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Mild and General Methods for the Palladium-Catalyzed Cyanation of Aryl and Heteroaryl Chlorides

Organic letters, 2007-04, Vol.9 (9), p.1711-1714

2007

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Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors

Current topics in medicinal chemistry, 2004-06, Vol.4 (10), p.1045

Tarby, Christine M

2004

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Modulation of cofilin phosphorylation by inhibition of the Lim family kinases

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (18), p.5995-5998

2012

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Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (8), p.2095-2100

2006

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Potent antagonists of the CCR2b receptor. Part 3: SAR of the ( R)-3-aminopyrrolidine series

Bioorganic & medicinal chemistry letters, 2008-03, Vol.18 (6), p.1869-1873

2008

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Generalized Dipeptidomimetic Template: Solution Phase Parallel Synthesis of Combinatorial Libraries

Journal of the American Chemical Society, 1996-02, Vol.118 (8), p.2109-2110

1996

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Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (21), p.5413-5416

2004

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Opportunities for novel therapeutic agents acting at chemokine receptors

Drug Discovery Today, 1999-02, Vol.4 (2), p.80-92

1999

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Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (21), p.5407-5411

2004

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Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology

ACS medicinal chemistry letters, 2024-02, Vol.15 (2), p.189-196

2024

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Chemical and Structural Comparison of N-BOC-CBQ and N-BOC-CBI: Identification and Structural Origin of an Unappreciated but Productive Stability of the CC-1065 and Duocarmycin SA Alkylation Subunits

Journal of the American Chemical Society, 1994-07, Vol.116 (14), p.6461-6462

1994

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Synthesis, Chemical Properties, and Preliminary Evaluation of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Cyano-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one Alkylation Subunit: Hammett Quantitation of the Magnitude of Electronic Effects on Functional Reactivity

Journal of organic chemistry, 1996-07, Vol.61 (15), p.4894-4912

1996

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Abstract 5395: Anti-tumor activity of BMS-595, a novel CK2 kinase inhibitor

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5395-5395

2015

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Abstract 5417: The identification of BMS-595, an orally active imidazo[1,2-b]pyridazine CK2 inhibitor with in vivo anti-tumor activity

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5417-5417

2015

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Assessing compound binding to the Eg5 motor domain using a thermal shift assay

Analytical biochemistry, 2009-09, Vol.392 (1), p.59-69

2009

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Design, synthesis and structure–activity relationships of novel biarylamine-based Met kinase inhibitors

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (9), p.2998-3002

2010

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A Hammett correlation for CC-1065 and duocarmycin analogs: Magnitude of substituent electronic effects on functional reactivity

Bioorganic & medicinal chemistry letters, 1996-03, Vol.6 (6), p.659-664

1996

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A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: A universal and dipeptide mimetic template

Bioorganic & medicinal chemistry, 1996-05, Vol.4 (5), p.727-737

1996

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Molecular basis for sequence selective DNA alkylation by (+)- and ent-(−)-CC-1065 and related agents: Alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity

Bioorganic & medicinal chemistry, 1994-02, Vol.2 (2), p.115-135

1994

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Solid-phase synthesis of potential aspartic acid protease inhibitors containing a hydroxyethylamine isostere

Tetrahedron letters, 1999-04, Vol.40 (14), p.2729-2732

1999

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Molecular diversity and solid-phase synthesis

Drug discovery today, 1996-04, Vol.1 (4), p.132-133

1996

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Steric and Electronic Effects Controlling the Synthesis of Bridgehead Nitrogen Heterocycles

Heterocycles, 1993-05, Vol.35 (2), p.763

1993

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I. The synthesis and preliminary evaluation of the CCBI alkylation subunit and its extended agents, potent CBI-based analogs of CC-1065. II. The solution phase parallel synthesis of combinatorial libraries

Tarby, Christine Mary

1996

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Inhibitors of Human Mitotic Kinesin Eg5: Characterization of the 4-Phenyl-tetrahydroisoquinoline Lead Series

ChemInform, 2006-07, Vol.37 (29), p.no-no

2006

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Mild and General Methods for the Palladium-Catalyzed Cyanation of Aryl and Heteroaryl Chlorides

Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors

Modulation of cofilin phosphorylation by inhibition of the Lim family kinases

Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series

Potent antagonists of the CCR2b receptor. Part 3: SAR of the ( R)-3-aminopyrrolidine series

Generalized Dipeptidomimetic Template: Solution Phase Parallel Synthesis of Combinatorial Libraries

Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives

Opportunities for novel therapeutic agents acting at chemokine receptors

Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology

Chemical and Structural Comparison of N-BOC-CBQ and N-BOC-CBI: Identification and Structural Origin of an Unappreciated but Productive Stability of the CC-1065 and Duocarmycin SA Alkylation Subunits

Synthesis, Chemical Properties, and Preliminary Evaluation of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Cyano-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one Alkylation Subunit: Hammett Quantitation of the Magnitude of Electronic Effects on Functional Reactivity

Abstract 5395: Anti-tumor activity of BMS-595, a novel CK2 kinase inhibitor

Abstract 5417: The identification of BMS-595, an orally active imidazo[1,2-b]pyridazine CK2 inhibitor with in vivo anti-tumor activity

Assessing compound binding to the Eg5 motor domain using a thermal shift assay

Design, synthesis and structure–activity relationships of novel biarylamine-based Met kinase inhibitors

A Hammett correlation for CC-1065 and duocarmycin analogs: Magnitude of substituent electronic effects on functional reactivity

A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: A universal and dipeptide mimetic template

Molecular basis for sequence selective DNA alkylation by (+)- and ent-(−)-CC-1065 and related agents: Alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity

Solid-phase synthesis of potential aspartic acid protease inhibitors containing a hydroxyethylamine isostere

Molecular diversity and solid-phase synthesis

Steric and Electronic Effects Controlling the Synthesis of Bridgehead Nitrogen Heterocycles

I. The synthesis and preliminary evaluation of the CCBI alkylation subunit and its extended agents, potent CBI-based analogs of CC-1065. II. The solution phase parallel synthesis of combinatorial libraries

Inhibitors of Human Mitotic Kinesin Eg5: Characterization of the 4-Phenyl-tetrahydroisoquinoline Lead Series

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