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Use of human lymphocyte G0 PCCs to detect intra- and inter-chromosomal aberrations for early radiation biodosimetry and retrospective assessment of radiation-induced effects

PloS one, 2019-05, Vol.14 (5), p.e0216081

2019

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Interphase Cytogenetic Analysis of Micronucleated and Multinucleated Cells Supports the Premature Chromosome Condensation Hypothesis as the Mechanistic Origin of Chromothripsis

Cancers, 2019-08, Vol.11 (8), p.1123

2019

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Non-targeted radiation effects in vivo : A critical glance of the future in radiobiology

Cancer letters, 2015-01, Vol.356 (1), p.34-42

2015

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Dose assessment intercomparisons within the RENEB network using G0-lymphocyte prematurely condensed chromosomes (PCC assay)

International journal of radiation biology, 2017-01, Vol.93 (1), p.48-57

2017

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Molecular Biomarkers for Predicting Cancer Patient Radiosensitivity and Radiotoxicity in Clinical Practice

Applied sciences, 2023-11, Vol.13 (23), p.12564

2023

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G2/M Checkpoint Abrogation With Selective Inhibitors Results in Increased Chromatid Breaks and Radiosensitization of 82-6 hTERT and RPE Human Cells

Frontiers in public health, 2021-05, Vol.9, p.675095-675095

2021

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Interphase Cytogenetic Analysis of G0 Lymphocytes Exposed to α-Particles, C-Ions, and Protons Reveals their Enhanced Effectiveness for Localized Chromosome Shattering—A Critical Risk for Chromothripsis

Cancers, 2020-08, Vol.12 (9), p.2336

2020

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Development of an automatable micro-PCC biodosimetry assay for rapid individualized risk assessment in large-scale radiological emergencies

Mutation research. Genetic toxicology and environmental mutagenesis, 2018-12, Vol.836 (Pt A), p.65-71

2018

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The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology

Frontiers in public health, 2021-07, Vol.9, p.701878-701878

2021

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Checkpoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells

Cancer research (Chicago, Ill.), 2005-12, Vol.65 (24), p.11292-11296

2005

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BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions

Chemico-biological interactions, 2010-11, Vol.188 (2), p.350-358

2010

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Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET)

Free radical research, 2016-11, Vol.50 (sup1), p.S64-S78

2016

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Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis

Mutation research. Genetic toxicology and environmental mutagenesis, 2015-11, Vol.793, p.185-198

2015

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Construction and evaluation of an α-particle-irradiation exposure apparatus

International journal of radiation biology, 2021, Vol.97 (10), p.1404-1416

2021

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A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation

International journal of radiation oncology, biology, physics, 2019-04, Vol.103 (5), p.1184-1193

2019

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Triage biodosimetry using centromeric/telomeric PNA probes and Giemsa staining to score dicentrics or excess fragments in non-stimulated lymphocyte prematurely condensed chromosomes

Mutation research. Genetic toxicology and environmental mutagenesis, 2015-11, Vol.793, p.107-114

2015

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A standardized G2-assay for the prediction of individual radiosensitivity

Radiotherapy and oncology, 2011-10, Vol.101 (1), p.28-34

2011

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Low concentrations of caffeine induce asymmetric cell division as observed in vitro by means of the CBMN-assay and iFISH

Mutation research. Genetic toxicology and environmental mutagenesis, 2015-11, Vol.793, p.71-78

2015

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Functional cell-cycle chromatin conformation changes in the presence of DNA damage result into chromatid breaks: A new insight in the formation of radiation-induced chromosomal aberrations based on the direct observation of interphase chromatin

Mutation research, 2010-08, Vol.701 (1), p.27-37

2010

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Biodosimetry for High-Dose Exposures Based on Dicentric Analysis in Lymphocytes Released from the G2-Block by Caffeine

Radiation protection dosimetry, 2016-12, Vol.172 (1-3), p.230-237

2016

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Dose assessment intercomparisons within the RENEB network using G 0 -lymphocyte prematurely condensed chromosomes (PCC assay)

International journal of radiation biology, 2017-01, Vol.93 (1), p.48-57

2017

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Mitochondria malfunctions as mediators of stem-cells’ related carcinogenesis: A hypothesis that supports the highly conserved profile of carcinogenesis

Medical hypotheses, 2013-01, Vol.80 (1), p.70-74

2013

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G2-checkpoint abrogation in irradiated lymphocytes: A new cytogenetic approach to assess individual radiosensitivity and predisposition to cancer

International journal of oncology, 2009-11, Vol.35 (5), p.1223-1230

2009

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The use of premature chromosome condensation to study in interphase cells the influence of environmental factors on human genetic material

TheScientificWorld, 2006-09, Vol.6, p.1174-1190

2006

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The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease

Free radical biology & medicine, 2011-08, Vol.51 (3), p.713-718

2011

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Use of human lymphocyte G0 PCCs to detect intra- and inter-chromosomal aberrations for early radiation biodosimetry and retrospective assessment of radiation-induced effects

Interphase Cytogenetic Analysis of Micronucleated and Multinucleated Cells Supports the Premature Chromosome Condensation Hypothesis as the Mechanistic Origin of Chromothripsis

Non-targeted radiation effects in vivo : A critical glance of the future in radiobiology

Dose assessment intercomparisons within the RENEB network using G0-lymphocyte prematurely condensed chromosomes (PCC assay)

Molecular Biomarkers for Predicting Cancer Patient Radiosensitivity and Radiotoxicity in Clinical Practice

G2/M Checkpoint Abrogation With Selective Inhibitors Results in Increased Chromatid Breaks and Radiosensitization of 82-6 hTERT and RPE Human Cells

Interphase Cytogenetic Analysis of G0 Lymphocytes Exposed to α-Particles, C-Ions, and Protons Reveals their Enhanced Effectiveness for Localized Chromosome Shattering—A Critical Risk for Chromothripsis

Development of an automatable micro-PCC biodosimetry assay for rapid individualized risk assessment in large-scale radiological emergencies

The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology

Checkpoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells

BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions

Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET)

Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis

Construction and evaluation of an α-particle-irradiation exposure apparatus

A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation

Triage biodosimetry using centromeric/telomeric PNA probes and Giemsa staining to score dicentrics or excess fragments in non-stimulated lymphocyte prematurely condensed chromosomes

A standardized G2-assay for the prediction of individual radiosensitivity

Low concentrations of caffeine induce asymmetric cell division as observed in vitro by means of the CBMN-assay and iFISH

Functional cell-cycle chromatin conformation changes in the presence of DNA damage result into chromatid breaks: A new insight in the formation of radiation-induced chromosomal aberrations based on the direct observation of interphase chromatin

Biodosimetry for High-Dose Exposures Based on Dicentric Analysis in Lymphocytes Released from the G2-Block by Caffeine

Dose assessment intercomparisons within the RENEB network using G 0 -lymphocyte prematurely condensed chromosomes (PCC assay)

Mitochondria malfunctions as mediators of stem-cells’ related carcinogenesis: A hypothesis that supports the highly conserved profile of carcinogenesis

G2-checkpoint abrogation in irradiated lymphocytes: A new cytogenetic approach to assess individual radiosensitivity and predisposition to cancer

The use of premature chromosome condensation to study in interphase cells the influence of environmental factors on human genetic material

The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease

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