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Animal Models for the Development of Cancer Immunotherapy

Tan, Seng-Lai

1, 2022

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Combined Inhibition of Tumor Necrosis Factor α and Interleukin‐17 As a Therapeutic Opportunity in Rheumatoid Arthritis: Development and Characterization of a Novel Bispecific Antibody

Arthritis & rheumatology (Hoboken, N.J.), 2015-01, Vol.67 (1), p.51-62

2015

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TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

Molecular cell, 2011-02, Vol.41 (4), p.458-470

2011

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Tocilizumab, a humanized anti-IL-6R antibody, as an emerging therapeutic option for rheumatoid arthritis: molecular and cellular mechanistic insights

International reviews of immunology, 2015-05, Vol.34 (3), p.265-279

2015

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Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication?

Virology (New York, N.Y.), 2007-07, Vol.364 (1), p.1-9

2007

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Hepatitis C therapeutics: current status and emerging strategies

Nature reviews. Drug discovery, 2002-11, Vol.1 (11), p.867-881

2002

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Small-molecule inhibitors of spleen tyrosine kinase as therapeutic agents for immune disorders: will promise meet expectations?

Future medicinal chemistry, 2014-10, Vol.6 (16), p.1811-1827

2014

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Translational Immunology: Mechanisms and Pharmacologic Approaches

Tan, Seng-Lai

1, 2015

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1131 Anti-CLEC2D-TLR9 agonist conjugate binds to and internalizes CLEC2D on myeloid cells, plasmacytoid DCs and B cells leading to robust TLR pathway activation and inflammatory cytokine production

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1243-A1243

2023

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Discovery of small-molecule inhibitors of HCV NS3-4A protease as potential therapeutic agents against HCV infection

Current medicinal chemistry, 2005, Vol.12 (20), p.2317-2342

2005

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Translational Control of Viral Gene Expression in Eukaryotes

Microbiology and Molecular Biology Reviews, 2000-06, Vol.64 (2), p.239-280

2000

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874 Development of BCA101, a bifunctional antibody capable of simultaneously disabling EGFR and TGFβ signaling, as novel single-agent immunotherapy

Journal for immunotherapy of cancer, 2021-11, Vol.9 (Suppl 2), p.A915-A916

2021

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Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation

Molecular and Cellular Biology, 1998-09, Vol.18 (9), p.5208-5218

1998

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Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase

Journal of Virology, 2002-09, Vol.76 (18), p.9207-9217

2002

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Systems biology and the host response to viral infection

Nature biotechnology, 2007-12, Vol.25 (12), p.1383-1389

2007

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Targeting the SYK―BTK axis for the treatment of immunological and hematological disorders Recent progress and therapeutic perspectives

Pharmacology & therapeutics (Oxford), 2013-05, Vol.138 (2), p.294-309

2013

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Emerging and diverse roles of protein kinase C in immune cell signalling

Biochemical journal, 2003-12, Vol.376 (Pt 3), p.545-552

2003

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Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model

Arthritis research & therapy, 2006-01, Vol.8 (1), p.R28-R28

2006

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When Translation Meets Metabolism: Multiple Links to Diabetes

Endocrine reviews, 2003-02, Vol.24 (1), p.91-101

2003

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NS5A, a Nonstructural Protein of Hepatitis C Virus, Binds Growth Factor Receptor-Bound Protein 2 Adaptor Protein in a Src Homology 3 Domain/Ligand-Dependent Manner and Perturbs Mitogenic Signaling

Proceedings of the National Academy of Sciences - PNAS, 1999-05, Vol.96 (10), p.5533-5538

1999

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Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties

The Journal of biological chemistry, 2015-06, Vol.290 (26), p.16330-16342

2015

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Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: A potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial joints

Immunology letters, 2013-02, Vol.150 (1), p.97-104

2013

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Data for the crystal structure of APRIL–BAFF–BAFF heterotrimer

Data in brief, 2016-03, Vol.6, p.438-444

2016

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Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain

Molecular and Cellular Biology, 1998-12, Vol.18 (12), p.7304-7316

1998

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Animal Models for the Development of Cancer Immunotherapy

Combined Inhibition of Tumor Necrosis Factor α and Interleukin‐17 As a Therapeutic Opportunity in Rheumatoid Arthritis: Development and Characterization of a Novel Bispecific Antibody

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

Tocilizumab, a humanized anti-IL-6R antibody, as an emerging therapeutic option for rheumatoid arthritis: molecular and cellular mechanistic insights

Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication?

Hepatitis C therapeutics: current status and emerging strategies

Small-molecule inhibitors of spleen tyrosine kinase as therapeutic agents for immune disorders: will promise meet expectations?

Translational Immunology: Mechanisms and Pharmacologic Approaches

1131 Anti-CLEC2D-TLR9 agonist conjugate binds to and internalizes CLEC2D on myeloid cells, plasmacytoid DCs and B cells leading to robust TLR pathway activation and inflammatory cytokine production

Discovery of small-molecule inhibitors of HCV NS3-4A protease as potential therapeutic agents against HCV infection

Translational Control of Viral Gene Expression in Eukaryotes

874 Development of BCA101, a bifunctional antibody capable of simultaneously disabling EGFR and TGFβ signaling, as novel single-agent immunotherapy

Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation

Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase

Systems biology and the host response to viral infection

BCA101 Is a Tumor-Targeted Bifunctional Fusion Antibody That Simultaneously Inhibits EGFR and TGFβ Signaling to Durably Suppress Tumor Growth

Targeting the SYK―BTK axis for the treatment of immunological and hematological disorders Recent progress and therapeutic perspectives

Emerging and diverse roles of protein kinase C in immune cell signalling

Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model

When Translation Meets Metabolism: Multiple Links to Diabetes

NS5A, a Nonstructural Protein of Hepatitis C Virus, Binds Growth Factor Receptor-Bound Protein 2 Adaptor Protein in a Src Homology 3 Domain/Ligand-Dependent Manner and Perturbs Mitogenic Signaling

Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties

Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: A potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial joints

Data for the crystal structure of APRIL–BAFF–BAFF heterotrimer

Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain

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