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A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation

Clinical & experimental metastasis, 2004-01, Vol.21 (2), p.159-166

2004

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Inhibition of Tumor Invasion by Genomic Down-regulation of Matriptase through Suppression of Activation of Receptor-bound Pro-urokinase

The Journal of biological chemistry, 2004-04, Vol.279 (15), p.14899-14908

2004

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A Kunitz-type Protease Inhibitor, Bikunin, Inhibits Ovarian Cancer Cell Invasion by Blocking the Calcium-dependent Transforming Growth Factor-β1 Signaling Cascade

The Journal of biological chemistry, 2003-03, Vol.278 (10), p.7790-7799

2003

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Suppression of Urokinase Expression and Invasiveness by Urinary Trypsin Inhibitor Is Mediated through Inhibition of Protein Kinase C- and MEK/ERK/c-Jun-dependent Signaling Pathways

The Journal of biological chemistry, 2001-01, Vol.276 (3), p.2015-2022

2001

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Plasma Bikunin As a Favorable Prognostic Factor in Ovarian Cancer

Journal of clinical oncology, 2005-03, Vol.23 (7), p.1463-1472

2005

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Prenatal and peripartum management of congenital afibrinogenaemia

British journal of haematology, 2000-05, Vol.109 (2), p.364-366

2000

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Hyaluronic acid-specific regulation of cytokines by human uterine fibroblasts

American Journal of Physiology: Cell Physiology, 1997-10, Vol.273 (4), p.C1151-C1159

1997

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Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin

International journal of cancer, 2003-04, Vol.104 (3), p.289-302

2003

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CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase‐type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells

International journal of cancer, 2002-12, Vol.102 (4), p.379-389

2002

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Genetic downregulation of pregnancy‐associated plasma protein‐A (PAPP‐A) by bikunin reduces IGF‐I‐dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis

International journal of cancer, 2004-04, Vol.109 (3), p.336-347

2004

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Bikunin Target Genes in Ovarian Cancer Cells Identified by Microarray Analysis

The Journal of biological chemistry, 2003-04, Vol.278 (17), p.14640-14646

2003

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Combined passive and active immunoprophylaxis for preventing perinatal transmission of the hepatitis B virus carrier state in Shizuoka, Japan during 1980-1994

Journal of gastroenterology and hepatology, 2003-08, Vol.18 (8), p.943-949

2003

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Genetic Down-regulation of Phosphoinositide 3-Kinase by Bikunin Correlates with Suppression of Invasion and Metastasis in Human Ovarian Cancer HRA Cells

The Journal of biological chemistry, 2004-02, Vol.279 (8), p.6371-6379

2004

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Reproductive failure in mice lacking inter-alpha-trypsin inhibitor (ITI) – ITI target genes in mouse ovary identified by microarray analysis

Journal of endocrinology, 2004-10, Vol.183 (1), p.29-38

2004

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Follicle-Stimulating Hormone and Insulin-Like Growth Factor I Synergistically Induce Up-Regulation of Cartilage Link Protein (Crtl1) via Activation of Phosphatidylinositol-Dependent Kinase/Akt in Rat Granulosa Cells

Endocrinology (Philadelphia), 2003-03, Vol.144 (3), p.793-801

2003

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Bikunin down-regulates heterodimerization between CD44 and growth factor receptors and subsequently suppresses agonist-mediated signaling

Journal of cellular biochemistry, 2005-04, Vol.94 (5), p.995-1009

2005

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Suppression of Urokinase Expression and Invasion by a Soybean Kunitz Trypsin Inhibitor Are Mediated through Inhibition of Src-dependent Signaling Pathways

The Journal of biological chemistry, 2005-09, Vol.280 (36), p.31428-31437

2005

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Bikunin Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Induction in Macrophages

Clinical and Diagnostic Laboratory Immunology, 2004-11, Vol.11 (6), p.1140-1147

2004

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The Idea of the Maternal Protection Act and Its Application: From the standpoint of Japan Association of Obstetricians & Gynecologists

Japan Medical Association journal, 2012-05, Vol.55 (3), p.208-212

Terao, Toshihiko

2012

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Reduced bikunin gene expression as a factor of poor prognosis in ovarian carcinoma

