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Roflumilast N‐oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro

British journal of pharmacology, 2012-08, Vol.166 (8), p.2243-2262

2012

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Roflumilast inhibits leukocyte–platelet interactions and prevents the prothrombotic functions of polymorphonuclear leukocytes and monocytes

Journal of thrombosis and haemostasis, 2016-01, Vol.14 (1), p.191-204

2016

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Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin‐induced lung injury

British journal of pharmacology, 2009-02, Vol.156 (3), p.534-544

2009

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Roflumilast inhibits the release of chemokines and TNF‐α from human lung macrophages stimulated with lipopolysaccharide

British journal of pharmacology, 2012-03, Vol.165 (6), p.1877-1890

2012

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Roflumilast inhibits leukocyte‐endothelial cell interactions, expression of adhesion molecules and microvascular permeability

British journal of pharmacology, 2007-10, Vol.152 (4), p.481-492

2007

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PDE isoenzymes as targets for anti-asthma drugs

The European respiratory journal, 1995-07, Vol.8 (7), p.1179-1183

1995

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A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro

Pulmonary pharmacology & therapeutics, 2010-08, Vol.23 (4), p.283-291

2010

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The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

Pulmonary pharmacology & therapeutics, 2010-08, Vol.23 (4), p.235-256

2010

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Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors

American journal of physiology. Lung cellular and molecular physiology, 1994-05, Vol.266 (5), p.536-L543

1994

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PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita

Journal of investigative dermatology, 2016-11, Vol.136 (11), p.2211-2220

2016

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Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects

British journal of pharmacology, 1996-08, Vol.118 (7), p.1727-1735

1996

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Cell infiltration, ICAM-1 expression, and eosinophil chemotactic activity in asthmatic sputum

American journal of respiratory and critical care medicine, 1997-02, Vol.155 (2), p.466-472

1997

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Cyclic nucleotide phosphodiesterases from purified human CD4+ and CD8+ T lymphocytes

Clinical and experimental allergy, 1995-07, Vol.25 (7), p.616-624

1995

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Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization

American journal of physiology. Lung cellular and molecular physiology, 1993-05, Vol.264 (5), p.458-L464

1993

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Tumor necrosis factor-α–dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability

Blood, 2005-05, Vol.105 (9), p.3569-3576

2005

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Cyclic nucleotide phosphodiesterase isoenzyme activities in human alveolar macrophages

Clinical and experimental allergy, 1995-07, Vol.25 (7), p.625-633

1995

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Cyclic Nucleotide Phosphodiesterase in Human Bronchial Epithelial Cells: Characterization of Isoenzymes and Functional Effects of PDE Inhibitors

Pulmonary pharmacology & therapeutics, 1998-02, Vol.11 (1), p.47-56

1998

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Roflumilast inhibits the release of chemokines and TNF-[alpha] from human lung macrophages stimulated with lipopolysaccharide

British journal of pharmacology, 2012-03, Vol.165 (6), p.1877

2012

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Identification of Phosphodiesterase IV Activity and Its Cyclic Adenosine Monophosphate-Dependent Up-Regulation in a Human Keratinocyte Cell Line (HaCaT)

Journal of investigative dermatology, 1995-07, Vol.105 (1), p.70-74

1995

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Hyperpermeability of pulmonary endothelial monolayer: protective role of phosphodiesterase isoenzymes 3 and 4

Lung, 1996, Vol.174 (3), p.181-194

1996

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Influence of Phosphodiesterase-Inhibitor PDE4 Roflumilast N-Oxide on Surfactant Protein of human Alveolar Epithelial Cell Type II

Pneumologie (Stuttgart, Germany), 2012, Vol.66 (11)

2012

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Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension

Critical care medicine, 2002-11, Vol.30 (11), p.2489-2492

2002

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Coaerosolization of Phosphodiesterase Inhibitors Markedly Enhances the Pulmonary Vasodilatory Response to Inhaled Iloprost in Experimental Pulmonary Hypertension . Maintenance of Lung Selectivity

American journal of respiratory and critical care medicine, 2001-11, Vol.164 (9), p.1694-1700

2001

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Phosphodiesterase 2 Inhibition Diminished Acute Lung Injury in Murine Pneumococcal Pneumonia

Pneumologie (Stuttgart, Germany), 2008, Vol.62 (S 2)

2008

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Phosphodiesterase 2 Inhibition diminished acute lung injury IN murine Pneumococcal Pneumonia

Pneumologie (Stuttgart, Germany), 2007-12, Vol.61 (12)

2007

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Roflumilast N‐oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro

Roflumilast inhibits leukocyte–platelet interactions and prevents the prothrombotic functions of polymorphonuclear leukocytes and monocytes

Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin‐induced lung injury

Roflumilast inhibits the release of chemokines and TNF‐α from human lung macrophages stimulated with lipopolysaccharide

Roflumilast inhibits leukocyte‐endothelial cell interactions, expression of adhesion molecules and microvascular permeability

PDE isoenzymes as targets for anti-asthma drugs

A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors

PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita

Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects

Cell infiltration, ICAM-1 expression, and eosinophil chemotactic activity in asthmatic sputum

Cyclic nucleotide phosphodiesterases from purified human CD4+ and CD8+ T lymphocytes

Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization

Tumor necrosis factor-α–dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability

Cyclic nucleotide phosphodiesterase isoenzyme activities in human alveolar macrophages

Cyclic Nucleotide Phosphodiesterase in Human Bronchial Epithelial Cells: Characterization of Isoenzymes and Functional Effects of PDE Inhibitors

Roflumilast inhibits the release of chemokines and TNF-[alpha] from human lung macrophages stimulated with lipopolysaccharide

Identification of Phosphodiesterase IV Activity and Its Cyclic Adenosine Monophosphate-Dependent Up-Regulation in a Human Keratinocyte Cell Line (HaCaT)

Hyperpermeability of pulmonary endothelial monolayer: protective role of phosphodiesterase isoenzymes 3 and 4

Influence of Phosphodiesterase-Inhibitor PDE4 Roflumilast N-Oxide on Surfactant Protein of human Alveolar Epithelial Cell Type II

Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension

Coaerosolization of Phosphodiesterase Inhibitors Markedly Enhances the Pulmonary Vasodilatory Response to Inhaled Iloprost in Experimental Pulmonary Hypertension . Maintenance of Lung Selectivity

Phosphodiesterase 2 Inhibition Diminished Acute Lung Injury in Murine Pneumococcal Pneumonia

Phosphodiesterase 2 Inhibition diminished acute lung injury IN murine Pneumococcal Pneumonia

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