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Discovery of MK-8719, a Potent O‑GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

Journal of medicinal chemistry, 2019-11, Vol.62 (22), p.10062-10097

2019

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Use of In Vivo Animal Models to Assess Pharmacokinetic Drug-Drug Interactions

Pharmaceutical research, 2010-09, Vol.27 (9), p.1772-1787

2010

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Effects of fibrates on metabolism of statins in human hepatocytes

Drug metabolism and disposition, 2002-11, Vol.30 (11), p.1280

2002

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Mechanistic studies on metabolic interactions between gemfibrozil and statins

The Journal of pharmacology and experimental therapeutics, 2002-06, Vol.301 (3), p.1042

2002

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ADME of Biologics—What Have We Learned from Small Molecules?

The AAPS journal, 2012-09, Vol.14 (3), p.410-419

2012

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Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs)

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6620-6624

2013

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Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?

Drug metabolism and disposition, 2005-05, Vol.33 (5), p.603

2005

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Theoretical Analysis of Interplay of Therapeutic Protein Drug and Circulating Soluble Target: Temporal Profiles of ‘Free’ and ‘Total’ Drug and Target

Pharmaceutical research, 2011-10, Vol.28 (10), p.2447-2457

2011

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3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (10), p.3129-3133

2010

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Substrate inhibition kinetics for cytochrome P450-catalyzed reactions

Drug metabolism and disposition, 2001-04, Vol.29 (4 Pt 1), p.368

2001

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Drug–Drug Interactions Related to Altered Absorption and Plasma Protein Binding: Theoretical and Regulatory Considerations, and an Industry Perspective

Journal of pharmaceutical sciences, 2015-03, Vol.104 (3), p.916-929

2015

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Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor

The Journal of pharmacology and experimental therapeutics, 2000-05, Vol.293 (2), p.453

2000

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Pyridyl amides as potent inhibitors of T-type calcium channels

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1692-1696

2011

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Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys

Biochemical pharmacology, 2009-09, Vol.78 (6), p.642-647

2009

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Indazole derivatives as novel bradykinin B1 receptor antagonists

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7011-7014

2010

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In vitro and in vivo CYP3A64 induction and inhibition studies in rhesus monkeys: a preclinical approach for CYP3A-mediated drug interaction studies

Drug metabolism and disposition, 2006-09, Vol.34 (9), p.1546

2006

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2-Aminobenzophenones as a Novel Class of Bradykinin B1 Receptor Antagonists

Journal of medicinal chemistry, 2008-07, Vol.51 (13), p.3946-3952

2008

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Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity

Drug metabolism and disposition, 2000-05, Vol.28 (5), p.567

2000

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Rifampin induces the in vitro oxidative metabolism, but not the in vivo clearance of diclofenac in rhesus monkeys

Drug metabolism and disposition, 2006-11, Vol.34 (11), p.1806

2006

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Abstract 1161: EZH2 inhibitor tazemetostat demonstrates activity in preclinical models of Bruton's tyrosine kinase inhibitor-resistant relapsed/refractory mantle cell lymphoma

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1161-1161

2021

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Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes: an impact more than protein binding

Drug metabolism and disposition, 2002-06, Vol.30 (6), p.648

2002

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Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma and Diffuse Large B-Cell Lymphoma

Blood, 2021-11, Vol.138 (Supplement 1), p.1142-1142

2021

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A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity

Bioorganic & medicinal chemistry letters, 2008-01, Vol.18 (2), p.682-687

2008

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Enzyme kinetics of cytochrome P450-mediated reactions

Current drug metabolism, 2001-03, Vol.2 (1), p.17

2001

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P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4

The Journal of pharmacology and experimental therapeutics, 2001-07, Vol.298 (1), p.323

2001

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Discovery of MK-8719, a Potent O‑GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

Use of In Vivo Animal Models to Assess Pharmacokinetic Drug-Drug Interactions

Effects of fibrates on metabolism of statins in human hepatocytes

Mechanistic studies on metabolic interactions between gemfibrozil and statins

ADME of Biologics—What Have We Learned from Small Molecules?

Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs)

Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?

Theoretical Analysis of Interplay of Therapeutic Protein Drug and Circulating Soluble Target: Temporal Profiles of ‘Free’ and ‘Total’ Drug and Target

3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts

Substrate inhibition kinetics for cytochrome P450-catalyzed reactions

Drug–Drug Interactions Related to Altered Absorption and Plasma Protein Binding: Theoretical and Regulatory Considerations, and an Industry Perspective

Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor

Pyridyl amides as potent inhibitors of T-type calcium channels

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys

Indazole derivatives as novel bradykinin B1 receptor antagonists

In vitro and in vivo CYP3A64 induction and inhibition studies in rhesus monkeys: a preclinical approach for CYP3A-mediated drug interaction studies

2-Aminobenzophenones as a Novel Class of Bradykinin B1 Receptor Antagonists

Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity

Rifampin induces the in vitro oxidative metabolism, but not the in vivo clearance of diclofenac in rhesus monkeys

Abstract 1161: EZH2 inhibitor tazemetostat demonstrates activity in preclinical models of Bruton's tyrosine kinase inhibitor-resistant relapsed/refractory mantle cell lymphoma

Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes: an impact more than protein binding

Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma and Diffuse Large B-Cell Lymphoma

A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity

Enzyme kinetics of cytochrome P450-mediated reactions

P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4

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