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Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant: Lead Identification and SAR of 3- and 4-Substituted Derivatives

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.1034-1040

2000

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Association of Integrase, Matrix, and Reverse Transcriptase Antigens of Human Immunodeficiency Virus Type 1 with Viral Nucleic Acids Following Acute Infection

Proceedings of the National Academy of Sciences - PNAS, 1993-07, Vol.90 (13), p.6125-6129

1993

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Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor

Antimicrobial Agents and Chemotherapy, 1997-05, Vol.41 (5), p.1058-1063

1997

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A Mutation in Reverse Transcriptase of Bis(heteroaryl)Piperazine-Resistant Human Immunodeficiency Virus Type 1 that Confers Increased Sensitivity to Other Nonnucleoside Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 1993-05, Vol.90 (10), p.4713-4717

1993

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An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection

Proceedings of the National Academy of Sciences - PNAS, 1990-10, Vol.87 (19), p.7472-7476

1990

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Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy

Journal of Virology, 1993-09, Vol.67 (9), p.5353-5359

1993

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A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation

Science (American Association for the Advancement of Science), 1990-01, Vol.247 (4941), p.454-456

1990

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Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

Journal of medicinal chemistry, 1998-09, Vol.41 (20), p.3793-3803

1998

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The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase

Biochemical pharmacology, 1996-03, Vol.51 (6), p.743-750

1996

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(-)-6-chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor

Journal of medicinal chemistry, 1998-04, Vol.41 (9), p.1357-1360

1998

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U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication

Antimicrobial Agents and Chemotherapy, 1993-05, Vol.37 (5), p.1127-1131

1993

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Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors

Journal of medicinal chemistry, 1996-09, Vol.39 (19), p.3769-3789

1996

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The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase

The Journal of biological chemistry, 1992-01, Vol.267 (1), p.27-30

1992

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Loss of Platelet-Derived Growth Factor-Stimulated Phospholipase Activity in NIH-3T3 Cells Expressing the EJ-ras Oncogene

Proceedings of the National Academy of Sciences - PNAS, 1987-01, Vol.84 (2), p.546-550

1987

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Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors

Virology (New York, N.Y.), 1992-09, Vol.190 (1), p.269-277

1992

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Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E

The Journal of biological chemistry, 1993-03, Vol.268 (9), p.6119-6124

1993

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Reduced Hormone-Stimulated Adenylate Cyclase Activity in NIH-3T3 Cells Expressing the EJ Human Bladder ras Oncogene

Proceedings of the National Academy of Sciences - PNAS, 1986-06, Vol.83 (11), p.3703-3707

1986

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Inhibition of the protease of human immunodeficiency virus blocks replication and infectivity of the virus in chronically infected macrophages

The Journal of infectious diseases, 1993-11, Vol.168 (5), p.1148-1156

1993

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Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase

Biochemistry (Easton), 1991-03, Vol.30 (10), p.2651-2655

1991

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Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2344-2356

1991

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A recombinant ribonuclease H domain of HIV-1 reverse transcriptase that is enzymatically active

The Journal of biological chemistry, 1991-11, Vol.266 (31), p.20583-20585

1991

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The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase

The Journal of biological chemistry, 1993-07, Vol.268 (20), p.14875-14880

1993

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Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]piperazine monomethanesulfonate (U-90152S), a second-generation clinical candidate

Journal of medicinal chemistry, 1993-05, Vol.36 (10), p.1505-1508

1993

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Nonnucleoside Reverse Transcriptase Inhibitors that Potently and Specifically Block Human Immunodeficiency Virus Type 1 Replication

Proceedings of the National Academy of Sciences - PNAS, 1991-10, Vol.88 (19), p.8806-8810

1991

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The location of v-src in a retrovirus vector determines whether the virus is toxic or transforming

Molecular and Cellular Biology, 1984-12, Vol.4 (12), p.2653-2660

1984

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Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant: Lead Identification and SAR of 3- and 4-Substituted Derivatives

Association of Integrase, Matrix, and Reverse Transcriptase Antigens of Human Immunodeficiency Virus Type 1 with Viral Nucleic Acids Following Acute Infection

Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor

A Mutation in Reverse Transcriptase of Bis(heteroaryl)Piperazine-Resistant Human Immunodeficiency Virus Type 1 that Confers Increased Sensitivity to Other Nonnucleoside Inhibitors

An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy

A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation

Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase

(-)-6-chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor

U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication

Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors

The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase

Loss of Platelet-Derived Growth Factor-Stimulated Phospholipase Activity in NIH-3T3 Cells Expressing the EJ-ras Oncogene

Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors

Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E

Reduced Hormone-Stimulated Adenylate Cyclase Activity in NIH-3T3 Cells Expressing the EJ Human Bladder ras Oncogene

Inhibition of the protease of human immunodeficiency virus blocks replication and infectivity of the virus in chronically infected macrophages

Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase

Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity

A recombinant ribonuclease H domain of HIV-1 reverse transcriptase that is enzymatically active

The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase

Nonnucleoside Reverse Transcriptase Inhibitors that Potently and Specifically Block Human Immunodeficiency Virus Type 1 Replication

The location of v-src in a retrovirus vector determines whether the virus is toxic or transforming

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