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Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action

PloS one, 2018-04, Vol.13 (4), p.e0195909-e0195909

2018

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Characterization of multivalent complexes formed in the presence of more than one conventional antibody to terminal complement component C5

PloS one, 2023-04, Vol.18 (4), p.e0284502

2023

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Genetic Variants in C5 and Poor Response to Eculizumab

The New England journal of medicine, 2014-02, Vol.370 (7), p.632-639

2014

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Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration

mAbs, 2024-12, Vol.16 (1), p.2415060

2024

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Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9

Molecular cancer therapeutics, 2012-02, Vol.11 (2), p.340-349

2012

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Complement system activation contributes to the ependymal damage induced by microbial neuraminidase

Journal of neuroinflammation, 2016-05, Vol.13 (1), p.115-115, Article 115

2016

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Eculizumab can bind to protein complexes containing C5b

Molecular immunology, 2018-10, Vol.102, p.168-168

2018

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A TPO Receptor Agonist, ALXN4100TPO, Mitigates Radiation-Induced Lethality and Stimulates Hematopoiesis in CD2F1 Mice

Radiation research, 2011-06, Vol.175 (6), p.746-758

2011

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IGG SUBCLASS VARIATION OF A MONOCLONAL ANTIBODY BINDING TO HUMAN FC-GAMMA RECEPTORS

American journal of biochemistry and biotechnology, 2013-06, Vol.9 (3), p.206-218

2013

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Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration

Molecular immunology, 2024-01, Vol.165, p.29-41

2024

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Characterization of multivalent complexes formed in the presence of more than one conventional antibody to terminal complement component C5

PloS one, 2023-01, Vol.18 (4), p.e0284502

2023

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Characterization of Placental Bikunin, a Novel Human Serine Protease Inhibitor

The Journal of biological chemistry, 1997-05, Vol.272 (18), p.12209-12214

1997

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Enzymatic peptidyl .alpha.-amidation proceeds through formation of an .alpha.-hydroxyglycine intermediate

Journal of the American Chemical Society, 1989-03, Vol.111 (5), p.1933-1934

1989

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Identification and Cloning of Human Placental Bikunin, a Novel Serine Protease Inhibitor Containing Two Kunitz Domains

The Journal of biological chemistry, 1997-05, Vol.272 (18), p.12202-12208

1997

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First in Human Single-Ascending Dose Study: Safety, Biomarker, Pharmacokinetics and Exposure-Response Relationships of ALXN1210, a Humanized Monoclonal Antibody to C5, with Marked Half-Life Extension and Potential for Significantly Longer Dosing Intervals

Blood, 2015-12, Vol.126 (23), p.4777-4777

2015

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Design and preclinical characterization of ALXN1210: A next generation anti-C5 monoclonal antibody with improved pharmacokinetics and duration of action

Immunobiology (1979), 2016-10, Vol.221 (10), p.1158-1158

2016

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A Rare Genetic Polymorphism in C5 Confers Poor Response to the Anti-C5 Monoclonal Antibody Eculizumab by Nine Japanese Patients with PNH

Blood, 2012-11, Vol.120 (21), p.3197-3197

2012

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A Rare Genetic Polymorphism In C5 Confers Poor Response To The Anti-C5 Monoclonal Antibody Eculizumab In 11 Japanese Patients With PNH

Blood, 2013-11, Vol.122 (21), p.3709-3709

2013

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Abstract 2577: In vitro and in vivo efficacy of the anti-MN immunoconjugate BAY 79-4620, MN-IC, in MN (CAIX) expressing preclinical tumor models

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.2577-2577

2010

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Role of aspartic proteases in disseminated Candida albicans infection in mice

Infection and Immunity, 1997-02, Vol.65 (2), p.551-556

1997

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Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)

Biochemical journal, 1982-04, Vol.203 (1), p.161-168

1982

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17β‐Hydroxysteroid Dehydrogenases in Human Bone Cells

Journal of bone and mineral research, 1998-10, Vol.13 (10), p.1539-1546

1998

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Reduction kinetics of purified rat liver cytochrome P-450. Evidence for a sequential reaction mechanism dependent on the hemoprotein spin state

Biochemistry (Easton), 1984-09, Vol.23 (20), p.4526-4533

1984

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Kinetics of cytochrome P-450 reduction: evidence for faster reduction of the high-spin ferric state

Biochemistry (Easton), 1985-09, Vol.24 (19), p.5130-5136

1985

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Inhibition of cathepsin L-like cysteine proteases by cytotoxic T-lymphocyte antigen-2 beta

The Journal of biological chemistry, 1994-10, Vol.269 (40), p.25172-25177

1994

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Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action

Characterization of multivalent complexes formed in the presence of more than one conventional antibody to terminal complement component C5

Genetic Variants in C5 and Poor Response to Eculizumab

Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration

Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9

Complement system activation contributes to the ependymal damage induced by microbial neuraminidase

Eculizumab can bind to protein complexes containing C5b

A TPO Receptor Agonist, ALXN4100TPO, Mitigates Radiation-Induced Lethality and Stimulates Hematopoiesis in CD2F1 Mice

IGG SUBCLASS VARIATION OF A MONOCLONAL ANTIBODY BINDING TO HUMAN FC-GAMMA RECEPTORS

Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration

Characterization of multivalent complexes formed in the presence of more than one conventional antibody to terminal complement component C5

Characterization of Placental Bikunin, a Novel Human Serine Protease Inhibitor

Enzymatic peptidyl .alpha.-amidation proceeds through formation of an .alpha.-hydroxyglycine intermediate

Identification and Cloning of Human Placental Bikunin, a Novel Serine Protease Inhibitor Containing Two Kunitz Domains

First in Human Single-Ascending Dose Study: Safety, Biomarker, Pharmacokinetics and Exposure-Response Relationships of ALXN1210, a Humanized Monoclonal Antibody to C5, with Marked Half-Life Extension and Potential for Significantly Longer Dosing Intervals

Design and preclinical characterization of ALXN1210: A next generation anti-C5 monoclonal antibody with improved pharmacokinetics and duration of action

A Rare Genetic Polymorphism in C5 Confers Poor Response to the Anti-C5 Monoclonal Antibody Eculizumab by Nine Japanese Patients with PNH

A Rare Genetic Polymorphism In C5 Confers Poor Response To The Anti-C5 Monoclonal Antibody Eculizumab In 11 Japanese Patients With PNH

Abstract 2577: In vitro and in vivo efficacy of the anti-MN immunoconjugate BAY 79-4620, MN-IC, in MN (CAIX) expressing preclinical tumor models

Role of aspartic proteases in disseminated Candida albicans infection in mice

Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)

17β‐Hydroxysteroid Dehydrogenases in Human Bone Cells

Reduction kinetics of purified rat liver cytochrome P-450. Evidence for a sequential reaction mechanism dependent on the hemoprotein spin state

Kinetics of cytochrome P-450 reduction: evidence for faster reduction of the high-spin ferric state

Inhibition of cathepsin L-like cysteine proteases by cytotoxic T-lymphocyte antigen-2 beta

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