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Improvement of Pulmonary Function by Oral Treatment with a VLA-4 Antagonist in a Mouse Asthmatic Model

Journal of Pharmacological Sciences, 2013/02/20, Vol.121(2), pp.172-175

2013

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Metabolism and disposition of [14C]tivantinib after oral administration to humans, dogs and rats

Xenobiotica, 2014-11, Vol.44 (11), p.996-1008

2014

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Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist

Journal of medicinal chemistry, 2009-12, Vol.52 (24), p.7974-7992

2009

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Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist

Bioorganic & medicinal chemistry, 2012-02, Vol.20 (3), p.1201-1212

2012

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Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity

Biochemical and biophysical research communications, 2024-06, Vol.715, p.149995, Article 149995

2024

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Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models

European journal of pharmacology, 2023-12, Vol.961, p.176184-176184, Article 176184

2023

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4-(Pyrrolidinyl)methoxybenzoic Acid Derivatives as a Potent, Orally Active VLA-4 Antagonist

Chemical and Pharmaceutical Bulletin, 2006, Vol.54(11), pp.1515-1529

2006

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DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model

Oncotarget, 2019-08, Vol.10 (50), p.5152-5167

2019

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A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

Bioorganic & medicinal chemistry, 2013-01, Vol.21 (1), p.42-61

2013

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Improvement of Pulmonary Function by Oral Treatment with a VLA-4 Antagonist in a Mouse Asthmatic Model

Journal of Pharmacological Sciences, 2013-02, Vol.121 (2), p.172-175

2013

Volltextzugriff (PDF)

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazo l yl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmeth o x y]cyclohexanecarboxylic acid

Bioorganic & medicinal chemistry, 2013-01, Vol.21 (1), p.42-61

2013

Volltextzugriff (PDF)

Discovery of ans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4s)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist

Journal of medicinal chemistry, 2009, Vol.52 (24), p.7974-7992

2009

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Complexes of Europium(III) with Nitrate and Chloride Ions in 4 m H(ClO4) and Na(ClO4)

Bulletin of the Chemical Society of Japan, 1967-02, Vol.40 (2), p.251-254

1967

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Renal Cell Carcinoma and Hepatocellular Carcinoma in a Patient with Wilson's Disease

Internal Medicine, 2024/04/01, Vol.63(7), pp.963-968

2024

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Clinical usefulness of phase angle as an indicator of muscle wasting and malnutrition in inpatients with cardiovascular diseases

Asia Pacific Journal of Clinical Nutrition, 2023-09, Vol.32 (3), p.297-307

2023

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Simple method for predicting muscle volume loss using geriatric nutritional risk index in hepatocellular carcinoma patients

Journal of cachexia, sarcopenia and muscle, 2023-08, Vol.14 (4), p.1906-1911

2023

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Factors associated with self-perceived treatment-resistance in bipolar disorder

Medicine (Baltimore), 2024-01, Vol.103 (1), p.e36217-e36217

2024

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Efficacy of chemotherapy in elderly patients with unresectable pancreatic cancer: a multicenter review of 895 patients

BMC gastroenterology, 2017-05, Vol.17 (1), p.66-66, Article 66

2017

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Changes in characteristics of gastroenterology center inpatients in Japan because of rapidly aging society

Journal of gastroenterology and hepatology, 2024-08, Vol.39 (8), p.1528-1534

2024

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Mismatch repair systems might facilitate the chromosomal recombination induced by N-nitrosodimethylamine, but not by N-nitrosodiethylamine, in Drosophila

Mutagenesis, 2020-03, Vol.35 (2), p.197-206

2020

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Renal Cell Carcinoma and Hepatocellular Carcinoma in a Patient with Wilson's Disease: A Case Report

Internal Medicine, 2023, pp.2056-23

2023

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Improvement of Pulmonary Function by Oral Treatment with a VLA-4 Antagonist in a Mouse Asthmatic Model

Metabolism and disposition of [14C]tivantinib after oral administration to humans, dogs and rats

Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist

Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist

Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity

Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models

4-(Pyrrolidinyl)methoxybenzoic Acid Derivatives as a Potent, Orally Active VLA-4 Antagonist

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

Improvement of Pulmonary Function by Oral Treatment with a VLA-4 Antagonist in a Mouse Asthmatic Model

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazo l yl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmeth o x y]cyclohexanecarboxylic acid

Discovery of ans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4s)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist

Complexes of Europium(III) with Nitrate and Chloride Ions in 4 m H(ClO4) and Na(ClO4)

Renal Cell Carcinoma and Hepatocellular Carcinoma in a Patient with Wilson's Disease

Clinical usefulness of phase angle as an indicator of muscle wasting and malnutrition in inpatients with cardiovascular diseases

A Genome Epidemiological Study of SARS-CoV-2 Introduction into Japan

Simple method for predicting muscle volume loss using geriatric nutritional risk index in hepatocellular carcinoma patients

Factors associated with self-perceived treatment-resistance in bipolar disorder

Efficacy of chemotherapy in elderly patients with unresectable pancreatic cancer: a multicenter review of 895 patients

Comparison of Surgical Resection and Percutaneous Ultrasonographic Guided Radiofrequency Ablation for Initial Recurrence of Hepatocellular Carcinoma in Early Stage following Curative Treatment

Clinical Usefulness of Surgical Resection Including the Complementary Use of Radiofrequency Ablation for Intermediate-Stage Hepatocellular Carcinoma

Changes in characteristics of gastroenterology center inpatients in Japan because of rapidly aging society

Mismatch repair systems might facilitate the chromosomal recombination induced by N-nitrosodimethylamine, but not by N-nitrosodiethylamine, in Drosophila

Simple Scoring System for Esophagogastric Varices Prediction in Hepatocellular Carcinoma Patients without Liver Stiffness Evaluation

Renal Cell Carcinoma and Hepatocellular Carcinoma in a Patient with Wilson's Disease: A Case Report

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