation

IEEE transactions on robotics, 2023-04, Vol.39 (2), p.1106-1118

2023

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Distributed Mixed-Integer Linear Programming via Cut Generation and Constraint Exchange

IEEE transactions on automatic control, 2020-04, Vol.65 (4), p.1456-1467

2020

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The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type

Exploration of targeted anti-tumor therapy, 2021, Vol.2 (6), p.586-601

2021

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Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

Bioorganic & medicinal chemistry, 2019-06, Vol.27 (12), p.2466-2479

2019

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The rise and rise of protein degradation: Opportunities and challenges ahead

Drug discovery today, 2021-12, Vol.26 (12), p.2889-2897

2021

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Q-Learning-based model predictive variable impedance control for physical human-robot collaboration

Artificial intelligence, 2022-11, Vol.312, p.103771, Article 103771

2022

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ChoiRbot: A ROS 2 Toolbox for Cooperative Robotics

IEEE robotics and automation letters, 2021-04, Vol.6 (2), p.2714-2720

2021

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Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

ACS chemical biology, 2019-09, Vol.14 (9), p.2024-2034

2019

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Stereoselective synthesis of allele-specific BET inhibitors

Organic & biomolecular chemistry, 2020-10, Vol.18 (38), p.7533-7539

2020

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Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Structural basis of PROTAC cooperative recognition for selective protein degradation

Structure‐Based Design of a Macrocyclic PROTAC

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

Phase-separated droplets swim to their dissolution

Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

Automated Detection of Spinal Lesions From CT Scans via Deep Transfer Learning

New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease

PET Tracers To Study Clinically Relevant Hepatic Transporters

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters

Estimating Satellite Navigation Broadcast Ephemeris via Inter-Satellite and Ground-to-Satellite Ranging

Generalized Assignment for Multi-Robot Systems via Distributed Branch-And-Price

Multi-Robot Pickup and Delivery via Distributed Resource Allocation

Distributed Mixed-Integer Linear Programming via Cut Generation and Constraint Exchange

The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

The rise and rise of protein degradation: Opportunities and challenges ahead

Q-Learning-based model predictive variable impedance control for physical human-robot collaboration

ChoiRbot: A ROS 2 Toolbox for Cooperative Robotics

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

Stereoselective synthesis of allele-specific BET inhibitors

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