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Spectral Accuracy of Molecular Ions in an LTQ/Orbitrap Mass Spectrometer and Implications for Elemental Composition Determination

Journal of the American Society for Mass Spectrometry, 2009-11, Vol.20 (11), p.2058-2069

2009

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Rapid metabolite identification with sub parts-per-million mass accuracy from biological matrices by direct infusion nanoelectrospray ionization after clean-up on a ZipTip and LTQ/Orbitrap mass spectrometry

Rapid communications in mass spectrometry, 2008-10, Vol.22 (19), p.3015-3026

2008

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Strategies for dealing with metabolite elucidation in drug discovery and development

Drug Discovery Today, 2004-04, Vol.9 (7), p.317-327

2004

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Metabolism, excretion, and pharmacokinetics of [14C]tigecycline, a first-in-class glycylcycline antibiotic, after intravenous infusion to healthy male subjects

Drug metabolism and disposition, 2007-09, Vol.35 (9), p.1543

2007

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Characterization of HKI-272 covalent binding to human serum albumin

Drug metabolism and disposition, 2010-07, Vol.38 (7), p.1083

2010

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Metabolite identification in rat brain microdialysates by direct infusion nanoelectrospray ionization after desalting on a ZipTip and LTQ/Orbitrap mass spectrometry

Rapid communications in mass spectrometry, 2009-12, Vol.23 (24), p.4003-4012

2009

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Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved

Drug metabolism and disposition, 2004-06, Vol.32 (6), p.639

2004

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Liquid chromatography/mass spectrometry determination of endogenous plasma acetyl and palmitoyl carnitines as potential biomarkers of β-oxidation in mice

Rapid communications in mass spectrometry, 2008-11, Vol.22 (21), p.3434-3442

2008

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A Novel Approach for Predicting Acyl Glucuronide Reactivity via Schiff Base Formation: Development of Rapidly Formed Peptide Adducts for LC/MS/MS Measurements

Chemical research in toxicology, 2004-09, Vol.17 (9), p.1206-1216

2004

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Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry

Drug metabolism and disposition, 2007-06, Vol.35 (6), p.908

2007

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Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

Chemical research in toxicology, 2009-02, Vol.22 (2), p.299-310

2009

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Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase

Drug metabolism and disposition, 2004-04, Vol.32 (4), p.442

2004

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Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction

Biochemical pharmacology, 2001-07, Vol.62 (2), p.191-198

2001

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Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards

Chemical research in toxicology, 2009-02, Vol.22 (2), p.311-322

2009

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Alternate Strategies to Obtain Mass Balance without the Use of Radiolabeled Compounds: Application of Quantitative Fluorine (19F) Nuclear Magnetic Resonance (NMR) Spectroscopy in Metabolism Studies

Chemical research in toxicology, 2012-03, Vol.25 (3), p.572-583

2012

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Drug interactions: concerns and current approaches

IDrugs : the investigational drugs journal, 2007-01, Vol.10 (1), p.47

2007

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Mechanism study of N-dephenylation mediated through a N-para-hydroxy metabolite

Current drug discovery technologies, 2006-06, Vol.3 (2), p.101

2006

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Application of quantitative NMR in pharmacological evaluation of biologically generated metabolites: implications in drug discovery

Drug metabolism and disposition, 2011-01, Vol.39 (1), p.106

2011

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Alternate Strategies to Obtain Mass Balance without the Use of Radiolabeled Compounds: Application of Quantitative Fluorine ( super(19)F) Nuclear Magnetic Resonance (NMR) Spectroscopy in Metabolism Studies

Chemical research in toxicology, 2012-03, Vol.25 (3), p.572-583-572-583

2012

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Metabolism and Distribution of [2,3-14C]Acrolein in Lactating Goats

Journal of agricultural and food chemistry, 2001-03, Vol.49 (3), p.1630-1638

2001

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Metabolism of intravenous methylnaltrexone in mice, rats, dogs, and humans

Drug metabolism and disposition, 2010-04, Vol.38 (4), p.606

2010

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Integrating chemical and biological remediation of atrazine and s-triazine-containing pesticide wastes

Environmental toxicology and chemistry, 1996-08, Vol.15 (8), p.1255-1262

1996

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High Sensitivity High Performance Liquid Chromatography Electrospray Tandem Mass Spectrometry Determination of Terfenadine in Human Plasma

Journal of liquid chromatography & related technologies, 1996-09, Vol.19 (16), p.2669-2679

1996

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Metabolism and Distribution of [2,3-14C]Acrolein in Sprague-Dawley Rats

Toxicological sciences, 1998-06, Vol.43 (2), p.110-120

1998

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The impact of recent innovations in the use of liquid chromatography-mass spectrometry in support of drug metabolism studies: are we all the way there yet?

Current opinion in drug discovery & development, 2006-01, Vol.9 (1), p.61

2006

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Spectral Accuracy of Molecular Ions in an LTQ/Orbitrap Mass Spectrometer and Implications for Elemental Composition Determination

Rapid metabolite identification with sub parts-per-million mass accuracy from biological matrices by direct infusion nanoelectrospray ionization after clean-up on a ZipTip and LTQ/Orbitrap mass spectrometry

Strategies for dealing with metabolite elucidation in drug discovery and development

Metabolism, excretion, and pharmacokinetics of [14C]tigecycline, a first-in-class glycylcycline antibiotic, after intravenous infusion to healthy male subjects

Characterization of HKI-272 covalent binding to human serum albumin

Metabolite identification in rat brain microdialysates by direct infusion nanoelectrospray ionization after desalting on a ZipTip and LTQ/Orbitrap mass spectrometry

Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved

Liquid chromatography/mass spectrometry determination of endogenous plasma acetyl and palmitoyl carnitines as potential biomarkers of β-oxidation in mice

A Novel Approach for Predicting Acyl Glucuronide Reactivity via Schiff Base Formation: Development of Rapidly Formed Peptide Adducts for LC/MS/MS Measurements

Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry

Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase

Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction

Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards

Alternate Strategies to Obtain Mass Balance without the Use of Radiolabeled Compounds: Application of Quantitative Fluorine (19F) Nuclear Magnetic Resonance (NMR) Spectroscopy in Metabolism Studies

Drug interactions: concerns and current approaches

Mechanism study of N-dephenylation mediated through a N-para-hydroxy metabolite

Application of quantitative NMR in pharmacological evaluation of biologically generated metabolites: implications in drug discovery

Alternate Strategies to Obtain Mass Balance without the Use of Radiolabeled Compounds: Application of Quantitative Fluorine ( super(19)F) Nuclear Magnetic Resonance (NMR) Spectroscopy in Metabolism Studies

Metabolism and Distribution of [2,3-14C]Acrolein in Lactating Goats

Metabolism of intravenous methylnaltrexone in mice, rats, dogs, and humans

Integrating chemical and biological remediation of atrazine and s-triazine-containing pesticide wastes

High Sensitivity High Performance Liquid Chromatography Electrospray Tandem Mass Spectrometry Determination of Terfenadine in Human Plasma

Metabolism and Distribution of [2,3-14C]Acrolein in Sprague-Dawley Rats

The impact of recent innovations in the use of liquid chromatography-mass spectrometry in support of drug metabolism studies: are we all the way there yet?

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