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Derivation and Preclinical Characterization of CYT-303, a Novel NKp46-NK Cell Engager Targeting GPC3

Cells (Basel, Switzerland), 2023-03, Vol.12 (7), p.996

2023

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CYT-338 NK Cell Engager Mutispecific Antibody Engagement of NKp46 Activation Receptor Overcomes Anti-CD38 Mab Mediated Fratricide of NK Cells and Accords Enhanced Cancer Immunotherapy

Blood, 2023-11, Vol.142 (Supplement 1), p.6725-6725

2023

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Biological Characterization and Differential Gene Expression Analysis of CYT-338 NK Cell Engager (NKE) Against CD38 Expressing Tumors Including Multiple Myeloma (MM)

Blood, 2022-11, Vol.140 (Supplement 1), p.7068-7069

2022

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Abstract 5667: CYT-303 FLEX-NKTM engager dose response efficacy mechanisms in HCC tumor model and safety in cynomolgus monkey toxicology studies support clinical evaluation in hepato-cellular carcinoma

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.5667-5667

2023

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An improved approach to generate IL-15+/+/TGFβR2−/− iPSC-derived natural killer cells using TALEN

Cell reports methods, 2024-09, Vol.4 (9), p.100857, Article 100857

2024

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Abstract 3436: Novel multifunctional tetravalent CD38 NKp46 FLEX NK࣪ engagers actively target and kill multiple myeloma cells

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3436-3436

2022

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Abstract 2752: Preclinical characterization of FLEX-NK࣪ tetravalent NKp46 engager directed against GPC3 (CYT-303) alone or in combination with iPSC derived Natural Killer cells (iNKs) against hepatocellular carcinoma (HCC)

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2752-2752

2022

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Abstract 3187: Improved anti-tumor immune functions of iPSC-derived NK cells with TGFβR2 knock-out and/or IL-15 knock-in by TALEN® editing for use alone or in combination with GPC3 Flex-NKTM bispecific antibody

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.3187-3187

2023

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323 TALEN®-based gene edited iPSC-derived NK (iNK) cells demonstrate enhanced antitumor activity

Journal for immunotherapy of cancer, 2022-11, Vol.10 (Suppl 2), p.A339-A339

2022

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Abstract PO001: Preclinical activity of glypican-3 (GPC3) and NKp46 directed FLEX-NK™ engager antibody (CYT-303) in combination with iPSC derived natural killer cells (iNKs) or peripheral blood (PB) NK cells in hepatocellular carcinoma (HCC)

Clinical cancer research, 2022-09, Vol.28 (17_Supplement), p.PO001-PO001

2022

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The power of combining iPSC-derived NK cell therapy & NK-cell engager antibodies

Cell and Gene Therapy Insights, 2022-08, Vol.8 (7), p.681-685

2022

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innovation takes the prize

Pharmaceutical Executive, 2007-10, Vol.27 (10), p.65

Teper, Daniel

2007

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Viewpoint

Medical Marketing and Media, 2004-12, Vol.39 (12), p.6

Teper, Daniel

2004

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A deep learning approach to explore the association of age‐related macular degeneration polygenic risk score with retinal optical coherence tomography: A preliminary study

Acta ophthalmologica (Oxford, England), 2024-11, Vol.102 (7), p.e1029-e1039

2024

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Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial

Respiratory research, 2023-05, Vol.24 (1), p.133-133, Article 133

2023

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Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells

Molecular cancer therapeutics, 2012-07, Vol.11 (7), p.1510-1517

2012

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Fundus Image Deep Learning Study to Explore the Association of Retinal Morphology with Age-Related Macular Degeneration Polygenic Risk Score

Biomedicines, 2024-09, Vol.12 (9), p.2092

2024

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Association of Genetic Risk for Age-Related Macular Degeneration with Morphological Features of the Retinal Microvascular Network

Diagnostics (Basel), 2024-04, Vol.14 (7), p.770

2024

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Experiences of healthcare providers with a novel emergency response intubation team during COVID-19

Canadian journal of emergency medicine, 2022-03, Vol.24 (2), p.185-194

2022

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A scoping review of barriers, facilitators and tools to escalation of care processes in the emergency department

Canadian journal of emergency medicine, 2022-04, Vol.24 (3), p.300-312

2022

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Efficacy and Safety of Lampalizumab for Geographic Atrophy Due to Age-Related Macular Degeneration: Chroma and Spectri Phase 3 Randomized Clinical Trials

