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Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides

Angewandte Chemie (International ed.), 2015-12, Vol.54 (51), p.15410-15413

International ed. in English, 2015

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Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer

Angewandte Chemie (International ed.), 2017-01, Vol.56 (2), p.524-529

International ed. in English, 2017

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The Multifaceted Roles of Molecular Dynamics Simulations in Drug Discovery

Current pharmaceutical design, 2016-01, Vol.22 (23), p.3585

2016

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Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells

Beilstein journal of organic chemistry, 2016-07, Vol.12 (1), p.1428-1433

2016

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Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells

Nature communications, 2021-05, Vol.12 (1), p.3133-3133, Article 3133

2021

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HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes

Nature communications, 2024-06, Vol.15 (1), p.4288-21, Article 4288

2024

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A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling

Nature chemistry, 2013-10, Vol.5 (10), p.861

2013

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Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription

Nature communications, 2023-10, Vol.14 (1), p.6464-6464, Article 6464

2023

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The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Nature communications, 2024-02, Vol.15 (1), p.1385-1385, Article 1385

2024

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Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides

Chemical communications (Cambridge, England), 2019-07, Vol.55 (55), p.7914-7917

2019

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The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein–Protein Interactions

Journal of chemical theory and computation, 2015-07, Vol.11 (7), p.3199-3210

2015

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The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations

Journal of chemical information and modeling, 2014-07, Vol.54 (7), p.1821-1827

2014

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Anatomy of Mdm2 and Mdm4 in evolution

Journal of molecular cell biology, 2017-02, Vol.9 (1), p.3

2017

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Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties

Molecules (Basel, Switzerland), 2019-06, Vol.24 (12), p.2292

2019

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Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

Angewandte Chemie (International ed.), 2012-10, Vol.51 (40), p.10078-10081

2012

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Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles

Chemical science (Cambridge), 2019-07, Vol.1 (26), p.6457-6466

2019

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An Efficient, Short Stimulus PANC-1 Cancer Cell Ablation and Electrothermal Therapy Driven by Hydrophobic Interactions

Pharmaceutics, 2022-12, Vol.15 (1), p.106

2022

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A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds

Organic & biomolecular chemistry, 2015-04, Vol.13 (15), p.4570-4580

2015

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Inhibiting S100B(ββ) for Activating Wild-Type p53: Design of Stapled Peptides

ACS omega, 2019-03, Vol.4 (3), p.5335-5344

2019

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Stapled peptide design: principles and roles of computation

Drug discovery today, 2016-10, Vol.21 (10), p.1642-1653

2016

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Straightforward Incorporation of Multiple Ligand Types into Molecular Dynamics Simulations for Efficient Binding Site Detection and Characterization

Journal of chemical theory and computation, 2020-10, Vol.16 (10), p.6633-6644

2020

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Dissecting the geometric and hydrophobic constraints of stapled peptides

Proteins, structure, function, and bioinformatics, 2024-01

2024

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Shape complementarity processes for ultrashort-burst sensitive M13–PEG–WS 2 -powered MCF-7 cancer cell sensors

Nanoscale, 2023-10, Vol.15 (41), p.16658-16668

2023

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Shape complementarity processes for ultrashort-burst sensitive M13-PEG-WS-powered MCF-7 cancer cell sensors

Nanoscale, 2023-10, Vol.15 (41), p.16658-16668

2023

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Accelerated Ligand-Mapping Molecular Dynamics Simulations for the Detection of Recalcitrant Cryptic Pockets and Occluded Binding Sites

Journal of chemical theory and computation, 2022-03, Vol.18 (3), p.1969-1981

2022

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Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides

Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer

The Multifaceted Roles of Molecular Dynamics Simulations in Drug Discovery

Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells

Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells

HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes

A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling

Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides

The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein–Protein Interactions

The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations

Anatomy of Mdm2 and Mdm4 in evolution

Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties

Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles

An Efficient, Short Stimulus PANC-1 Cancer Cell Ablation and Electrothermal Therapy Driven by Hydrophobic Interactions

A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds

Inhibiting S100B(ββ) for Activating Wild-Type p53: Design of Stapled Peptides

Stapled peptide design: principles and roles of computation

Straightforward Incorporation of Multiple Ligand Types into Molecular Dynamics Simulations for Efficient Binding Site Detection and Characterization

Dissecting the geometric and hydrophobic constraints of stapled peptides

Shape complementarity processes for ultrashort-burst sensitive M13–PEG–WS 2 -powered MCF-7 cancer cell sensors

Shape complementarity processes for ultrashort-burst sensitive M13-PEG-WS-powered MCF-7 cancer cell sensors

Accelerated Ligand-Mapping Molecular Dynamics Simulations for the Detection of Recalcitrant Cryptic Pockets and Occluded Binding Sites

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