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Rho-associated kinase inhibitors: A novel glaucoma therapy

Progress in retinal and eye research, 2013-11, Vol.37, p.1-12

2013

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Impact of the clinical use of ROCK inhibitor on the pathogenesis and treatment of glaucoma

Japanese journal of ophthalmology, 2018-03, Vol.62 (2), p.109-126

2018

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Phase 2 Randomized Clinical Study of a Rho Kinase Inhibitor, K-115, in Primary Open-Angle Glaucoma and Ocular Hypertension

American journal of ophthalmology, 2013-10, Vol.156 (4), p.731-736.e2

2013

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Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm's canal endothelial cells

Scientific reports, 2016-01, Vol.6 (1), p.19640-19640, Article 19640

2016

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Factors Influencing Aqueous Proinflammatory Cytokines and Growth Factors in Uveitic Glaucoma

PloS one, 2016-01, Vol.11 (1), p.e0147080-e0147080

2016

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YAP/TAZ Are Essential for TGF-β2-Mediated Conjunctival Fibrosis

Investigative ophthalmology & visual science, 2018-06, Vol.59 (7), p.3069-3078

2018

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Suberoylanilide hydroxamic acid (SAHA) inhibits transforming growth factor-beta 2-induced increases in aqueous humor outflow resistance

The Journal of biological chemistry, 2021-09, Vol.297 (3), p.101070-101070, Article 101070

2021

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Intra‐ocular pressure‐lowering effects of a Rho kinase inhibitor, ripasudil (K‐115), over 24 hours in primary open‐angle glaucoma and ocular hypertension: a randomized, open‐label, crossover study

Acta ophthalmologica (Oxford, England), 2015-06, Vol.93 (4), p.e254-e260

2015

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In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (33), p.10515-10520

2015

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RhoA Activation Decreases Phagocytosis of Trabecular Meshwork Cells

Current eye research, 2021-04, Vol.46 (4), p.496-503

2021

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Factors associated with the surgical outcomes of Baerveldt glaucoma implant for open-angle glaucoma, an age-related eye disease

Scientific reports, 2022-01, Vol.12 (1), p.1359-1359, Article 1359

2022

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Safety and efficacy of ripasudil in Japanese patients with glaucoma or ocular hypertension: 12-month interim analysis of ROCK-J, a post-marketing surveillance study

BMC ophthalmology, 2020-07, Vol.20 (1), p.275-275, Article 275

2020

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The effects of ripasudil (K-115), a Rho kinase inhibitor, on activation of human conjunctival fibroblasts

Experimental eye research, 2016-08, Vol.149, p.107-115

2016

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Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation

Stem cell reports, 2018-03, Vol.10 (3), p.1059-1074

2018

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Success Rates of Trabeculotomy for Steroid-Induced Glaucoma: A Comparative, Multicenter, Retrospective Cohort Study

American journal of ophthalmology, 2011-06, Vol.151 (6), p.1047-1056.e1

2011

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Efficacy and safety of SNJ‐1656 in primary open‐angle glaucoma or ocular hypertension

Acta ophthalmologica (Oxford, England), 2015-08, Vol.93 (5), p.e393-e395

2015

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TGF-β-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness

PloS one, 2020-11, Vol.15 (11), p.e0242626-e0242626

2020

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Merlin Regulates Epithelial-to-Mesenchymal Transition of ARPE-19 Cells via TAK1-p38MAPK-Mediated Activation

Investigative ophthalmology & visual science, 2015-04, Vol.56 (4), p.2449-2458

2015

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The effect of Rho-associated protein kinase inhibitor on monkey Schlemm's canal endothelial cells

Investigative ophthalmology & visual science, 2012-05, Vol.53 (6), p.3092-3103

2012

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Vascular Endothelial Growth Factor-A Increases the Aqueous Humor Outflow Facility

PloS one, 2016-09, Vol.11 (9), p.e0161332-e0161332

2016

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Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys

Investigative ophthalmology & visual science, 2007-07, Vol.48 (7), p.3216-3222

2007

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Determinants and Characteristics of Bruch's Membrane Opening and Bruch's Membrane Opening-Minimum Rim Width in a Normal Japanese Population

Investigative ophthalmology & visual science, 2017-08, Vol.58 (10), p.4106-4113

2017

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Live cell imaging of actin dynamics in dexamethasone-treated porcine trabecular meshwork cells

Experimental eye research, 2016-04, Vol.145, p.393-400

2016

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Potential roles of the IL-6 family in conjunctival fibrosis

Experimental eye research, 2021-09, Vol.210, p.108708-108708, Article 108708

2021

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The angiogenic effects of exosomes secreted from retinal pigment epithelial cells on endothelial cells

Biochemistry and biophysics reports, 2020-07, Vol.22, p.100760-100760, Article 100760

2020

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Rho-associated kinase inhibitors: A novel glaucoma therapy

Impact of the clinical use of ROCK inhibitor on the pathogenesis and treatment of glaucoma

Phase 2 Randomized Clinical Study of a Rho Kinase Inhibitor, K-115, in Primary Open-Angle Glaucoma and Ocular Hypertension

Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm's canal endothelial cells

Factors Influencing Aqueous Proinflammatory Cytokines and Growth Factors in Uveitic Glaucoma

YAP/TAZ Are Essential for TGF-β2-Mediated Conjunctival Fibrosis

Suberoylanilide hydroxamic acid (SAHA) inhibits transforming growth factor-beta 2-induced increases in aqueous humor outflow resistance

Intra‐ocular pressure‐lowering effects of a Rho kinase inhibitor, ripasudil (K‐115), over 24 hours in primary open‐angle glaucoma and ocular hypertension: a randomized, open‐label, crossover study

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

RhoA Activation Decreases Phagocytosis of Trabecular Meshwork Cells

Factors associated with the surgical outcomes of Baerveldt glaucoma implant for open-angle glaucoma, an age-related eye disease

Safety and efficacy of ripasudil in Japanese patients with glaucoma or ocular hypertension: 12-month interim analysis of ROCK-J, a post-marketing surveillance study

The effects of ripasudil (K-115), a Rho kinase inhibitor, on activation of human conjunctival fibroblasts

Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation

Success Rates of Trabeculotomy for Steroid-Induced Glaucoma: A Comparative, Multicenter, Retrospective Cohort Study

Efficacy and safety of SNJ‐1656 in primary open‐angle glaucoma or ocular hypertension

TGF-β-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness

Merlin Regulates Epithelial-to-Mesenchymal Transition of ARPE-19 Cells via TAK1-p38MAPK-Mediated Activation

The effect of Rho-associated protein kinase inhibitor on monkey Schlemm's canal endothelial cells

Vascular Endothelial Growth Factor-A Increases the Aqueous Humor Outflow Facility

Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys

Determinants and Characteristics of Bruch's Membrane Opening and Bruch's Membrane Opening-Minimum Rim Width in a Normal Japanese Population

Live cell imaging of actin dynamics in dexamethasone-treated porcine trabecular meshwork cells

Potential roles of the IL-6 family in conjunctival fibrosis

The angiogenic effects of exosomes secreted from retinal pigment epithelial cells on endothelial cells

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