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Avoiding Clinical Trial Failures in Neglected Tropical Diseases: The Example of Chagas Disease

Clinical infectious diseases, 2023-04, Vol.76 (8), p.1516-1520

Tarleton, Rick L

2023

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CD8+ T cells in Trypanosoma cruzi infection

Seminars in immunopathology, 2015-05, Vol.37 (3), p.233-238

Tarleton, Rick L.

2015

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Effective drug discovery in Chagas disease

Trends in parasitology, 2023-06, Vol.39 (6), p.423-431

Tarleton, Rick L.

2023

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Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

eLife, 2018-03, Vol.7

2018

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Chagas Disease: A solvable problem, Ignored

Trends in molecular medicine, 2016-10, Vol.22 (10), p.835-838

Tarleton, Rick L

2016

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cGAS-STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control

The Journal of immunology (1950), 2023-10, Vol.211 (7), p.1123-1133

2023

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Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection

PLoS pathogens, 2018-11, Vol.14 (11), p.e1007410-e1007410

2018

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Immune system recognition of Trypanosoma cruzi

Current Opinion in Immunology, 2007-08, Vol.19 (4), p.430-434

Tarleton, Rick L

2007

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CRISPR-Cas9-mediated single-gene and gene family disruption in Trypanosoma cruzi

mBio, 2014-12, Vol.6 (1), p.e02097-e02014

2014

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Protozoan persister-like cells and drug treatment failure

Nature reviews. Microbiology, 2019-10, Vol.17 (10), p.607-620

2019

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Chromosome level assembly of the hybrid Trypanosoma cruzi genome

BMC genomics, 2009-06, Vol.10 (255), p.255-255, Article 255

2009

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The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi

BMC genomics, 2009-08, Vol.10 (1), p.370-370, Article 370

2009

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The Trypanosoma cruzi Flagellum Is Discarded via Asymmetric Cell Division following Invasion and Provides Early Targets for Protective CD8+ T Cells

Cell host & microbe, 2014-10, Vol.16 (4), p.439-449

2014

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The challenges of Chagas Disease-- grim outlook or glimmer of hope

PLoS medicine, 2007-12, Vol.4 (12), p.e332-e332

2007

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A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease

Science translational medicine, 2020-10, Vol.12 (567)

2020

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Positive clinical outcome using a modified dosing regimen of benznidazole in dogs at high risk for infection or acutely infected with Trypanosoma cruzi

Journal of veterinary internal medicine, 2024-05, Vol.38 (3), p.1725-1729

2024

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Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization

BMC genomics, 2011-03, Vol.12 (1), p.139-139, Article 139

2011

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High variation in immune responses and parasite phenotypes in naturally acquired Trypanosoma cruzi infection in a captive non-human primate breeding colony in Texas, USA

PLoS neglected tropical diseases, 2021-03, Vol.15 (3), p.e0009141-e0009141

2021

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A systematic review of high quality diagnostic tests for Chagas disease

PLoS neglected tropical diseases, 2012-11, Vol.6 (11), p.e1881-e1881

2012

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In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds

PLoS neglected tropical diseases, 2010-07, Vol.4 (7), p.e740

2010

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Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins

mBio, 2017-11, Vol.8 (6)

2017

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Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion

The Journal of immunology (1950), 2020-08, Vol.205 (3), p.573-578

2020

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Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi

BMC genomics, 2016-09, Vol.17 (1), p.729-729, Article 729

2016

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New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma cruzi Infection in Mice

The Journal of infectious diseases, 2014-01, Vol.209 (1), p.150-162

2014

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Drug-induced cure drives conversion to a stable and protective CD8 + T central memory response in chronic Chagas disease

Nature medicine, 2008-05, Vol.14 (5), p.542-550

2008

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Avoiding Clinical Trial Failures in Neglected Tropical Diseases: The Example of Chagas Disease

CD8+ T cells in Trypanosoma cruzi infection

Effective drug discovery in Chagas disease

Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

Chagas Disease: A solvable problem, Ignored

cGAS-STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control

Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection

Immune system recognition of Trypanosoma cruzi

CRISPR-Cas9-mediated single-gene and gene family disruption in Trypanosoma cruzi

Protozoan persister-like cells and drug treatment failure

Chromosome level assembly of the hybrid Trypanosoma cruzi genome

The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi

The Trypanosoma cruzi Flagellum Is Discarded via Asymmetric Cell Division following Invasion and Provides Early Targets for Protective CD8+ T Cells

The challenges of Chagas Disease-- grim outlook or glimmer of hope

A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease

Positive clinical outcome using a modified dosing regimen of benznidazole in dogs at high risk for infection or acutely infected with Trypanosoma cruzi

Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization

High variation in immune responses and parasite phenotypes in naturally acquired Trypanosoma cruzi infection in a captive non-human primate breeding colony in Texas, USA

A systematic review of high quality diagnostic tests for Chagas disease

In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds

Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins

Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion

Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi

New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma cruzi Infection in Mice

Drug-induced cure drives conversion to a stable and protective CD8 + T central memory response in chronic Chagas disease

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