JAMA ophthalmology, 2018-06, Vol.136 (6), p.666

2018

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An Official American Thoracic Society Clinical Practice Guideline: Classification, Evaluation, and Management of Childhood Interstitial Lung Disease in Infancy

American journal of respiratory and critical care medicine, 2013-08, Vol.188 (3), p.376-394

2013

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MP35-12 IS ANTIBIOTIC PROPHYLAXIS INDICATED FOR TRANSPERINEAL PROSTATE BIOPSY? LOCAL ANTIBIOGRAM FINDINGS TO INFORM ANTIBIOTIC SELECTION

The Journal of urology, 2021-09, Vol.206 (Supplement 3)

2021

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A novel chimeric antigen receptor against prostate stem cell antigen mediates tumor destruction in a humanized mouse model of pancreatic cancer

Human gene therapy, 2014-12, Vol.25 (12), p.1003-1012

2014

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Exhaled nitric oxide predicts loss of asthma control in children after inhaled corticosteroids withdrawal

Pediatric pulmonology, 2019-05, Vol.54 (5), p.537-543

2019

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Derivation and Preclinical Characterization of CYT-303, a Novel NKp46-NK Cell Engager Targeting GPC3

CYT-338 NK Cell Engager Mutispecific Antibody Engagement of NKp46 Activation Receptor Overcomes Anti-CD38 Mab Mediated Fratricide of NK Cells and Accords Enhanced Cancer Immunotherapy

Biological Characterization and Differential Gene Expression Analysis of CYT-338 NK Cell Engager (NKE) Against CD38 Expressing Tumors Including Multiple Myeloma (MM)

Abstract 5667: CYT-303 FLEX-NKTM engager dose response efficacy mechanisms in HCC tumor model and safety in cynomolgus monkey toxicology studies support clinical evaluation in hepato-cellular carcinoma

An improved approach to generate IL-15+/+/TGFβR2−/− iPSC-derived natural killer cells using TALEN

Abstract 3436: Novel multifunctional tetravalent CD38 NKp46 FLEX NK࣪ engagers actively target and kill multiple myeloma cells

Abstract 2752: Preclinical characterization of FLEX-NK࣪ tetravalent NKp46 engager directed against GPC3 (CYT-303) alone or in combination with iPSC derived Natural Killer cells (iNKs) against hepatocellular carcinoma (HCC)

Abstract 3187: Improved anti-tumor immune functions of iPSC-derived NK cells with TGFβR2 knock-out and/or IL-15 knock-in by TALEN® editing for use alone or in combination with GPC3 Flex-NKTM bispecific antibody

323 TALEN®-based gene edited iPSC-derived NK (iNK) cells demonstrate enhanced antitumor activity

Abstract PO001: Preclinical activity of glypican-3 (GPC3) and NKp46 directed FLEX-NK™ engager antibody (CYT-303) in combination with iPSC derived natural killer cells (iNKs) or peripheral blood (PB) NK cells in hepatocellular carcinoma (HCC)

The power of combining iPSC-derived NK cell therapy & NK-cell engager antibodies

innovation takes the prize

Viewpoint

A deep learning approach to explore the association of age‐related macular degeneration polygenic risk score with retinal optical coherence tomography: A preliminary study

Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial

Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells

Fundus Image Deep Learning Study to Explore the Association of Retinal Morphology with Age-Related Macular Degeneration Polygenic Risk Score

Association of Genetic Risk for Age-Related Macular Degeneration with Morphological Features of the Retinal Microvascular Network

Experiences of healthcare providers with a novel emergency response intubation team during COVID-19

A scoping review of barriers, facilitators and tools to escalation of care processes in the emergency department

Efficacy and Safety of Lampalizumab for Geographic Atrophy Due to Age-Related Macular Degeneration: Chroma and Spectri Phase 3 Randomized Clinical Trials

An Official American Thoracic Society Clinical Practice Guideline: Classification, Evaluation, and Management of Childhood Interstitial Lung Disease in Infancy

MP35-12 IS ANTIBIOTIC PROPHYLAXIS INDICATED FOR TRANSPERINEAL PROSTATE BIOPSY? LOCAL ANTIBIOGRAM FINDINGS TO INFORM ANTIBIOTIC SELECTION

A novel chimeric antigen receptor against prostate stem cell antigen mediates tumor destruction in a humanized mouse model of pancreatic cancer

Exhaled nitric oxide predicts loss of asthma control in children after inhaled corticosteroids withdrawal

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