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Structural Basis for Bisphosphonate-mediated Inhibition of Isoprenoid Biosynthesis

The Journal of biological chemistry, 2004-03, Vol.279 (10), p.8526-8529

2004

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X-ray Crystallographic Structures of the Escherichia coli Periplasmic Protein FhuD Bound to Hydroxamate-type Siderophores and the Antibiotic Albomycin

The Journal of biological chemistry, 2002-04, Vol.277 (16), p.13966-13972

2002

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Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents

PloS one, 2013-12, Vol.8 (12), p.e84409-e84409

2013

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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1529-1536

2013

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Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases

Structure (London), 2004-07, Vol.12 (7), p.1325-1334

2004

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Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:l-Alanine Ligase (MurC) from Haemophilus influenzae

Journal of Bacteriology, 2003-07, Vol.185 (14), p.4152-4162

2003

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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1537-1543

2013

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High-affinity binding by the periplasmic iron-binding protein from Haemophilus influenzae is required for acquiring iron from transferrin

Biochemical journal, 2007-06, Vol.404 (2), p.217-225

2007

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The role of the synergistic phosphate anion in iron transport by the periplasmic iron-binding protein from Haemophilus influenzae

Biochemical journal, 2007-04, Vol.403 (1), p.43-48

2007

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Dynamic Light Scattering Study of Calmodulin–Target Peptide Complexes

Biophysical journal, 2002-09, Vol.83 (3), p.1455-1464

2002

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Structural Basis for Iron Binding and Release by a Novel Class of Periplasmic Iron-Binding Proteins Found in Gram-Negative Pathogens

Journal of Bacteriology, 2004-06, Vol.186 (12), p.3903-3910

2004

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Novel Anion-independent Iron Coordination by Members of a Third Class of Bacterial Periplasmic Ferric Ion-binding Proteins

The Journal of biological chemistry, 2005-02, Vol.280 (7), p.5820-5827

2005

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High Resolution Structure of an Alternate Form of the Ferric Ion Binding Protein from Haemophilus influenzae

The Journal of biological chemistry, 2003-03, Vol.278 (13), p.11513-11519

2003

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1195 Discovery of CBO421, a first-in-class drug Fc-conjugate (DFC), targeting CD73 in cancer

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1318-A1318

2023

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Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (10), p.3138-3141

2010

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Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications

Phytochemistry, 2000-05, Vol.54 (2), p.121-138

2000

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Crystal Structure of Pasteurella haemolytica Ferric Ion-binding Protein A Reveals a Novel Class of Bacterial Iron-binding Proteins

The Journal of biological chemistry, 2003-10, Vol.278 (42), p.41093-41098

2003

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How do kinases transfer phosphoryl groups?

Structure, 1998-04, Vol.6 (4), p.413-419

1998

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The structure of the ferric siderophore binding protein FhuD complexed with gallichrome

Nature structural & molecular biology, 2000-04, Vol.7 (4), p.287-291

2000

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Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.688-691

2007

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Structure and Mechanism of Phosphoenolpyruvate Carboxykinase

The Journal of biological chemistry, 1997-03, Vol.272 (13), p.8105-8108

1997

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The utility of structural biology in drug discovery

Methods in molecular biology (Clifton, N.J.), 2012, Vol.841, p.1

Tari, Leslie W

2012

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The use of molecular graphics in structure-based drug design

Methods in molecular biology (Clifton, N.J.), 2012-01, Vol.841, p.143

2012

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Protein crystallization for structure-based drug design

Methods in molecular biology (Clifton, N.J.), 2012-01, Vol.841, p.67

Hoffman, Isaac D

2012

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Accounting for solvent in structure-based drug design

Methods in molecular biology (Clifton, N.J.), 2012, Vol.841, p.251

Tari, Leslie W

2012

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Structural Basis for Bisphosphonate-mediated Inhibition of Isoprenoid Biosynthesis

X-ray Crystallographic Structures of the Escherichia coli Periplasmic Protein FhuD Bound to Hydroxamate-type Siderophores and the Antibiotic Albomycin

Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases

Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:l-Alanine Ligase (MurC) from Haemophilus influenzae

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity

High-affinity binding by the periplasmic iron-binding protein from Haemophilus influenzae is required for acquiring iron from transferrin

The role of the synergistic phosphate anion in iron transport by the periplasmic iron-binding protein from Haemophilus influenzae

Dynamic Light Scattering Study of Calmodulin–Target Peptide Complexes

Structural Basis for Iron Binding and Release by a Novel Class of Periplasmic Iron-Binding Proteins Found in Gram-Negative Pathogens

Novel Anion-independent Iron Coordination by Members of a Third Class of Bacterial Periplasmic Ferric Ion-binding Proteins

High Resolution Structure of an Alternate Form of the Ferric Ion Binding Protein from Haemophilus influenzae

1195 Discovery of CBO421, a first-in-class drug Fc-conjugate (DFC), targeting CD73 in cancer

Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity

Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications

Crystal Structure of Pasteurella haemolytica Ferric Ion-binding Protein A Reveals a Novel Class of Bacterial Iron-binding Proteins

How do kinases transfer phosphoryl groups?

The structure of the ferric siderophore binding protein FhuD complexed with gallichrome

Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors

Structure and Mechanism of Phosphoenolpyruvate Carboxykinase

The utility of structural biology in drug discovery

The use of molecular graphics in structure-based drug design

Protein crystallization for structure-based drug design

Accounting for solvent in structure-based drug design

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