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Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells

PloS one, 2021-12, Vol.16 (12), p.e0261608-e0261608

2021

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Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice

Frontiers in endocrinology (Lausanne), 2021-02, Vol.12, p.633625-633625

2021

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Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes

Frontiers in endocrinology (Lausanne), 2021-05, Vol.12, p.674704-674704

2021

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Amplifying the antidiabetic actions of glucagon‐like peptide‐1: Potential benefits of new adjunct therapies

Diabetic medicine, 2021-12, Vol.38 (12), p.e14699-n/a

2021

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Pancreatic polypeptide revisited: Potential therapeutic effects in obesity-diabetes

Peptides (New York, N.Y. : 1980), 2023-02, Vol.160, p.170923-170923, Article 170923

2023

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Dapagliflozin exerts positive effects on beta cells, decreases glucagon and does not alter beta- to alpha-cell transdifferentiation in mouse models of diabetes and insulin resistance

Biochemical pharmacology, 2020-07, Vol.177, p.114009, Article 114009

2020

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Liraglutide and sitagliptin counter beta- to alpha-cell transdifferentiation in diabetes

Journal of endocrinology, 2020-04, Vol.245 (1), p.53-64

2020

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Beneficial metabolic effects of recurrent periods of beta‐cell rest and stimulation using stable neuropeptide Y1 and glucagon‐like peptide‐1 receptor agonists

Diabetes, obesity & metabolism, 2022-12, Vol.24 (12), p.2353-2363

2022

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Development and characterisation of a peptidergic N-and C-terminally stabilised mammalian NPY1R agonist which protects against diabetes induction

Biochimica et biophysica acta. General subjects, 2020-05, Vol.1864 (5), p.129543-129543, Article 129543

2020

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Generation and characterisation of C-terminally stabilised PYY molecules with potential in vivo NPYR2 activity

Metabolism, clinical and experimental, 2020-10, Vol.111, p.154339-154339, Article 154339

2020

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Pancreatic islet cell plasticity: Pathogenic or therapeutically exploitable?

Diabetes, obesity & metabolism, 2024-01, Vol.26 (1), p.16-31

2024

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Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation

Diabetes, obesity & metabolism, 2020-12, Vol.22 (12), p.2468-2478

2020

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The glucagon receptor antagonist desHis1Pro4Glu9-glucagon(Lys12PAL) alters alpha-cell turnover and lineage in mice, but does not cause alpha-cell hyperplasia

Molecular and cellular endocrinology, 2023-06, Vol.570, p.111932-111932, Article 111932

2023

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TASK-3, two-pore potassium channels, contribute to circadian rhythms in the electrical properties of the suprachiasmatic nucleus and play a role in driving stable behavioural photic entrainment

Chronobiology international, 2024-06, Vol.41 (6), p.1-816

2024

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Novel enzyme-resistant pancreatic polypeptide analogs evoke pancreatic beta-cell rest, enhance islet cell turnover, and inhibit food intake in mice

BioFactors (Oxford), 2024-04

2024

Volltextzugriff (PDF)

Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic α-cell transdifferentiation

Biochemical pharmacology, 2020-12, Vol.182, p.114216-114216, Article 114216

2020

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Peptide YY (1–36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β‐cell function, growth and survival

Diabetes, obesity & metabolism, 2020-03, Vol.22 (3), p.404-416

2020

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Sustained metabolic benefits of ΔTRTX‐Ac1, a tarantula venom‐derived peptide, when administered together with exenatide in high‐fat fed mice

Diabetes, obesity & metabolism, 2024-01, Vol.26 (1), p.329-338

2024

Volltextzugriff (PDF)

Enzymatically stable analogue of the gut-derived peptide xenin on beta-cell transdifferentiation in high fat fed and insulin-deficient Ins1 Cre/+ ;Rosa26-eYFP mice

Diabetes/metabolism research and reviews, 2021-03, Vol.37 (3), p.e3384

2021

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Enzymatically stable analogue of the gut‐derived peptide xenin on beta‐cell transdifferentiation in high fat fed and insulin‐deficient Ins1Cre/+;Rosa26‐eYFP mice

