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Current approaches for ADME characterization of antibody-drug conjugates: An industry white paper

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S5-S5

Tarcsa, Edit

2017

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Citrullination: A posttranslational modification in health and disease

The international journal of biochemistry & cell biology, 2006, Vol.38 (10), p.1662-1677

2006

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Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models

Neurobiology of disease, 2021-11, Vol.159, p.105492, Article 105492

2021

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Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin

Nature biotechnology, 2007-11, Vol.25 (11), p.1290-1297

2007

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Off-target binding of an anti-amyloid beta monoclonal antibody to platelet factor 4 causes acute and chronic toxicity in cynomolgus monkeys

mAbs, 2021-01, Vol.13 (1), p.1887628

2021

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Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper

Molecular therapy. Methods & clinical development, 2022-09, Vol.26, p.471-494

2022

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Analysis of chloroquine and metabolites directly from whole-body animal tissue sections by liquid extraction surface analysis (LESA) and tandem mass spectrometry

Journal of mass spectrometry., 2012-11, Vol.47 (11), p.1420-1428

2012

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ADME of biologics

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S1-S1

Tarcsa, Edit

2017

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Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig

Protein & cell, 2018-01, Vol.9 (1), p.121-129

2018

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A high throughput capillary electrophoresis method to obtain pharmacokinetics and quality attributes of a therapeutic molecule in circulation

mAbs, 2012-07, Vol.4 (4), p.521-531

2012

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Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.617-623

2016

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Biochemical, Structural, and Transglutaminase Substrate Properties Of Human Loricrin, the Major Epidermal Cornified Cell Envelope Protein (∗)

The Journal of biological chemistry, 1995-11, Vol.270 (44), p.26382-26390

1995

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An IQ Consortium Perspective on Best Practices for Bioanalytical and Immunogenicity Assessment Aspects of CAR‐T and TCR‐T Cellular Therapies Development

Clinical pharmacology and therapeutics, 2024-02, Vol.115 (2), p.188-200

2024

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A Highly Conserved Lysine Residue on the Head Domain of Type II Keratins is Essential for the Attachment of Keratin Intermediate Filaments to the Cornified cell Envelope through Isopeptide Crosslinking by Transglutaminases

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (5), p.2067-2072

1998

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Quantitation of a recombinant monoclonal antibody in monkey serum by liquid chromatography–mass spectrometry

Analytical biochemistry, 2011-07, Vol.414 (1), p.147-153

2011

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Antibody-drug conjugates as targeted therapies: Are we there yet? A critical review of the current clinical landscape

Drug discovery today. Technologies, 2020-12, Vol.37, p.13-22

2020

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Structural and Transglutaminase Substrate Properties of the Small Proline-rich 2 Family of Cornified Cell Envelope Proteins

The Journal of biological chemistry, 1998-09, Vol.273 (36), p.23297-23303

1998

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Preexisting antibody assays for gene therapy: Considerations on patient selection cutoffs and companion diagnostic requirements

Molecular therapy. Methods & clinical development, 2024-03, Vol.32 (1), p.101217-101217, Article 101217

2024

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Non-clinical Safety Evaluation of Biotherapeutics – Challenges, Opportunities and new Insights

Regulatory toxicology and pharmacology, 2016-10, Vol.80, p.S1-S14

2016

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Transglutaminase crosslinking and structural studies of the human small proline rich 3 protein

Cell death and differentiation, 1999-09, Vol.6 (9), p.916-930

1999

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Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β

mAbs, 2015-05, Vol.7 (3), p.605-619

2015

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Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (20), p.4399-4404

2015

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The Bcl-2 Family Antagonist ABT-737 Significantly Inhibits Multiple Animal Models of Autoimmunity

The Journal of immunology (1950), 2009-06, Vol.182 (12), p.7482-7489

2009

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Ca2+-free Calmodulin and Calmodulin Damaged byin Vitro Aging Are Selectively Degraded by 26 S Proteasomes without Ubiquitination

The Journal of biological chemistry, 2000-07, Vol.275 (27), p.20295-20301

2000

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The unfolding of substrates and ubiquitin-independentprotein degradation by proteasomes

Biochimie, 2001-03, Vol.83 (3), p.311-318

2001

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Current approaches for ADME characterization of antibody-drug conjugates: An industry white paper

Citrullination: A posttranslational modification in health and disease

Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models

Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin

Off-target binding of an anti-amyloid beta monoclonal antibody to platelet factor 4 causes acute and chronic toxicity in cynomolgus monkeys

Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper

Analysis of chloroquine and metabolites directly from whole-body animal tissue sections by liquid extraction surface analysis (LESA) and tandem mass spectrometry

ADME of biologics

Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig

A high throughput capillary electrophoresis method to obtain pharmacokinetics and quality attributes of a therapeutic molecule in circulation

Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper

Biochemical, Structural, and Transglutaminase Substrate Properties Of Human Loricrin, the Major Epidermal Cornified Cell Envelope Protein (∗)

An IQ Consortium Perspective on Best Practices for Bioanalytical and Immunogenicity Assessment Aspects of CAR‐T and TCR‐T Cellular Therapies Development

A Highly Conserved Lysine Residue on the Head Domain of Type II Keratins is Essential for the Attachment of Keratin Intermediate Filaments to the Cornified cell Envelope through Isopeptide Crosslinking by Transglutaminases

Quantitation of a recombinant monoclonal antibody in monkey serum by liquid chromatography–mass spectrometry

Antibody-drug conjugates as targeted therapies: Are we there yet? A critical review of the current clinical landscape

Structural and Transglutaminase Substrate Properties of the Small Proline-rich 2 Family of Cornified Cell Envelope Proteins

Preexisting antibody assays for gene therapy: Considerations on patient selection cutoffs and companion diagnostic requirements

Non-clinical Safety Evaluation of Biotherapeutics – Challenges, Opportunities and new Insights

Transglutaminase crosslinking and structural studies of the human small proline rich 3 protein

Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β

Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors

The Bcl-2 Family Antagonist ABT-737 Significantly Inhibits Multiple Animal Models of Autoimmunity

Ca2+-free Calmodulin and Calmodulin Damaged byin Vitro Aging Are Selectively Degraded by 26 S Proteasomes without Ubiquitination

The unfolding of substrates and ubiquitin-independentprotein degradation by proteasomes

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