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Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human

Molecular pharmaceutics, 2020-11, Vol.17 (11), p.4114-4124

2020

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Catabolites identification and quantification of antisense oligonucleotides by liquid chromatography - high resolution mass spectrometry (LC-HRMS)

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100949, Article 100949

2024

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Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine

Drug metabolism and disposition, 2020-07, Vol.48 (7), p.528-536

2020

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Characterization of the Ontogeny of Hepatic UDP‐Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes

Journal of clinical pharmacology, 2019-09, Vol.59 (S1), p.S42-S55

2019

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Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate

Drug metabolism and disposition, 2020-02, Vol.48 (2), p.86-92

2020

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The Absolute Bioavailability and Absorption, Metabolism, and Excretion of Ipatasertib, a Potent and Highly Selective Protein Kinase B (Akt) Inhibitor

Drug metabolism and disposition, 2023-10, Vol.51 (10), p.1332-1341

2023

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Characterization of Hepatic UDP-Glucuronosyltransferase Enzyme Abundance-Activity Correlations and Population Variability Using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes

Drug metabolism and disposition, 2021-09, Vol.49 (9), p.760-769

2021

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Novel Homodimer Metabolites of GDC-0994 via Cytochrome P450-Catalyzed Radical Coupling

Drug metabolism and disposition, 2020-06, Vol.48 (6), p.521-527

2020

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Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4

Drug metabolism and disposition, 2017-06, Vol.45 (6), p.581-585

2017

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Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation

Journal of clinical pharmacology, 2020-06, Vol.60 (6), p.722-733

2020

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Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug–Drug Interactions

Molecular pharmaceutics, 2017-05, Vol.14 (5), p.1754-1759

2017

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Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases

Journal of medicinal chemistry, 2024-04, Vol.67 (7), p.5758-5782

2024

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Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species

Analytical biochemistry, 2018-09, Vol.556, p.85-90

2018

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Bioactivation and reactivity research advances – 2022 year in review

Drug metabolism reviews, 2023-11, Vol.55 (4), p.267-300

2023

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Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans

Drug metabolism and disposition, 2016-01, Vol.44 (1), p.28-39

2016

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Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450

Drug metabolism and disposition, 2017-05, Vol.45 (5), p.430-440

2017

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CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339

Drug metabolism and disposition, 2017-10, Vol.45 (10), p.1084-1092

2017

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P214 - Investigating the impact of enzyme correlations on inter-individual variability in pharmacokinetics and drug-drug interactions

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S87-S87

2020

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Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450-Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor

Drug metabolism and disposition, 2015-12, Vol.43 (12), p.1929-1933

2015

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A categorical ₂ action on some moduli spaces of sheaves

Transactions of the American Mathematical Society, 2022-12, Vol.375 (12), p.8969-9005

2022

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A categorical \mathfrak{sl}_2 action on some moduli spaces of sheaves

Transactions of the American Mathematical Society, 2022-12, Vol.375 (12), p.8969

2022

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Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study

Drug metabolism letters, 2019, Vol.13 (1), p.37-44

2019

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A10 - Characterization of differential tissue abundance of major non-cyp enzymes in human

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S21-S21

2020

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Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST)

Drug metabolism letters, 2017-11, Vol.11 (1)

2017

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Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human

Catabolites identification and quantification of antisense oligonucleotides by liquid chromatography - high resolution mass spectrometry (LC-HRMS)

Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine

Characterization of the Ontogeny of Hepatic UDP‐Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes

Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate

The Absolute Bioavailability and Absorption, Metabolism, and Excretion of Ipatasertib, a Potent and Highly Selective Protein Kinase B (Akt) Inhibitor

Characterization of Hepatic UDP-Glucuronosyltransferase Enzyme Abundance-Activity Correlations and Population Variability Using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes

Novel Homodimer Metabolites of GDC-0994 via Cytochrome P450-Catalyzed Radical Coupling

Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4

Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation

Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug–Drug Interactions

Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases

Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species

Bioactivation and reactivity research advances – 2022 year in review

Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans

Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450

CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339

P214 - Investigating the impact of enzyme correlations on inter-individual variability in pharmacokinetics and drug-drug interactions

Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450-Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor

A categorical ₂ action on some moduli spaces of sheaves

A categorical \mathfrak{sl}_2 action on some moduli spaces of sheaves

Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study

A10 - Characterization of differential tissue abundance of major non-cyp enzymes in human

Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST)

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