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Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists

Journal of medicinal chemistry, 2011-12, Vol.54 (24), p.8616-8631

2011

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Development and Application of a New General Method for the Asymmetric Synthesis of syn- and anti-1,3-Amino Alcohols

Journal of the American Chemical Society, 2003-09, Vol.125 (37), p.11276-11282

2003

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Asymmetric Synthesis of syn- and anti-1,3-Amino Alcohols

Journal of the American Chemical Society, 2002-06, Vol.124 (23), p.6518-6519

2002

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Asymmetric Synthesis of Protected 1,2-Amino Alcohols Using tert-Butanesulfinyl Aldimines and Ketimines

Journal of organic chemistry, 2001-12, Vol.66 (26), p.8772-8778

2001

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N-tert-Butanesulfinyl Imines: Versatile Intermediates for the Asymmetric Synthesis of Amines

Accounts of chemical research, 2002-11, Vol.35 (11), p.984-995

2002

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Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

ACS medicinal chemistry letters, 2018-12, Vol.9 (12), p.1230-1234

2018

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Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3123-3133

2022

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Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3123-3133

2022

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Asymmetric Synthesis of β-Amino Acid Derivatives Incorporating a Broad Range of Substitution Patterns by Enolate Additions to tert-Butanesulfinyl Imines

Journal of organic chemistry, 2002-11, Vol.67 (22), p.7819-7832

2002

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Spirocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3379-3403

2013

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Design, synthesis, and structure–activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists

Bioorganic & medicinal chemistry, 2013-10, Vol.21 (19), p.5983-5994

2013

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Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists

Bioorganic & medicinal chemistry, 2014-10, Vol.22 (19), p.5428-5445

2014

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Synthesis of Enantiomerically Pure N-tert-Butanesulfinyl Imines (tert-Butanesulfinimines) by the Direct Condensation of tert-Butanesulfinamide with Aldehydes and Ketones

Journal of organic chemistry, 1999-02, Vol.64 (4), p.1278-1284

1999

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The tert-Butanesulfinyl Group: An Ideal Chiral Directing Group and Boc-Surrogate for the Asymmetric Synthesis and Applications of β-Amino Acids

Journal of organic chemistry, 1999-01, Vol.64 (1), p.12-13

1999

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Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache

Bioorganic & medicinal chemistry letters, 2017-01, Vol.27 (2), p.323-328

2017

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Development and Application of a New General Method for the Asymmetric Synthesis of s yn- and a nti-1,3-Amino Alcohols

Journal of the American Chemical Society, 2003-09, Vol.125 (37), p.11276-11282

2003

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Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy

Journal of medicinal chemistry, 2024-08, Vol.67 (16), p.14466-14477

2024

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Asymmetric Synthesis of s yn- and a nti-1,3-Amino Alcohols

Journal of the American Chemical Society, 2002-06, Vol.124 (23), p.6518-6519

2002

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Abstract B30: Structure-based drug discovery of MRTX1257, a selective, covalent KRAS G12C inhibitor with oral activity in animal models of cancer

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.B30-B30

2020

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Asymmetric Synthesis of β-Amino Acid Derivatives Incorporating a Broad Range of Substitution Patterns by Enolate Additions to tert-Butanesulfinyl Imines

ChemInform, 2003-04, Vol.34 (14), p.no-no

2003

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Development and Application of a New General Method for the Asymmetric Synthesis of syn- and anti-1,3-Amino Alcohols

ChemInform, 2004-01, Vol.35 (1), p.no-no

2004

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N-tert-Butanesulfinyl Imines: Versatile Intermediates for the Asymmetric Synthesis of Amines

ChemInform, 2003-02, Vol.34 (7), p.no-no

2003

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Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists

Development and Application of a New General Method for the Asymmetric Synthesis of syn- and anti-1,3-Amino Alcohols

Asymmetric Synthesis of syn- and anti-1,3-Amino Alcohols

Asymmetric Synthesis of Protected 1,2-Amino Alcohols Using tert-Butanesulfinyl Aldimines and Ketimines

N-tert-Butanesulfinyl Imines: Versatile Intermediates for the Asymmetric Synthesis of Amines

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor

Asymmetric Synthesis of β-Amino Acid Derivatives Incorporating a Broad Range of Substitution Patterns by Enolate Additions to tert-Butanesulfinyl Imines

Spirocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

Identification of the Clinical Development Candidate MRTX849 , a Covalent KRAS G12C Inhibitor for the Treatment of Cancer

Design, synthesis, and structure–activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists

Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists

Discovery of 7‑Tetrahydropyran-2-yl Chromans: β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β‑Protein (Aβ) in the Central Nervous System

Synthesis of Enantiomerically Pure N-tert-Butanesulfinyl Imines (tert-Butanesulfinimines) by the Direct Condensation of tert-Butanesulfinamide with Aldehydes and Ketones

The tert-Butanesulfinyl Group: An Ideal Chiral Directing Group and Boc-Surrogate for the Asymmetric Synthesis and Applications of β-Amino Acids

Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache

Development and Application of a New General Method for the Asymmetric Synthesis of s yn- and a nti-1,3-Amino Alcohols

Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy

Asymmetric Synthesis of s yn- and a nti-1,3-Amino Alcohols

Abstract B30: Structure-based drug discovery of MRTX1257, a selective, covalent KRAS G12C inhibitor with oral activity in animal models of cancer

Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer

Asymmetric Synthesis of β-Amino Acid Derivatives Incorporating a Broad Range of Substitution Patterns by Enolate Additions to tert-Butanesulfinyl Imines

Development and Application of a New General Method for the Asymmetric Synthesis of syn- and anti-1,3-Amino Alcohols

N-tert-Butanesulfinyl Imines: Versatile Intermediates for the Asymmetric Synthesis of Amines

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