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Oxidative Cyclization in Natural Product Biosynthesis

Chemical reviews, 2017-04, Vol.117 (8), p.5226-5333

2017

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Identification of the pyranonigrin A biosynthetic gene cluster by genome mining in Penicillium thymicola IBT 5891

AIChE journal, 2018-12, Vol.64 (12), p.4182-4186

2018

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Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products

Organic letters, 2017-10, Vol.19 (19), p.5376-5379

2017

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Biochemical Characterization of a Eukaryotic Decalin-Forming Diels–Alderase

Journal of the American Chemical Society, 2016-12, Vol.138 (49), p.15837-15840

2016

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Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids

Journal of the American Chemical Society, 2018-02, Vol.140 (6), p.2067-2071

2018

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Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast

Journal of the American Chemical Society, 2015-11, Vol.137 (43), p.13724-13727

2015

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Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics

Nature communications, 2021-12, Vol.12 (1), p.7085-7085, Article 7085

2021

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Biosynthesis of Strained Piperazine Alkaloids: Uncovering the Concise Pathway of Herquline A

Journal of the American Chemical Society, 2016-10, Vol.138 (41), p.13529-13532

2016

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Catalysis of Extracellular Deamination by a FAD‐Linked Oxidoreductase after Prodrug Maturation in the Biosynthesis of Saframycin A

Angewandte Chemie International Edition, 2017-07, Vol.56 (31), p.9116-9120

2017

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Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases

Journal of the American Chemical Society, 2017-04, Vol.139 (15), p.5317-5320

2017

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Biosynthesis of Complex Indole Alkaloids: Elucidation of the Concise Pathway of Okaramines

Angewandte Chemie International Edition, 2017-08, Vol.56 (32), p.9478-9482

International ed. in English, 2017

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Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (44), p.11232-11237

2018

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Fungal Highly Reducing Polyketide Synthases Biosynthesize Salicylaldehydes That Are Precursors to Epoxycyclohexenol Natural Products

Journal of the American Chemical Society, 2019-12, Vol.141 (50), p.19538-19541

2019

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Efficient Biosynthesis of Fungal Polyketides Containing the Dioxabicyclo-octane Ring System

Journal of the American Chemical Society, 2015-09, Vol.137 (37), p.11904-11907

2015

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Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43

Journal of natural products (Washington, D.C.), 2013-04, Vol.76 (4), p.685-693

2013

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Genome Mining Discovery of a New Benzazepine Alkaloid Pseudofisnin A from the Marine Fungus Neosartorya pseudofischeri F27-1

Antibiotics (Basel), 2022-10, Vol.11 (10), p.1444

2022

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Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis

Journal of the American Chemical Society, 2014-03, Vol.136 (12), p.4488-4491

2014

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Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi

Journal of the American Chemical Society, 2019-05, Vol.141 (20), p.8198-8206

2019

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Biosynthesis of Tetrahydroisoquinoline Antibiotics

Current topics in medicinal chemistry, 2016-06, Vol.16 (15), p.1717-1726

2016

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Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain

Angewandte Chemie International Edition, 2017-08, Vol.56 (32), p.9556-9560

International ed. in English, 2017

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An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing α-Ketone in Polyketide Starter Unit Biosynthesis

Angewandte Chemie International Edition, 2014-10, Vol.53 (42), p.11315-11319

2014

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Naphthyridinomycin Biosynthesis Revealing the Use of Leader Peptide to Guide Nonribosomal Peptide Assembly

Organic letters, 2013-07, Vol.15 (14), p.3674-3677

2013

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Combinatorial Biosynthesis of Terpenoids through Mixing-and-Matching Sesquiterpene Cyclase and Cytochrome P450 Pairs

Organic letters, 2022-07, Vol.24 (26), p.4783-4787

2022

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Genome Mining of a Fungal Polyketide Synthase–Nonribosomal Peptide Synthetase Hybrid Megasynthetase Pathway to Synthesize a Phytotoxic N‑Acyl Amino Acid

Organic letters, 2024-05, Vol.26 (17), p.3597-3601

2024

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SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis

Nature (London), 2017-09, Vol.549 (7673), p.502-506

2017

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Oxidative Cyclization in Natural Product Biosynthesis

Identification of the pyranonigrin A biosynthetic gene cluster by genome mining in Penicillium thymicola IBT 5891

Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products

Biochemical Characterization of a Eukaryotic Decalin-Forming Diels–Alderase

Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids

Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast

Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics

Biosynthesis of Strained Piperazine Alkaloids: Uncovering the Concise Pathway of Herquline A

Catalysis of Extracellular Deamination by a FAD‐Linked Oxidoreductase after Prodrug Maturation in the Biosynthesis of Saframycin A

Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases

Biosynthesis of Complex Indole Alkaloids: Elucidation of the Concise Pathway of Okaramines

Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis

Fungal Highly Reducing Polyketide Synthases Biosynthesize Salicylaldehydes That Are Precursors to Epoxycyclohexenol Natural Products

Efficient Biosynthesis of Fungal Polyketides Containing the Dioxabicyclo-octane Ring System

Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43

Genome Mining Discovery of a New Benzazepine Alkaloid Pseudofisnin A from the Marine Fungus Neosartorya pseudofischeri F27-1

Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis

Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi

Biosynthesis of Tetrahydroisoquinoline Antibiotics

Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain

An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing α-Ketone in Polyketide Starter Unit Biosynthesis

Naphthyridinomycin Biosynthesis Revealing the Use of Leader Peptide to Guide Nonribosomal Peptide Assembly

Combinatorial Biosynthesis of Terpenoids through Mixing-and-Matching Sesquiterpene Cyclase and Cytochrome P450 Pairs

Genome Mining of a Fungal Polyketide Synthase–Nonribosomal Peptide Synthetase Hybrid Megasynthetase Pathway to Synthesize a Phytotoxic N‑Acyl Amino Acid

SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis

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