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Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer's disease model

Scientific reports, 2021-02, Vol.11 (1), p.2879-17, Article 2879

2021

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Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

Frontiers in pharmacology, 2019-08, Vol.10, p.840-840

2019

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Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

Nature (London), 1996-04, Vol.380 (6576), p.723-726

1996

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Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease

The Journal of neuroscience, 2023-06, Vol.43 (24), p.4541-4557

2023

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MEK1/2 activity modulates TREM2 cell surface recruitment

The Journal of biological chemistry, 2021-01, Vol.296, p.100218-100218, Article 100218

2021

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Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease

Alzheimer's & dementia, 2024-01, Vol.20 (1), p.74-90

2024

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Involvement of caspase 3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli

Oncogene, 1999-08, Vol.18 (31), p.4401-4408

1999

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Caspase-Dependent Regulation and Subcellular Redistribution of the Transcriptional Modulator YY1 during Apoptosis

Molecular and Cellular Biology, 2005-05, Vol.25 (9), p.3704-3714

2005

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Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

The Journal of biological chemistry, 1997-12, Vol.272 (49), p.31138-31148

1997

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Sequence-Specific DNA Binding by a Short Peptide Dimer

Science (American Association for the Advancement of Science), 1990-08, Vol.249 (4970), p.769-771

1990

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Substrate Specificities of Caspase Family Proteases

The Journal of biological chemistry, 1997-04, Vol.272 (15), p.9677-9682

1997

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Current in vitro kinase assay technologies: the quest for a universal format

Current drug discovery technologies, 2008-03, Vol.5 (1), p.59-69

2008

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Nitric Oxide Prevents Tumor Necrosis Factor α–Induced Rat Hepatocyte Apoptosis by the Interruption of Mitochondrial Apoptotic Signaling Through S-Nitrosylation of Caspase-8

Hepatology (Baltimore, Md.), 2000-10, Vol.32 (4), p.770-778

2000

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Caspases as Targets for Anti-Inflammatory and Anti-Apoptotic Drug Discovery

Journal of medicinal chemistry, 2000-09, Vol.43 (18), p.3351-3371

2000

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Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis

Archives of biochemistry and biophysics, 1998-08, Vol.356 (2), p.187-196

1998

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Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) : Caspase-8 is required for TRAIL-induced apoptosis

Cancer research (Chicago, Ill.), 2001-02, Vol.61 (3), p.1138-1143

2001

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2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (1), p.330-333

2010

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Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

BMC structural biology, 2012-09, Vol.12 (1), p.22-22

2012

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Minimum length of a sequence-specific DNA binding peptide

Biochemistry (Easton), 1992-08, Vol.31 (30), p.6871-6875

1992

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Minimum significant ratio of selectivity ratios (MSRSR) and confidence in ratio of selectivity ratios (CRSR): quantitative measures for selectivity ratios obtained by screening assays

Journal of biomolecular screening, 2012-08, Vol.17 (7), p.857-867

2012

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2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.334-337

2010

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Activation of a CrmA-insensitive, p35-sensitive Pathway in Ionizing Radiation-induced Apoptosis

The Journal of biological chemistry, 1997-01, Vol.272 (3), p.1965-1969

1997

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Role for Caspase-Mediated Cleavage of Rad51 in Induction of Apoptosis by DNA Damage

Molecular and Cellular Biology, 1999-04, Vol.19 (4), p.2986-2997

1999

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Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study

BMC structural biology, 2009-03, Vol.9 (1), p.16-16

2009

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The APOEε4 allele exacerbates the transcriptomic responses to Aβ plaques and neurofibrillary tangles in Alzheimer’s disease

Alzheimer's & dementia, 2023-06, Vol.19 (S1), p.n/a

2023

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Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer's disease model

Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease

MEK1/2 activity modulates TREM2 cell surface recruitment

Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease

Involvement of caspase 3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli

Caspase-Dependent Regulation and Subcellular Redistribution of the Transcriptional Modulator YY1 during Apoptosis

Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

Sequence-Specific DNA Binding by a Short Peptide Dimer

Substrate Specificities of Caspase Family Proteases

Current in vitro kinase assay technologies: the quest for a universal format

Nitric Oxide Prevents Tumor Necrosis Factor α–Induced Rat Hepatocyte Apoptosis by the Interruption of Mitochondrial Apoptotic Signaling Through S-Nitrosylation of Caspase-8

Caspases as Targets for Anti-Inflammatory and Anti-Apoptotic Drug Discovery

Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis

Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) : Caspase-8 is required for TRAIL-induced apoptosis

2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

Minimum length of a sequence-specific DNA binding peptide

Minimum significant ratio of selectivity ratios (MSRSR) and confidence in ratio of selectivity ratios (CRSR): quantitative measures for selectivity ratios obtained by screening assays

2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization

Activation of a CrmA-insensitive, p35-sensitive Pathway in Ionizing Radiation-induced Apoptosis

Role for Caspase-Mediated Cleavage of Rad51 in Induction of Apoptosis by DNA Damage

Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study

The APOEε4 allele exacerbates the transcriptomic responses to Aβ plaques and neurofibrillary tangles in Alzheimer’s disease

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