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Insulin sensitizers in 2023: lessons learned and new avenues for investigation

Expert opinion on investigational drugs, 2023-09, Vol.32 (9), p.803-811

2023

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Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12992-13012

2020

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Synthesis and bioactivity of readily hydrolysable novel cationic lipids for potential lung delivery application of mRNAs

Chemistry and physics of lipids, 2022-03, Vol.243, p.105178-105178, Article 105178

2022

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Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid as an Excipient in mRNA-Encapsulating Lipid Nanoparticles

Organic process research & development, 2021-06, Vol.25 (6), p.1383-1390

2021

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Insulin sensitizers in 2013: new insights for the development of novel therapeutic agents to treat metabolic diseases

Expert opinion on investigational drugs, 2014-01, Vol.23 (1), p.1-7

2014

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PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development

Bioorganic & medicinal chemistry, 2018-12, Vol.26 (22), p.5870-5884

2018

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Azaindole Hydroxamic Acids are Potent HIV-1 Integrase Inhibitors

Journal of medicinal chemistry, 2009-11, Vol.52 (22), p.7211-7219

2009

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Design and Synthesis of Novel N-Hydroxy-Dihydronaphthyridinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors

Journal of medicinal chemistry, 2011-05, Vol.54 (9), p.3393-3417

2011

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Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1)

Journal of medicinal chemistry, 2011-12, Vol.54 (24), p.8490-8500

2011

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Furan-Terminated N-Acyliminium Ion Initiated Cyclizations in Alkaloid Synthesis

Journal of organic chemistry, 1998-10, Vol.63 (20), p.6914-6928

1998

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Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

Tetrahedron: asymmetry, 2006-08, Vol.17 (14), p.2154-2182

2006

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Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7429-7434

2010

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2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3- b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (12), p.3349-3353

2007

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The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.1994-2000

2010

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Furans in synthesis. 11. Total syntheses of (.+-.)- and (-)-fastigilin C

Journal of the American Chemical Society, 1992-10, Vol.114 (22), p.8349-8362

1992

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Synthesis and Biological Activity of Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid: Discovery of a Novel Aminoguanidinoacetic Acid Antidiabetic Agent

Journal of medicinal chemistry, 2001-04, Vol.44 (8), p.1217-1230

2001

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Furans in synthesis. 8. Formal total syntheses of (.+-.)- and (+)-aphidicolin

Journal of organic chemistry, 1988-10, Vol.53 (21), p.4929-4938

1988

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The development of improved syntheses of PPARγ-sparing, insulin sensitizing thiazolidinedione-ketones

Tetrahedron letters, 2019-08, Vol.60 (33), p.150931, Article 150931

2019

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Synthesis and Biological Activity of Aminoguanidine and Diaminoguanidine Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid

Journal of medicinal chemistry, 2001-04, Vol.44 (8), p.1231-1248

2001

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Furans in synthesis. 3. Furans as terminators in cationic cyclization

Journal of organic chemistry, 1983-12, Vol.48 (24), p.4572-4580

1983

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Stereospecific total synthesis of (.+-.)-warburganal and related compounds

Journal of the American Chemical Society, 1979-07, Vol.101 (15), p.4398-4400

1979

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A simple synthesis of 3-substituted furans. The preparations of dendrolasin, perillene and congeners

Tetrahedron letters, 1982, Vol.23 (31), p.3115-3118

Tanis, Steven P.

1982

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Novel synthesis of CP-734432, an EP4 agonist, using Sharpless asymmetric dihydroxylation

Tetrahedron letters, 2010-03, Vol.51 (11), p.1451-1454

2010

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Pyrroles as terminators in cationic cyclizations. The preparation of 5,6,7,8-tetrahydroindolizidines and 6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]azepines

Journal of organic chemistry, 1987-03, Vol.52 (5), p.819-827

1987

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Nasute termite soldier frontal gland secretions. 2. Structures of trinervitene congeners from Trinervitermes soldiers

Journal of the American Chemical Society, 1976-09, Vol.98 (19), p.6062-6064

1976

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Insulin sensitizers in 2023: lessons learned and new avenues for investigation

Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA

Synthesis and bioactivity of readily hydrolysable novel cationic lipids for potential lung delivery application of mRNAs

Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid as an Excipient in mRNA-Encapsulating Lipid Nanoparticles

Insulin sensitizers in 2013: new insights for the development of novel therapeutic agents to treat metabolic diseases

PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development

Azaindole Hydroxamic Acids are Potent HIV-1 Integrase Inhibitors

Design and Synthesis of Novel N-Hydroxy-Dihydronaphthyridinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors

Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1)

Furan-Terminated N-Acyliminium Ion Initiated Cyclizations in Alkaloid Synthesis

Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK

2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3- b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase

Furans in synthesis. 11. Total syntheses of (.+-.)- and (-)-fastigilin C

Synthesis and Biological Activity of Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid: Discovery of a Novel Aminoguanidinoacetic Acid Antidiabetic Agent

Furans in synthesis. 8. Formal total syntheses of (.+-.)- and (+)-aphidicolin

The development of improved syntheses of PPARγ-sparing, insulin sensitizing thiazolidinedione-ketones

Synthesis and Biological Activity of Aminoguanidine and Diaminoguanidine Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid

Furans in synthesis. 3. Furans as terminators in cationic cyclization

Stereospecific total synthesis of (.+-.)-warburganal and related compounds

A simple synthesis of 3-substituted furans. The preparations of dendrolasin, perillene and congeners

Novel synthesis of CP-734432, an EP4 agonist, using Sharpless asymmetric dihydroxylation

Pyrroles as terminators in cationic cyclizations. The preparation of 5,6,7,8-tetrahydroindolizidines and 6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]azepines

Nasute termite soldier frontal gland secretions. 2. Structures of trinervitene congeners from Trinervitermes soldiers

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