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Targeting hepatic glucose metabolism in the treatment of type 2 diabetes

Nature reviews. Drug discovery, 2016-11, Vol.15 (11), p.786-804

2016

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Insulin regulation of gluconeogenesis

Annals of the New York Academy of Sciences, 2018-01, Vol.1411 (1), p.21-35

2018

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Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer

PloS one, 2012-07, Vol.7 (7), p.e41171-e41171

2012

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Transcriptome-wide analysis of PGC-1α–binding RNAs identifies genes linked to glucagon metabolic action

Proceedings of the National Academy of Sciences - PNAS, 2020-09, Vol.117 (36), p.22204-22213

2020

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Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16), p.3215-3221

2020

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Calcium/Calmodulin Stimulates the Autophosphorylation of Elongation Factor 2 Kinase on Thr-348 and Ser-500 To Regulate Its Activity and Calcium Dependence

Biochemistry (Easton), 2012-03, Vol.51 (11), p.2232-2245

2012

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Investigating the Kinetic Mechanism of Inhibition of Elongation Factor 2 Kinase by NH125: Evidence of a Common in Vitro Artifact

Biochemistry (Easton), 2012-03, Vol.51 (10), p.2100-2112

2012

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Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo

Nature communications, 2019-11, Vol.10 (1), p.5232-15, Article 5232

2019

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Molecular pathophysiology of hepatic glucose production

Molecular aspects of medicine, 2015-12, Vol.46, p.21-33

2015

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Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth

ACS medicinal chemistry letters, 2017-10, Vol.8 (10), p.1072-1076

2017

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A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

Cell metabolism, 2021-03, Vol.33 (3), p.598-614.e7

2021

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H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP

The Journal of clinical investigation, 2020-02, Vol.130 (2), p.853-862

2020

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Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes

Cell, 2017-03, Vol.169 (1), p.148-160.e15

2017

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Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives

Current diabetes reports, 2019-10, Vol.19 (10), p.98-7, Article 98

2019

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High-throughput screens for eEF-2 kinase

Journal of biomolecular screening, 2014-03, Vol.19 (3), p.445-452

2014

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Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors

Bioorganic & medicinal chemistry, 2014-09, Vol.22 (17), p.4910-4916

2014

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Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations

Molecular cell, 2016-10, Vol.64 (1), p.163-175

2016

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Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli

Protein expression and purification, 2011-10, Vol.79 (2), p.237-244

2011

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The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator

The Journal of biological chemistry, 2016-05, Vol.291 (20), p.10635-10645

2016

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Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin

Structure (London), 2016-09, Vol.24 (9), p.1441-1451

2016

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Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION

The Journal of biological chemistry, 2017-02, Vol.292 (5), p.2032-2045

2017

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The Molecular Mechanism of Eukaryotic Elongation Factor 2 Kinase Activation

The Journal of biological chemistry, 2014-08, Vol.289 (34), p.23901-23916

2014

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Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening

Methods in molecular biology (Clifton, N.J.), 2016, Vol.1360, p.19

2016

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Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis

Frontiers in molecular biosciences, 2015-03, Vol.2, p.9-9

2015

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Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine

ACS medicinal chemistry letters, 2015-01, Vol.6 (1), p.47-52

2015

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Targeting hepatic glucose metabolism in the treatment of type 2 diabetes

Insulin regulation of gluconeogenesis

Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer

Transcriptome-wide analysis of PGC-1α–binding RNAs identifies genes linked to glucagon metabolic action

Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency

Calcium/Calmodulin Stimulates the Autophosphorylation of Elongation Factor 2 Kinase on Thr-348 and Ser-500 To Regulate Its Activity and Calcium Dependence

Investigating the Kinetic Mechanism of Inhibition of Elongation Factor 2 Kinase by NH125: Evidence of a Common in Vitro Artifact

Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo

Molecular pathophysiology of hepatic glucose production

Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth

A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes

Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives

High-throughput screens for eEF-2 kinase

Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors

Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations

Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli

The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator

Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin

Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION

The Molecular Mechanism of Eukaryotic Elongation Factor 2 Kinase Activation

Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening

Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis

Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine

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