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Discovery of 5-[5-Fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic Acid (2-Diethylaminoethyl)amide, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

Journal of medicinal chemistry, 2003-03, Vol.46 (7), p.1116-1119

2003

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Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones: A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

Journal of medicinal chemistry, 1998-07, Vol.41 (14), p.2588-2603

1998

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Canada needs a “Health in All Policies” action plan now

Canadian Medical Association journal (CMAJ), 2020-01, Vol.192 (3), p.E61-E67

2020

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WHO Health Promotion Glossary: new terms

Health promotion international, 2006-12, Vol.21 (4), p.340-345

2006

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SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors

Cancer research (Chicago, Ill.), 2000-08, Vol.60 (15), p.4152-4160

2000

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SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types

Cancer research (Chicago, Ill.), 1999, Vol.59 (1), p.99-106

1999

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Novel Potent Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities of 2-Indolinone Derivatives

Journal of medicinal chemistry, 2010-11, Vol.53 (22), p.8140-8149

2010

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Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases

Journal of medicinal chemistry, 1999-12, Vol.42 (25), p.5120-5130

1999

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Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine

Proceedings of the National Academy of Sciences - PNAS, 2006-12, Vol.103 (52), p.19707-19712

2006

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Early-life prevention of non-communicable diseases

The Lancet (British edition), 2013-01, Vol.381 (9860), p.3-4

2013

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A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells

Cancer research (Chicago, Ill.), 2001-08, Vol.61 (16), p.6170-6177

2001

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Policy and partnership for health promotion--addressing the determinants of health

Bulletin of the World Health Organization, 2005-12, Vol.83 (12), p.884-884

2005

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Identification of Substituted 3-[(4,5,6,7-Tetrahydro-1H-indol-2-yl)methylene]- 1,3-dihydroindol-2-ones as Growth Factor Receptor Inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rβ Tyrosine Kinases

Journal of medicinal chemistry, 2000-07, Vol.43 (14), p.2655-2663

2000

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SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization

Oncogene, 2004-01, Vol.23 (4), p.873-882

2004

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Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (22), p.6437-6440

2009

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Synthesis and biological evaluation of C-12′ substituted vinflunine derivatives

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (16), p.4602-4605

2008

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Regiospecific and Stereoselective Syntheses of (±)-Reserpine and (−)-Reserpine

Journal of the American Chemical Society, 2005-11, Vol.127 (46), p.16255-16262

2005

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Schools for health, education and development: a call for action

Health promotion international, 2009-03, Vol.24 (1), p.68-77

2009

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Strengthening the capacity for health promotion in South Africa through international collaboration

Global health promotion, 2010-06, Vol.17 (2_suppl), p.6-16

2010

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Structure-Based design and discovery of novel inhibitors of protein tyrosine phosphatases

Bioorganic & medicinal chemistry, 2003-04, Vol.11 (8), p.1835-1849

2003

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Design and synthesis of aminopropyl tetrahydroindole-based indolin-2-ones as selective and potent inhibitors of Src and Yes tyrosine kinase

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.187-190

2004

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Building capacity for health promotion—a case study from China

Health promotion international, 2005-09, Vol.20 (3), p.285-295

2005

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Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-Dependent kinase 2 inhibitors

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (11), p.1939-1942

2003

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Weekly Dosing With the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor SU9518 Significantly Inhibits Arterial Stenosis

Circulation research, 2001-03, Vol.88 (6), p.630-636

2001

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Discovery of 5-[5-Fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic Acid (2-Diethylaminoethyl)amide, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship

Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones: A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

Canada needs a “Health in All Policies” action plan now

WHO Health Promotion Glossary: new terms

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types

Novel Potent Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities of 2-Indolinone Derivatives

Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases

Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine

Early-life prevention of non-communicable diseases

A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells

Policy and partnership for health promotion--addressing the determinants of health

Identification of Substituted 3-[(4,5,6,7-Tetrahydro-1H-indol-2-yl)methylene]- 1,3-dihydroindol-2-ones as Growth Factor Receptor Inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rβ Tyrosine Kinases

SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization

Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitors

Synthesis and biological evaluation of C-12′ substituted vinflunine derivatives

Regiospecific and Stereoselective Syntheses of (±)-Reserpine and (−)-Reserpine

Schools for health, education and development: a call for action

Strengthening the capacity for health promotion in South Africa through international collaboration

Structure-Based design and discovery of novel inhibitors of protein tyrosine phosphatases

Design and synthesis of aminopropyl tetrahydroindole-based indolin-2-ones as selective and potent inhibitors of Src and Yes tyrosine kinase

Building capacity for health promotion—a case study from China

Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-Dependent kinase 2 inhibitors

Weekly Dosing With the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor SU9518 Significantly Inhibits Arterial Stenosis

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