UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 97

Sortiert nach

Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Required for the Development of Ischemic Neuronal Death

The Journal of neuroscience, 2005-03, Vol.25 (10), p.2647-2657

2005

Volltextzugriff (PDF)

Challenges in developing Geroscience trials

Nature communications, 2023-08, Vol.14 (1), p.5038-5038, Article 5038

2023

Volltextzugriff (PDF)

Strategies for delivering therapeutics across the blood-brain barrier

Nature reviews. Drug discovery, 2021-05, Vol.20 (5), p.362-383

2021

Volltextzugriff (PDF)

Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems

Drug discovery today, 2018-07, Vol.23 (7), p.1357-1372

2018

Volltextzugriff (PDF)

A call for better understanding of target engagement in Tau antibody development

Drug discovery today, 2022-11, Vol.27 (11), p.103338-103338, Article 103338

2022

Volltextzugriff (PDF)

Target deconvolution strategies in drug discovery

Nature reviews. Drug discovery, 2007-11, Vol.6 (11), p.891-903

2007

Volltextzugriff (PDF)

Combining experimental strategies for successful target deconvolution

Drug discovery today, 2020-11, Vol.25 (11), p.1998-2005

2020

Volltextzugriff (PDF)

Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

Pharmaceutical research, 2022-07, Vol.39 (7), p.1321-1341

2022

Volltextzugriff (PDF)

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

Journal of neurochemistry, 2010-03, Vol.112 (6), p.1539-1551

2010

Volltextzugriff (PDF)

Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain

The Journal of neuroscience, 2004-06, Vol.24 (26), p.6021-6027

2004

Volltextzugriff (PDF)

In silico research in drug discovery

Trends in pharmacological sciences (Regular ed.), 2001-01, Vol.22 (1), p.23-26

2001

Volltextzugriff (PDF)

Label-free detection of small-molecule binding to a GPCR in the membrane environment

Biochimica et biophysica acta, 2015-08, Vol.1854 (8), p.979-986

2015

Volltextzugriff (PDF)

Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src–Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity

Circulation research, 2010-06, Vol.106 (12), p.1839-1848

2010

Volltextzugriff (PDF)

Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs

Neuroscience bulletin, 2019-12, Vol.35 (6), p.996-1010

2019

Volltextzugriff (PDF)

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

Stem cell reports, 2018-10, Vol.11 (4), p.897-911

2018

Volltextzugriff (PDF)

Brain delivery research in public-private partnerships: The IMI-JU COMPACT consortium as an example

Neuropharmacology, 2017-07, Vol.120, p.8-10

2017

Volltextzugriff (PDF)

Generating Human iPSC-Derived Astrocytes with Chemically Defined Medium for In Vitro Disease Modeling

Methods in molecular biology (Clifton, N.J.), 2019, Vol.1994, p.31

2019

Volltextzugriff (PDF)

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1

Neurobiology of disease, 2006-11, Vol.24 (2), p.254-265

2006

Volltextzugriff (PDF)

Targeting mutant huntingtin for the development of disease-modifying therapy

Drug discovery today, 2012-11, Vol.17 (21-22), p.1217-1223

2012

Volltextzugriff (PDF)

Development and validation of a fluorescence-based HTS assay for the identification of P/Q-type calcium channel blockers

Combinatorial chemistry & high throughput screening, 2012-06, Vol.15 (5), p.372

2012

Volltextzugriff (PDF)

Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades

Neuropharmacology, 2012-06, Vol.62 (7), p.2183-2190

2012

Volltextzugriff (PDF)

Screening technologies for ion channel drug discovery

Future medicinal chemistry, 2010-05, Vol.2 (5), p.715-730

2010

Volltextzugriff (PDF)

The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer's disease?

Trends in pharmacological sciences (Regular ed.), 2003-05, Vol.24 (5), p.233-238

2003

Volltextzugriff (PDF)

Small molecule drug discovery for Huntington's Disease

Drug discovery today, 2009-05, Vol.14 (9), p.453-464

2009

Volltextzugriff (PDF)

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

iScience, 2022-08, Vol.25 (8), p.104787-104787, Article 104787

2022

Volltextzugriff (PDF)

1 – 25 von 97

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(91)
Mit Volltextzugriff
(84)

Publikationsform

Artikel
(94)
Buchkapitel
(3)

Sprache

Englisch
(97)
Japanisch
(16)

Erscheinungsjahr

n.n

Thema

Science & Technology
(63)
Life Sciences & Biomedicine
(59)
Animals
(42)
Humans
(39)
Pharmacology & Pharmacy
(28)
Rats
(24)
Biochemistry & Molecular Biology
(20)
Biological And Medical Sciences
(20)
Chemistry
(14)
Neurosciences
(13)
Neurosciences & Neurology
(13)
Physical Sciences
(11)
Cell Line
(10)
Fundamental And Applied Biological Sciences. Psychology
(10)
Medical Sciences
(10)
Biochemical Research Methods
(9)
Neurology
(9)
Neurons - Metabolism
(9)
Alpha7 Nicotinic Acetylcholine Receptor
(8)
Cell Biology
(8)

15 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Required for the Development of Ischemic Neuronal Death

Challenges in developing Geroscience trials

Strategies for delivering therapeutics across the blood-brain barrier

Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems

A call for better understanding of target engagement in Tau antibody development

Target deconvolution strategies in drug discovery

Combining experimental strategies for successful target deconvolution

Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain

In silico research in drug discovery

Label-free detection of small-molecule binding to a GPCR in the membrane environment

Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src–Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity

Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

Brain delivery research in public-private partnerships: The IMI-JU COMPACT consortium as an example

Generating Human iPSC-Derived Astrocytes with Chemically Defined Medium for In Vitro Disease Modeling

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1

Targeting mutant huntingtin for the development of disease-modifying therapy

Development and validation of a fluorescence-based HTS assay for the identification of P/Q-type calcium channel blockers

Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades

Screening technologies for ion channel drug discovery

The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer's disease?

Small molecule drug discovery for Huntington's Disease

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

Suchergebnisse filtern