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Single‐Arm Clinical Trials as Pivotal Evidence for Cancer Drug Approval: A Retrospective Cohort Study of Centralized European Marketing Authorizations Between 2010 and 2019

Clinical pharmacology and therapeutics, 2020-09, Vol.108 (3), p.653-660

2020

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Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms

PloS one, 2014-04, Vol.9 (4), p.e93473

2014

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Trastuzumab-induced cardiotoxicity and its risk factors in real-world setting of breast cancer patients

Journal of cancer research and clinical oncology, 2018-08, Vol.144 (8), p.1613-1621

2018

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Dasatinib targets c-Src kinase in cardiotoxicity

Toxicology reports, 2023-01, Vol.10, p.521-528

2023

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Societal challenges of precision medicine: Bringing order to chaos

European journal of cancer (1990), 2017-10, Vol.84, p.325-334

2017

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Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats

Cardiovascular research, 2011-01, Vol.89 (1), p.204-213

2011

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(Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function

PloS one, 2012-07, Vol.7 (7), p.e41404

2012

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Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival

Journal of the American Heart Association, 2019-11, Vol.8 (21), p.e013018

2019

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The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression

PloS one, 2015-06, Vol.10 (6), p.e0130502

2015

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WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function

PloS one, 2015-04, Vol.10 (4), p.e0124907-e0124907

2015

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Mitogen-activated Protein Kinases p38 and ERK 1/2 Mediate the Wall Stress-induced Activation of GATA-4 Binding in Adult Heart

The Journal of biological chemistry, 2004-06, Vol.279 (23), p.24852-24860

2004

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European Conditional Marketing Authorization in a Rapidly Evolving Treatment Landscape: A Comprehensive Study of Anticancer Medicinal Products in 2006–2020

Clinical pharmacology and therapeutics, 2023-07, Vol.114 (1), p.148-160

2023

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GATA-4 is an angiogenic survival factor of the infarcted heart

Circulation. Heart failure, 2010-05, Vol.3 (3), p.440-450

2010

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Cell-based therapies for cardiac repair: a meeting report on scientific observations and European regulatory viewpoints

European journal of heart failure, 2016-02, Vol.18 (2), p.133-141

2016

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Mechanisms regulating adrenomedullin gene expression in the left ventricle: role of mechanical load

Regulatory peptides, 2003-04, Vol.112 (1), p.153-159

2003

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Identification of Cell Cycle Regulatory and Inflammatory Genes As Predominant Targets of p38 Mitogen-Activated Protein Kinase in the Heart

Circulation research, 2006-09, Vol.99 (5), p.485-493

2006

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Apelin increases cardiac contractility via protein kinase Cζ- and extracellular signal-regulated kinase-dependent mechanisms

PloS one, 2014-04, Vol.9 (4)

2014

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p38 Kinase rescues failing myocardium after myocardial infarction: evidence for angiogenic and anti‐apoptotic mechanisms

The FASEB journal, 2006-09, Vol.20 (11), p.1907-1909

2006

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Direct left ventricular wall stretch activates GATA4 binding in perfused rat heart: involvement of autocrine/paracrine pathways

Pflügers Archiv, 2002-01, Vol.443 (3), p.362-369

2002

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Abstract 865: Gata-4 Is An Angiogenic Survival Factor Of The Infarcted Heart

Circulation (New York, N.Y.), 2007-10, Vol.116 (suppl_16)

2007

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Apelin Increases Cardiac Contractility via Protein Kinase C epsilon - and Extracellular Signal-Regulated Kinase-Dependent Mechanisms: e93473

PloS one, 2014-04, Vol.9 (4)

2014

Volltextzugriff (PDF)

Abstract 594: Identification of Cell Cycle Regulatory and Inflammatory Genes as Predominant Targets of p38 MAPK in the Heart

Circulation (New York, N.Y.), 2006-10, Vol.114 (suppl_18)

2006

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Posttranscriptional activation of BNP gene expression in response to increased left ventricular wall stress: role of calcineurin and PKC

Regulatory peptides, 2005-06, Vol.128 (3), p.187-196

2005

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Divergent Effects of Losartan and Metoprolol on Cardiac Remodeling, C-kit+ Cells, Proliferation and Apoptosis in the Left Ventricle after Myocardial Infarction

Clinical and translational science, 2009-12, Vol.2 (6), p.422-430

2009

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A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart

Blood pressure, 2010, Vol.19 (1), p.54-63

2010

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Single‐Arm Clinical Trials as Pivotal Evidence for Cancer Drug Approval: A Retrospective Cohort Study of Centralized European Marketing Authorizations Between 2010 and 2019

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms

Trastuzumab-induced cardiotoxicity and its risk factors in real-world setting of breast cancer patients

Dasatinib targets c-Src kinase in cardiotoxicity

Societal challenges of precision medicine: Bringing order to chaos

Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats

(Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function

Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival

The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function

Mitogen-activated Protein Kinases p38 and ERK 1/2 Mediate the Wall Stress-induced Activation of GATA-4 Binding in Adult Heart

European Conditional Marketing Authorization in a Rapidly Evolving Treatment Landscape: A Comprehensive Study of Anticancer Medicinal Products in 2006–2020

GATA-4 is an angiogenic survival factor of the infarcted heart

Cell-based therapies for cardiac repair: a meeting report on scientific observations and European regulatory viewpoints

Mechanisms regulating adrenomedullin gene expression in the left ventricle: role of mechanical load

Identification of Cell Cycle Regulatory and Inflammatory Genes As Predominant Targets of p38 Mitogen-Activated Protein Kinase in the Heart

Apelin increases cardiac contractility via protein kinase Cζ- and extracellular signal-regulated kinase-dependent mechanisms

p38 Kinase rescues failing myocardium after myocardial infarction: evidence for angiogenic and anti‐apoptotic mechanisms

Direct left ventricular wall stretch activates GATA4 binding in perfused rat heart: involvement of autocrine/paracrine pathways

Abstract 865: Gata-4 Is An Angiogenic Survival Factor Of The Infarcted Heart

Apelin Increases Cardiac Contractility via Protein Kinase C epsilon - and Extracellular Signal-Regulated Kinase-Dependent Mechanisms: e93473

Abstract 594: Identification of Cell Cycle Regulatory and Inflammatory Genes as Predominant Targets of p38 MAPK in the Heart

Posttranscriptional activation of BNP gene expression in response to increased left ventricular wall stress: role of calcineurin and PKC

Divergent Effects of Losartan and Metoprolol on Cardiac Remodeling, C-kit+ Cells, Proliferation and Apoptosis in the Left Ventricle after Myocardial Infarction

A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart

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