Cancer, 2003-07, Vol.98 (2), p.424-430

2003

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Kunitz-type Protease Inhibitor Bikunin Disrupts Phorbol Ester-induced Oligomerization of CD44 Variant Isoforms Containing Epitope v9 and Subsequently Suppresses Expression of Urokinase-type Plasminogen Activator in Human Chondrosarcoma Cells

The Journal of biological chemistry, 2002-03, Vol.277 (10), p.8022-8032

2002

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Identity of Urinary Trypsin Inhibitor-binding Protein to Link Protein

The Journal of biological chemistry, 2000-07, Vol.275 (28), p.21185-21191

2000

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Cold-induced stress stimulates the sympathetic nervous system, causing hypertension and proteinuria in rats

Journal of hypertension, 1997-04, Vol.15 (4), p.383-389

1997

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Ovarian endometrioma—Risks factors of ovarian cancer development

European journal of obstetrics & gynecology and reproductive biology, 2008-06, Vol.138 (2), p.187-193

2008

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Clinical Significance of Combined Use of Macrophage Colony-Stimulating Factor and Squamous Cell Carcinoma Antigen as a Selective Diagnostic Marker for Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary

Gynecologic oncology, 2000-06, Vol.77 (3), p.405-409

2000

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A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation

Inhibition of Tumor Invasion by Genomic Down-regulation of Matriptase through Suppression of Activation of Receptor-bound Pro-urokinase

A Kunitz-type Protease Inhibitor, Bikunin, Inhibits Ovarian Cancer Cell Invasion by Blocking the Calcium-dependent Transforming Growth Factor-β1 Signaling Cascade

Suppression of Urokinase Expression and Invasiveness by Urinary Trypsin Inhibitor Is Mediated through Inhibition of Protein Kinase C- and MEK/ERK/c-Jun-dependent Signaling Pathways

Plasma Bikunin As a Favorable Prognostic Factor in Ovarian Cancer

Prenatal and peripartum management of congenital afibrinogenaemia

Hyaluronic acid-specific regulation of cytokines by human uterine fibroblasts

Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin

CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase‐type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells

Genetic downregulation of pregnancy‐associated plasma protein‐A (PAPP‐A) by bikunin reduces IGF‐I‐dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis

Bikunin Target Genes in Ovarian Cancer Cells Identified by Microarray Analysis

Combined passive and active immunoprophylaxis for preventing perinatal transmission of the hepatitis B virus carrier state in Shizuoka, Japan during 1980-1994

Genetic Down-regulation of Phosphoinositide 3-Kinase by Bikunin Correlates with Suppression of Invasion and Metastasis in Human Ovarian Cancer HRA Cells

Reproductive failure in mice lacking inter-alpha-trypsin inhibitor (ITI) – ITI target genes in mouse ovary identified by microarray analysis

Follicle-Stimulating Hormone and Insulin-Like Growth Factor I Synergistically Induce Up-Regulation of Cartilage Link Protein (Crtl1) via Activation of Phosphatidylinositol-Dependent Kinase/Akt in Rat Granulosa Cells

Bikunin down-regulates heterodimerization between CD44 and growth factor receptors and subsequently suppresses agonist-mediated signaling

Suppression of Urokinase Expression and Invasion by a Soybean Kunitz Trypsin Inhibitor Are Mediated through Inhibition of Src-dependent Signaling Pathways

Bikunin Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Induction in Macrophages

The Idea of the Maternal Protection Act and Its Application: From the standpoint of Japan Association of Obstetricians & Gynecologists

Reduced bikunin gene expression as a factor of poor prognosis in ovarian carcinoma

Kunitz-type Protease Inhibitor Bikunin Disrupts Phorbol Ester-induced Oligomerization of CD44 Variant Isoforms Containing Epitope v9 and Subsequently Suppresses Expression of Urokinase-type Plasminogen Activator in Human Chondrosarcoma Cells

Identity of Urinary Trypsin Inhibitor-binding Protein to Link Protein

Cold-induced stress stimulates the sympathetic nervous system, causing hypertension and proteinuria in rats

Ovarian endometrioma—Risks factors of ovarian cancer development

Clinical Significance of Combined Use of Macrophage Colony-Stimulating Factor and Squamous Cell Carcinoma Antigen as a Selective Diagnostic Marker for Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary

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