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Discovery of antitumor effects of leczymes

Glycoconjugate journal, 2022-04, Vol.39 (2), p.157-165

2022

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がん治療への応用を目指したウシガエル卵由来シアル酸結合性レクチン（cSBL）の基礎研究

YAKUGAKU ZASSHI, 2022/10/01, Vol.142(10), pp.1045-1053

立田, 岳生

2022

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Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo

PloS one, 2018-01, Vol.13 (1), p.e0190653-e0190653

2018

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Catfish Egg Lectin Enhances the Cytotoxicity of Sunitinib on Gb3-Expressing Renal Cancer Cells

Biomedicines, 2023-08, Vol.11 (8), p.2317

2023

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Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells

Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2714

2018

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Catfish egg lectin affects influx and efflux rates of sunitinib in human cervical carcinoma HeLa cells

Glycobiology (Oxford), 2020-09, Vol.30 (10), p.802-816

2020

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Editorial: Drug-resistance in cancer cells: A new wine in an old bottle

Frontiers in oncology, 2023-02, Vol.13, p.1161008-1161008

2023

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Synergistic anti-tumor effect of bullfrog sialic acid-binding lectin and pemetrexed in malignant mesothelioma

Oncotarget, 2017-06, Vol.8 (26), p.42466-42477

2017

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Sialidase NEU3 Contributes to the Invasiveness of Bladder Cancer

Biomedicines, 2024-01, Vol.12 (1), p.192

2024

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Basic Research on Bullfrog Egg-derived Sialic Acid-binding Lectin for Cancer Treatment

YAKUGAKU ZASSHI, 2022/10/01, Vol.142(10), pp.1045-1053

Tatsuta, Takeo

2022

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Lissoclibadin 1, a Polysulfur Aromatic Alkaloid from the Indonesian Ascidian Lissoclinum cf. badium, Induces Caspase-Dependent Apoptosis in Human Colon Cancer Cells and Suppresses Tumor Growth in Nude Mice

Journal of natural products (Washington, D.C.), 2017-02, Vol.80 (2), p.499-502

2017

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RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells

International journal of oncology, 2016-10, Vol.49 (4), p.1334-1342

2016

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Sialic acid-binding lectin (leczyme) induces caspase-dependent apoptosis-mediated mitochondrial perturbation in Jurkat cells

International journal of oncology, 2013-11, Vol.43 (5), p.1402-1412

2013

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Involvement of ER stress in apoptosis induced by sialic acid-binding lectin (leczyme) from bullfrog eggs

International journal of oncology, 2013-12, Vol.43 (6), p.1799-1808

2013

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Catfish rhamnose-binding lectin induces G0/1 cell cycle arrest in Burkitt’s lymphoma cells via membrane surface Gb3

Glycoconjugate journal, 2017-02, Vol.34 (1), p.127-138

2017

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Downregulation of Hsp70 inhibits apoptosis induced by sialic acid-binding lectin (leczyme)

Oncology reports, 2014-01, Vol.31 (1), p.13-18

2014

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Leczyme : A New Candidate Drug for Cancer Therapy

BioMed research international, 2014-01, Vol.2014 (2014), p.1-10

2014

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Binding of Silurus asotus lectin to Gb3 on Raji cells causes disappearance of membrane-bound form of HSP70

Biochimica et biophysica acta, 2009-02, Vol.1790 (2), p.101-109

2009

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Binding profiles and cytokine-inducing effects of fish rhamnose-binding lectins on Burkitt’s lymphoma Raji cells

Fish physiology and biochemistry, 2014-10, Vol.40 (5), p.1559-1572

2014

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Cancer-selective induction of apoptosis by leczyme

Frontiers in oncology, 2014-01, Vol.4, p.139-139

2014

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Alteration of Gene Expression Induced by Silurus asotus Lectin in Burkitt's Lymphoma Cells

Biological and Pharmaceutical Bulletin, 2008/05/01, Vol.31(5), pp.998-1002

2008

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Domain composition of rhamnose-binding lectin from shishamo smelt eggs and its carbohydrate-binding profiles

Fish physiology and biochemistry, 2013-12, Vol.39 (6), p.1619-1630

2013

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Globotriaosylceramide-Expressing Burkitt's Lymphoma Cells Are Committed to Early Apoptotic Status by Rhamnose-Binding Lectin from Catfish Eggs

Biological and Pharmaceutical Bulletin, 2009/03/01, Vol.32(3), pp.345-353

2009

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Bacterial Expression of Rhamnose-Binding Lectin from Catfish Eggs

Methods in molecular biology (Clifton, N.J.), 2020, Vol.2132, p.359

2020

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Transcriptomic alterations in malignant pleural mesothelioma cells in response to long‑term treatment with bullfrog sialic acid‑binding lectin

Molecular medicine reports, 2021-06, Vol.23 (6), Article 467

2021

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Discovery of antitumor effects of leczymes

がん治療への応用を目指したウシガエル卵由来シアル酸結合性レクチン（cSBL）の基礎研究

Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo

Catfish Egg Lectin Enhances the Cytotoxicity of Sunitinib on Gb3-Expressing Renal Cancer Cells

Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells

Catfish egg lectin affects influx and efflux rates of sunitinib in human cervical carcinoma HeLa cells

Editorial: Drug-resistance in cancer cells: A new wine in an old bottle

Synergistic anti-tumor effect of bullfrog sialic acid-binding lectin and pemetrexed in malignant mesothelioma

Sialidase NEU3 Contributes to the Invasiveness of Bladder Cancer

Basic Research on Bullfrog Egg-derived Sialic Acid-binding Lectin for Cancer Treatment

Lissoclibadin 1, a Polysulfur Aromatic Alkaloid from the Indonesian Ascidian Lissoclinum cf. badium, Induces Caspase-Dependent Apoptosis in Human Colon Cancer Cells and Suppresses Tumor Growth in Nude Mice

RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells

Sialic acid-binding lectin (leczyme) induces caspase-dependent apoptosis-mediated mitochondrial perturbation in Jurkat cells

Involvement of ER stress in apoptosis induced by sialic acid-binding lectin (leczyme) from bullfrog eggs

Catfish rhamnose-binding lectin induces G0/1 cell cycle arrest in Burkitt’s lymphoma cells via membrane surface Gb3

Downregulation of Hsp70 inhibits apoptosis induced by sialic acid-binding lectin (leczyme)

Leczyme : A New Candidate Drug for Cancer Therapy

Binding of Silurus asotus lectin to Gb3 on Raji cells causes disappearance of membrane-bound form of HSP70

Binding profiles and cytokine-inducing effects of fish rhamnose-binding lectins on Burkitt’s lymphoma Raji cells

Cancer-selective induction of apoptosis by leczyme

Alteration of Gene Expression Induced by Silurus asotus Lectin in Burkitt's Lymphoma Cells

Domain composition of rhamnose-binding lectin from shishamo smelt eggs and its carbohydrate-binding profiles

Globotriaosylceramide-Expressing Burkitt's Lymphoma Cells Are Committed to Early Apoptotic Status by Rhamnose-Binding Lectin from Catfish Eggs

Bacterial Expression of Rhamnose-Binding Lectin from Catfish Eggs

Transcriptomic alterations in malignant pleural mesothelioma cells in response to long‑term treatment with bullfrog sialic acid‑binding lectin

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