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Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

Viruses, 2019-04, Vol.11 (4), p.326

2019

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The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

The Journal of biological chemistry, 2020-04, Vol.295 (15), p.4773-4779

2020

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Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template

The Journal of biological chemistry, 2021-07, Vol.297 (1), p.100770-100770, Article 100770

2021

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Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

The Journal of biological chemistry, 2020-05, Vol.295 (20), p.6785-6797

2020

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Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

The Journal of biological chemistry, 2020-11, Vol.295 (47), p.16156-16165

2020

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The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor

The Journal of biological chemistry, 2021-01, Vol.296, p.100486-100486, Article 100486

2021

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Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein

PLoS neglected tropical diseases, 2020-06, Vol.14 (6), p.e0008283-e0008283

2020

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Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus

Scientific reports, 2018-03, Vol.8 (1), p.3970-9, Article 3970

2018

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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Science translational medicine, 2022-08, Vol.14 (656), p.eabo0718

2022

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Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response

Journal of virology, 2017-08, Vol.91 (16)

2017

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Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition

Proceedings of the National Academy of Sciences - PNAS, 2022-07, Vol.119 (27), p.1-e2200260119

2022

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Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (51), p.20509-20513

2011

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Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases

Proceedings of the National Academy of Sciences - PNAS, 2020-10, Vol.117 (43), p.26946-26954

2020

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Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101529-101529, Article 101529

2022

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The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2

Molecules (Basel, Switzerland), 2022-06, Vol.27 (13), p.4212

2022

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Correction: Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

The Journal of biological chemistry, 2021-08, Vol.297 (2), p.101048-101048, Article 101048

2021

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Sandacrabins – Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium

Chemistry : a European journal, 2022-02, Vol.28 (10), p.e202104484-n/a

2022

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Structures, functions and adaptations of the human LINE-1 ORF2 protein

Nature (London), 2024-02, Vol.626 (7997), p.194-206

2024

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Efficient Incorporation and Template‐Dependent Polymerase Inhibition are Major Determinants for the Broad‐Spectrum Antiviral Activity of Remdesivir

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Phosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA Polymerase

The Journal of biological chemistry, 2011-07, Vol.286 (28), p.25246-25255

2011

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The Cysteine Dioxygenase Homologue from Pseudomonas aeruginosa Is a 3-Mercaptopropionate Dioxygenase

The Journal of biological chemistry, 2015-10, Vol.290 (40), p.24424-24437

2015

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A Strongly Bound High-Spin Iron(II) Coordinates Cysteine and Homocysteine in Cysteine Dioxygenase

Biochemistry (Easton), 2012-01, Vol.51 (1), p.257-264

2012

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Mechanistic Implications of Persulfenate and Persulfide Binding in the Active Site of Cysteine Dioxygenase

Biochemistry (Easton), 2013-10, Vol.52 (43), p.7606-7617

2013

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The Cys-Tyr Cross-Link of Cysteine Dioxygenase Changes the Optimal pH of the Reaction without a Structural Change

Biochemistry (Easton), 2014-12, Vol.53 (50), p.7961-7968

2014

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Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs

The Enzymes, 2021, Vol.49, p.315-354

2021

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Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor

Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein

Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition

Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases

Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2

Correction: Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

Sandacrabins – Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium

Structures, functions and adaptations of the human LINE-1 ORF2 protein

Efficient Incorporation and Template‐Dependent Polymerase Inhibition are Major Determinants for the Broad‐Spectrum Antiviral Activity of Remdesivir

Phosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA Polymerase

The Cysteine Dioxygenase Homologue from Pseudomonas aeruginosa Is a 3-Mercaptopropionate Dioxygenase

A Strongly Bound High-Spin Iron(II) Coordinates Cysteine and Homocysteine in Cysteine Dioxygenase

Mechanistic Implications of Persulfenate and Persulfide Binding in the Active Site of Cysteine Dioxygenase

The Cys-Tyr Cross-Link of Cysteine Dioxygenase Changes the Optimal pH of the Reaction without a Structural Change

Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs

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