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Abstract 4436: A novel antibody-enabled dual precision targeted protein stabilization (TPS2) that augments anti-tumor immune response by targeting CBL-B inhibitor to exhausted T cells while blocking checkpoint molecule, PD-1

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.4436-4436

2023

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Abstract 2118: Development of RNAscope multiplex-based assay for exploratory pharmacodynamic biomarkers assessment in breast cancer patients from Phase I clinical trial of ORM-5029, a potent GSPT1 degrader

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2118-2118

2023

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ORM-6151: A First-in-Class, Anti-CD33 Antibody-Enabled GSPT1 Degrader for AML

Blood, 2022-11, Vol.140 (Supplement 1), p.3061-3062

2022

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Abstract 3933: ORM-5029: A first-in-class targeted protein degradation therapy using antibody neodegrader conjugate (AnDC) for HER2-expressing breast cancer

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3933-3933

2022

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Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity

Bioorganic & medicinal chemistry letters, 2017-12, Vol.27 (23), p.5310-5321

2017

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Progress against Escherichia coli with the Oxazolidinone Class of Antibacterials: Test Case for a General Approach To Improving Whole-Cell Gram-Negative Activity

ACS infectious diseases, 2016-06, Vol.2 (6), p.405-426

2016

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Progress Towards Addressing Gram Negative Bacterial Resistance

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (31), p.11236-11236

2014

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Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (31), p.E3187-E3195

2014

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Synthesis of Rigidified eIF4E/eIF4G Inhibitor‑1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction

Journal of medicinal chemistry, 2014-06, Vol.57 (12), p.5094-5111

2014

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Structure–activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein–protein interaction inhibitors

European journal of medicinal chemistry, 2014-04, Vol.77, p.361-377

2014

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Structureeactivity relationship study of 4EGI-1, small molecule eIF4E/eIF4G proteineprotein interaction inhibitors

European journal of medicinal chemistry, 2014-04, Vol.77 (22 April 2014), p.361-377

2014

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Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase

Journal of medicinal chemistry, 2013-12, Vol.56 (23), p.9457-9470

2013

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Insight into Acid Driven Formation of Spiro-[oxindole]xanthenes from Isatin and Phenols

Current organic chemistry, 2012-07, Vol.16 (13), p.1581-1593

2012

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New reduction pathways for ctc-[PtCl2(CH3CO2)2(NH3)(Am)] anticancer prodrugs

Chemical communications (Cambridge, England), 2010-03, Vol.46 (11), p.1842-1844

2010

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Semiautomated synthesis of a novel [ 18F] amine fluorocyanoborane for PET imaging studies. Radiosynthesis and in vivo characterization in rats

Applied radiation and isotopes, 2007-02, Vol.65 (2), p.204-208

2007

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Pharmacologically Active Boranes

ChemInform, 2006-12, Vol.37 (52), p.no-no

2006

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Synthesis and Antifungal Activity of a Novel Series of Alkyldimethylamine Cyanoboranes and Their Derivatives

Journal of medicinal chemistry, 2006-08, Vol.49 (16), p.4879-4885

2006

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Pharmacologically active boranes

Pure and applied chemistry, 2006-07, Vol.78 (7), p.1425-1453

2006

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Preparation of Novel Fluoro Derivatives of Amine Cyanoboranes and Amine Carboxyborane Esters

Organometallics, 2005-11, Vol.24 (23), p.5776-5779

2005

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Diborane (4) derivatives via coupling of amine monobromocyanoboranes: Study of the bromination of amine cyanoborane and molecular structures of the amine dibromocyanoboranes

Journal of organometallic chemistry, 2005-09, Vol.690 (18), p.4150-4158

2005

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Trimethylaminedibromopropoxycarbonylborane

Applied organometallic chemistry, 2005-03, Vol.19 (3), p.391-392

2005

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Dimethyl-2-phenylethan-2-olamine cyanoborane

Applied organometallic chemistry, 2005-03, Vol.19 (3), p.386-387

2005

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Crystallographic report: Trimethylaminedibromopropoxycarbonylborane

Applied organometallic chemistry, 2005-03, Vol.19 (3), p.391-392

2005

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Crystallographic report: Dimethyl-2-phenylethan-2-olamine cyanoborane

Applied organometallic chemistry, 2005-03, Vol.19 (3), p.386-387

2005

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Abstract 4436: A novel antibody-enabled dual precision targeted protein stabilization (TPS2) that augments anti-tumor immune response by targeting CBL-B inhibitor to exhausted T cells while blocking checkpoint molecule, PD-1

Abstract 2118: Development of RNAscope multiplex-based assay for exploratory pharmacodynamic biomarkers assessment in breast cancer patients from Phase I clinical trial of ORM-5029, a potent GSPT1 degrader

ORM-6151: A First-in-Class, Anti-CD33 Antibody-Enabled GSPT1 Degrader for AML

Abstract 3933: ORM-5029: A first-in-class targeted protein degradation therapy using antibody neodegrader conjugate (AnDC) for HER2-expressing breast cancer

Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity

Progress against Escherichia coli with the Oxazolidinone Class of Antibacterials: Test Case for a General Approach To Improving Whole-Cell Gram-Negative Activity

Progress Towards Addressing Gram Negative Bacterial Resistance

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

Synthesis of Rigidified eIF4E/eIF4G Inhibitor‑1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction

Structure–activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein–protein interaction inhibitors

Structureeactivity relationship study of 4EGI-1, small molecule eIF4E/eIF4G proteineprotein interaction inhibitors

Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase

Insight into Acid Driven Formation of Spiro-[oxindole]xanthenes from Isatin and Phenols

New reduction pathways for ctc-[PtCl2(CH3CO2)2(NH3)(Am)] anticancer prodrugs

Semiautomated synthesis of a novel [ 18F] amine fluorocyanoborane for PET imaging studies. Radiosynthesis and in vivo characterization in rats

Pharmacologically Active Boranes

Synthesis and Antifungal Activity of a Novel Series of Alkyldimethylamine Cyanoboranes and Their Derivatives

Pharmacologically active boranes

Preparation of Novel Fluoro Derivatives of Amine Cyanoboranes and Amine Carboxyborane Esters

Diborane (4) derivatives via coupling of amine monobromocyanoboranes: Study of the bromination of amine cyanoborane and molecular structures of the amine dibromocyanoboranes

Trimethylaminedibromopropoxycarbonylborane

Dimethyl-2-phenylethan-2-olamine cyanoborane

Crystallographic report: Trimethylaminedibromopropoxycarbonylborane

Crystallographic report: Dimethyl-2-phenylethan-2-olamine cyanoborane

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