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Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

Nature communications, 2020-01, Vol.11 (1), p.609-16, Article 609

2020

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Disulfiram Ophthalmic Solution Inhibited Macrophage Infiltration by Suppressing Macrophage Pseudopodia Formation in a Rat Corneal Alkali Burn Model

International journal of molecular sciences, 2023-01, Vol.24 (1), p.735

2023

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Inhibition of the chemokine signal regulator FROUNT by disulfiram ameliorates crescentic glomerulonephritis

Kidney international, 2022-12, Vol.102 (6), p.1276-1290

2022

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Disulfiram, an Anti-alcoholic Drug, Targets Macrophages and Attenuates Acute Rejection in Rat Lung Allografts

Transplant international, 2024-04, Vol.37, p.12556-12556

2024

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Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4

The Journal of biological chemistry, 2009-12, Vol.284 (50), p.35240-35250

2009

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Rational Design of Monodispersed Mutants of Proteins by Identifying Aggregation Contact Sites Using Solubilizing Agents

Biochemistry (Easton), 2020-10, Vol.59 (39), p.3639-3649

2020

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Choroidal Neovascularization Is Inhibited in Splenic-Denervated or Splenectomized Mice with a Concomitant Decrease in Intraocular Macrophage

PloS one, 2016-08, Vol.11 (8), p.e0160985-e0160985

2016

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Radiosynthesis of [thiocarbonyl-11C]disulfiram and its first PET study in mice

Bioorganic & medicinal chemistry letters, 2020-03, Vol.30 (6), p.126998, Article 126998

2020

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Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice

Frontiers in pharmacology, 2022-03, Vol.13, p.826783-826783

2022

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Robust Antitumor Effects of Combined Anti-CD4-Depleting Antibody and Anti-PD-1/PD-L1 Immune Checkpoint Antibody Treatment in Mice

Cancer immunology research, 2015-06, Vol.3 (6), p.631-640

2015

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Peyer's patch is the essential site in initiating murine acute and lethal graft- versus -host reaction

Nature immunology, 2003-02, Vol.4 (2), p.154-160

2003

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Disulfiram treatment suppresses antibody-producing reactions by inhibiting macrophage activation and B cell pyrimidine metabolism

Communications biology, 2024-04, Vol.7 (1), p.488-488, Article 488

2024

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Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein

Genes to cells : devoted to molecular & cellular mechanisms, 2018-02, Vol.23 (2), p.70-79

2018

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Identification and Preparation of a Novel Chemokine Receptor-Binding Domain in the Cytoplasmic Regulator FROUNT

Molecular biotechnology, 2017-05, Vol.59 (4-5), p.141-150

2017

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Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions

The Journal of clinical investigation, 1999-10, Vol.104 (8), p.1097-1105

1999

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FROUNT Is a Common Regulator of CCR2 and CCR5 Signaling to Control Directional Migration

The Journal of immunology (1950), 2009-11, Vol.183 (10), p.6387-6394

2009

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Identification of a binding element for the cytoplasmic regulator FROUNT in the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR5

Biochemical journal, 2014-01, Vol.457 (2), p.313-322

2014

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A conceptual molecular network for chemotactic behaviors characterized by feedback of molecules cycling between the membrane and the cytosol

Science signaling, 2010-12, Vol.3 (152), p.ra89

2010

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Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis

Nature Immunology, 2005-08, Vol.6 (8), p.827-835

2005

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ADAMTS-1 Is an Active Metalloproteinase Associated with the Extracellular Matrix

The Journal of biological chemistry, 1999-06, Vol.274 (26), p.18821-18826

1999

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1H, 13C and 15N resonance assignments for a chemokine receptor-binding domain of FROUNT, a cytoplasmic regulator of chemotaxis

Biomolecular NMR assignments, 2018-10, Vol.12 (2), p.259-262

2018

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Expression and purification of human FROUNT, a common cytosolic regulator of CCR2 and CCR5

Protein expression and purification, 2011-05, Vol.77 (1), p.86-91

2011

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Chemokines in inflammatory and immune diseases

Inflammation and Regeneration, 2011, Vol.31(1), pp.11-22

2011

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NMR Analyses of the Interaction between CCR5 and Its Ligand Using Functional Reconstitution of CCR5 in Lipid Bilayers

Journal of the American Chemical Society, 2010-05, Vol.132 (19), p.6768-6777

2010

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Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis

Arthritis research & therapy, 2011-01, Vol.13 (5), p.R158-R158

2011

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Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

Disulfiram Ophthalmic Solution Inhibited Macrophage Infiltration by Suppressing Macrophage Pseudopodia Formation in a Rat Corneal Alkali Burn Model

Inhibition of the chemokine signal regulator FROUNT by disulfiram ameliorates crescentic glomerulonephritis

Disulfiram, an Anti-alcoholic Drug, Targets Macrophages and Attenuates Acute Rejection in Rat Lung Allografts

Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4

Rational Design of Monodispersed Mutants of Proteins by Identifying Aggregation Contact Sites Using Solubilizing Agents

Choroidal Neovascularization Is Inhibited in Splenic-Denervated or Splenectomized Mice with a Concomitant Decrease in Intraocular Macrophage

Radiosynthesis of [thiocarbonyl-11C]disulfiram and its first PET study in mice

Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice

Robust Antitumor Effects of Combined Anti-CD4-Depleting Antibody and Anti-PD-1/PD-L1 Immune Checkpoint Antibody Treatment in Mice

Peyer's patch is the essential site in initiating murine acute and lethal graft- versus -host reaction

Disulfiram treatment suppresses antibody-producing reactions by inhibiting macrophage activation and B cell pyrimidine metabolism

Efficient identification of compounds suppressing protein precipitation via solvent screening using serial deletion mutants of the target protein

Identification and Preparation of a Novel Chemokine Receptor-Binding Domain in the Cytoplasmic Regulator FROUNT

Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions

FROUNT Is a Common Regulator of CCR2 and CCR5 Signaling to Control Directional Migration

Identification of a binding element for the cytoplasmic regulator FROUNT in the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR5

A conceptual molecular network for chemotactic behaviors characterized by feedback of molecules cycling between the membrane and the cytosol

Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis

ADAMTS-1 Is an Active Metalloproteinase Associated with the Extracellular Matrix

1H, 13C and 15N resonance assignments for a chemokine receptor-binding domain of FROUNT, a cytoplasmic regulator of chemotaxis

Expression and purification of human FROUNT, a common cytosolic regulator of CCR2 and CCR5

Chemokines in inflammatory and immune diseases

NMR Analyses of the Interaction between CCR5 and Its Ligand Using Functional Reconstitution of CCR5 in Lipid Bilayers

Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis

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