Diabetes/metabolism research and reviews, 2021-03, Vol.37 (3), p.e3384-n/a

2021

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Exendin‐4(Lys27PAL)/gastrin/xenin‐8‐Gln: A novel acylated GLP‐1/gastrin/xenin hybrid peptide that improves metabolic status in obese‐diabetic (ob/ob) mice

Diabetes/metabolism research and reviews, 2019-03, Vol.35 (3), p.e3106-n/a

2019

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The glucagon receptor antagonist desHis 1 Pro 4 Glu 9 -glucagon(Lys 12 PAL) alters alpha-cell turnover and lineage in mice, but does not cause alpha-cell hyperplasia

Molecular and cellular endocrinology, 2023-06, Vol.570, p.111932

2023

Volltextzugriff (PDF)

Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice

Peptides (New York, N.Y. : 1980), 2020-03, Vol.125, p.170205-170205, Article 170205

2020

Volltextzugriff (PDF)

Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic Glu CreERT2 ;ROSA26-eYFP mice

Peptides (New York, N.Y. : 1980), 2020-03, Vol.125, p.170205

2020

Volltextzugriff (PDF)

A recombinant modified vaccinia ankara vaccine encoding Epstein-Barr Virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer

Clinical cancer research, 2014-10, Vol.20 (19), p.5009-5022

2014

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Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells

Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice

Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes

Amplifying the antidiabetic actions of glucagon‐like peptide‐1: Potential benefits of new adjunct therapies

Pancreatic polypeptide revisited: Potential therapeutic effects in obesity-diabetes

Dapagliflozin exerts positive effects on beta cells, decreases glucagon and does not alter beta- to alpha-cell transdifferentiation in mouse models of diabetes and insulin resistance

Liraglutide and sitagliptin counter beta- to alpha-cell transdifferentiation in diabetes

Beneficial metabolic effects of recurrent periods of beta‐cell rest and stimulation using stable neuropeptide Y1 and glucagon‐like peptide‐1 receptor agonists

Development and characterisation of a peptidergic N-and C-terminally stabilised mammalian NPY1R agonist which protects against diabetes induction

Generation and characterisation of C-terminally stabilised PYY molecules with potential in vivo NPYR2 activity

Pancreatic islet cell plasticity: Pathogenic or therapeutically exploitable?

Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation

The glucagon receptor antagonist desHis1Pro4Glu9-glucagon(Lys12PAL) alters alpha-cell turnover and lineage in mice, but does not cause alpha-cell hyperplasia

TASK-3, two-pore potassium channels, contribute to circadian rhythms in the electrical properties of the suprachiasmatic nucleus and play a role in driving stable behavioural photic entrainment

Novel enzyme-resistant pancreatic polypeptide analogs evoke pancreatic beta-cell rest, enhance islet cell turnover, and inhibit food intake in mice

Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic α-cell transdifferentiation

Peptide YY (1–36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β‐cell function, growth and survival

Sustained metabolic benefits of ΔTRTX‐Ac1, a tarantula venom‐derived peptide, when administered together with exenatide in high‐fat fed mice

Enzymatically stable analogue of the gut-derived peptide xenin on beta-cell transdifferentiation in high fat fed and insulin-deficient Ins1 Cre/+ ;Rosa26-eYFP mice

Enzymatically stable analogue of the gut‐derived peptide xenin on beta‐cell transdifferentiation in high fat fed and insulin‐deficient Ins1Cre/+;Rosa26‐eYFP mice

Exendin‐4(Lys27PAL)/gastrin/xenin‐8‐Gln: A novel acylated GLP‐1/gastrin/xenin hybrid peptide that improves metabolic status in obese‐diabetic (ob/ob) mice

The glucagon receptor antagonist desHis 1 Pro 4 Glu 9 -glucagon(Lys 12 PAL) alters alpha-cell turnover and lineage in mice, but does not cause alpha-cell hyperplasia

Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice

Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic Glu CreERT2 ;ROSA26-eYFP mice

A recombinant modified vaccinia ankara vaccine encoding Epstein-Barr Virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer

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