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The molecular functions of hepatocyte nuclear factors – In and beyond the liver

Journal of hepatology, 2018-05, Vol.68 (5), p.1033-1048

2018

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Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells

Nature communications, 2021-05, Vol.12 (1), p.3133-3133, Article 3133

2021

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Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation

Cell reports (Cambridge), 2016-04, Vol.15 (3), p.460-470

2016

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Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

eLife, 2024-01, Vol.13

2024

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Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

Stem cell reports, 2016-03, Vol.6 (3), p.357-367

2016

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Comparable Generation of Activin-Induced Definitive Endoderm via Additive Wnt or BMP Signaling in Absence of Serum

Stem cell reports, 2014-07, Vol.3 (1), p.5-14

2014

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PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells

Stem cell reports, 2015-04, Vol.4 (4), p.578-590

2015

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Manufacturing clinical‐grade human induced pluripotent stem cell‐derived beta cells for diabetes treatment

Cell proliferation, 2022-08, Vol.55 (8), p.e13232-n/a

2022

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Innovations in bio-engineering and cell-based approaches to address immunological challenges in islet transplantation

Frontiers in immunology, 2024-04, Vol.15, p.1375177-1375177

2024

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Pluripotency factors regulate definitive endoderm specification through eomesodermin

Genes & development, 2011-02, Vol.25 (3), p.238-250

2011

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Cell proliferation, 2022-08, Vol.55 (8)

2022

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HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes

Nature communications, 2024-06, Vol.15 (1), p.4288-21, Article 4288

2024

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An arduous journey from human pluripotent stem cells to functional pancreatic β cells

Diabetes, obesity & metabolism, 2018-01, Vol.20 (1), p.3-13

2018

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Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts

Stem cells translational medicine, 2015-10, Vol.4 (10), p.1101-1108

2015

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BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells

Cell death & disease, 2020-05, Vol.11 (5), p.378-378, Article 378

2020

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A new perspective of probe development for imaging pancreatic beta cell in vivo

Seminars in cell & developmental biology, 2020-07, Vol.103, p.3-13

2020

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Metformin from mother to unborn child – Are there unwarranted effects?

EBioMedicine, 2018-09, Vol.35, p.394-404

2018

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New Opportunities: Harnessing Induced Pluripotency for Discovery in Diabetes and Metabolism

Cell metabolism, 2013-12, Vol.18 (6), p.775-791

2013

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HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells

Cell death & disease, 2023-05, Vol.14 (5), p.302-302, Article 302

2023

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PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development

Nature communications, 2023-09, Vol.14 (1), p.6119-6119, Article 6119

2023

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Dynamic proteome profiling of human pluripotent stem cell‐derived pancreatic progenitors

Stem cells (Dayton, Ohio), 2020-04, Vol.38 (4), p.542-555

2020

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Gestational Diabetes Alters Functions in Offspring's Umbilical Cord Cells With Implications for Cardiovascular Health

Endocrinology (Philadelphia), 2017-07, Vol.158 (7), p.2102-2112

2017

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Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation

The Journal of biological chemistry, 2021-01, Vol.296 (C), p.100495-100495, Article 100495

2021

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Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility

Stem cell reports, 2024-05, Vol.19 (5), p.604-617

2024

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FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro

iScience, 2023-08, Vol.26 (8), p.107265-107265, Article 107265

2023

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The molecular functions of hepatocyte nuclear factors – In and beyond the liver

Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells

Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation

Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

Comparable Generation of Activin-Induced Definitive Endoderm via Additive Wnt or BMP Signaling in Absence of Serum

PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells

Manufacturing clinical‐grade human induced pluripotent stem cell‐derived beta cells for diabetes treatment

Innovations in bio-engineering and cell-based approaches to address immunological challenges in islet transplantation

Pluripotency factors regulate definitive endoderm specification through eomesodermin

Featured Cover

HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes

An arduous journey from human pluripotent stem cells to functional pancreatic β cells

Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts

BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells

A new perspective of probe development for imaging pancreatic beta cell in vivo

Metformin from mother to unborn child – Are there unwarranted effects?

New Opportunities: Harnessing Induced Pluripotency for Discovery in Diabetes and Metabolism

HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells

PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development

Dynamic proteome profiling of human pluripotent stem cell‐derived pancreatic progenitors

Gestational Diabetes Alters Functions in Offspring's Umbilical Cord Cells With Implications for Cardiovascular Health

Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation

Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility

FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro

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