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Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70)

Current topics in medicinal chemistry, 2016-10, Vol.16 (25), p.2729-2740

2016

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The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in Pseudomonas aeruginosa

Microbiology spectrum, 2022-02, Vol.10 (1), p.e0210821-e0210821

2022

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High-throughput screen for inhibitors of protein–protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex

The Journal of biological chemistry, 2018-03, Vol.293 (11), p.4014-4025

2018

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Protein Interaction Networks of Catalytically Active and Catalytically Inactive PqsE in Pseudomonas aeruginosa

mBio, 2022-10, Vol.13 (5), p.e0155922-e0155922

2022

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A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein–Protein Interactions

ACS chemical biology, 2018-11, Vol.13 (11), p.3142-3152

2018

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A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis

Cell host & microbe, 2019-03, Vol.25 (3), p.454-462.e6

2019

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Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein–Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production

ACS chemical biology, 2021-04, Vol.16 (4), p.740-752

2021

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The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa

Biochemistry (Easton), 2022-09, Vol.61 (17), p.1894-1903

2022

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The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein

The Journal of biological chemistry, 2018-07, Vol.293 (27), p.10796-10809

2018

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Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability

Cell stress & chaperones, 2021-03, Vol.26 (2), p.443-452

2021

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Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer

Cell chemical biology, 2022-03, Vol.29 (3), p.490-501.e4

2022

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Discovery of PqsE Thioesterase Inhibitors for Pseudomonas aeruginosa Using DNA-Encoded Small Molecule Library Screening

ACS chemical biology, 2020-02, Vol.15 (2), p.446-456

2020

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Hetero-multinuclear Ruthenium(III)/Platinum(II) Complexes That Potentially Exhibit Both Antimetastatic and Antineoplastic Properties

Inorganic chemistry, 2012-12, Vol.51 (23), p.12917-12924

2012

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Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells

Chemical science (Cambridge), 2020-01, Vol.11 (7), p.1892-194

2020

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RNA binding and inhibition of primer extension by a Ru(III)/Pt(II) metal complex

Chemical communications (Cambridge, England), 2013-06, Vol.49 (44), p.5031-5033

2013

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Chemical and Genetic Tools for Probing the Cooperativity of Molecular Chaperones

Taylor, Isabelle R

2018

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RNA binding and inhibition of primer extension by a Ru(iii)/Pt(ii) metal complexElectronic supplementary information (ESI) available: Full experimental details, quantified band intensity values, mobility shift assays at varying temperatures, and primer extension controls. See DOI: 10.1039/c3cc40699g

2013-05

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Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

Immunity (Cambridge, Mass.), 2013-04, Vol.38 (4), p.729-741

2013

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The 2019 Raikoke volcanic eruption – Part 1: Dispersion model simulations and satellite retrievals of volcanic sulfur dioxide

Atmospheric chemistry and physics, 2021-07, Vol.21 (14), p.10851-10879

2021

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New Insights Into the Relationship Between Mass Eruption Rate and Volcanic Column Height Based On the IVESPA Data Set

Geophysical research letters, 2023-07, Vol.50 (14), p.1-n/a

2023

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Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele

The New England journal of medicine, 2019-11, Vol.381 (19), p.1809-1819

2019

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Acceptability and feasibility of a screen-and-treat programme for hepatitis B virus infection in The Gambia: the Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) study

The Lancet global health, 2016-08, Vol.4 (8), p.e559-e567

2016

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A satellite chronology of plumes from the April 2021 eruption of La Soufrière, St Vincent

Atmospheric chemistry and physics, 2023-12, Vol.23 (24), p.15209-15234

2023

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Mutations Causing Familial Biparental Hydatidiform Mole Implicate C6orf221 as a Possible Regulator of Genomic Imprinting in the Human Oocyte

American journal of human genetics, 2011-09, Vol.89 (3), p.451-458

2011

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Trial of Prasinezumab in Early-Stage Parkinson’s Disease

The New England journal of medicine, 2022-08, Vol.387 (5), p.421-432

2022

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Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70)

The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in Pseudomonas aeruginosa

High-throughput screen for inhibitors of protein–protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex

Protein Interaction Networks of Catalytically Active and Catalytically Inactive PqsE in Pseudomonas aeruginosa

A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein–Protein Interactions

A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis

Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein–Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production

The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa

The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein

Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability

Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer

Discovery of PqsE Thioesterase Inhibitors for Pseudomonas aeruginosa Using DNA-Encoded Small Molecule Library Screening

Hetero-multinuclear Ruthenium(III)/Platinum(II) Complexes That Potentially Exhibit Both Antimetastatic and Antineoplastic Properties

Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells

RNA binding and inhibition of primer extension by a Ru(III)/Pt(II) metal complex

Chemical and Genetic Tools for Probing the Cooperativity of Molecular Chaperones

RNA binding and inhibition of primer extension by a Ru(iii)/Pt(ii) metal complexElectronic supplementary information (ESI) available: Full experimental details, quantified band intensity values, mobility shift assays at varying temperatures, and primer extension controls. See DOI: 10.1039/c3cc40699g

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

The 2019 Raikoke volcanic eruption – Part 1: Dispersion model simulations and satellite retrievals of volcanic sulfur dioxide

New Insights Into the Relationship Between Mass Eruption Rate and Volcanic Column Height Based On the IVESPA Data Set

Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele

Acceptability and feasibility of a screen-and-treat programme for hepatitis B virus infection in The Gambia: the Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) study

A satellite chronology of plumes from the April 2021 eruption of La Soufrière, St Vincent

Mutations Causing Familial Biparental Hydatidiform Mole Implicate C6orf221 as a Possible Regulator of Genomic Imprinting in the Human Oocyte

Trial of Prasinezumab in Early-Stage Parkinson’s Disease

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