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Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

Science (American Association for the Advancement of Science), 2015-06, Vol.348 (6240), p.1223-1223

2015

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Activation of thromboxane A2 receptor (TP) increases the expression of monocyte chemoattractant protein -1 (MCP-1)/chemokine (C-C motif) ligand 2 (CCL2) and recruits macrophages to promote invasion of lung cancer cells

PloS one, 2013, Vol.8 (1), p.e54073

2013

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Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD -/- ) mice due to requirement for embryo 15-HPGD activity

Scientific reports, 2019-11, Vol.9 (1), p.17612-9, Article 17612

2019

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Thromboxane A2 receptor-mediated release of matrix metalloproteinase-1 (MMP-1) induces expression of monocyte chemoattractant protein-1 (MCP-1) by activation of protease-activated receptor 2 (PAR2) in A549 human lung adenocarcinoma cells

Molecular carcinogenesis, 2014-08, Vol.53 (8), p.659-666

2014

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15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer

Cancer research (Chicago, Ill.), 2006-08, Vol.66 (15), p.7818-7823

2006

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Computational Redesign of Human Butyrylcholinesterase for Anticocaine Medication

Proceedings of the National Academy of Sciences - PNAS, 2005-11, Vol.102 (46), p.16656-16661

2005

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Prostaglandin catabolic enzymes as tumor suppressors

Cancer and metastasis reviews, 2011-12, Vol.30 (3-4), p.409-417

Tai, Hsin-Hsiung

2011

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15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Colorectal Cancer

The Journal of biological chemistry, 2005-02, Vol.280 (5), p.3217-3223

2005

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15-Hydroxyprostaglandin Dehydrogenase, a COX-2 Oncogene Antagonist, Is a TGF-β-Induced Suppressor of Human Gastrointestinal Cancers

Proceedings of the National Academy of Sciences - PNAS, 2004-12, Vol.101 (50), p.17468-17473

2004

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15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors

Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (23), p.9409-9413

2009

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15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Gastric Cancer

Clinical cancer research, 2009-07, Vol.15 (14), p.4572-4580

2009

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NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer

Carcinogenesis (New York), 2005-01, Vol.26 (1), p.65-72

2005

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Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells

Carcinogenesis (New York), 2006-11, Vol.27 (11), p.2170-2179

2006

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Preterm Birth without Progesterone Withdrawal in 15-Hydroxyprostaglandin Dehydrogenase Hypomorphic Mice

Molecular endocrinology (Baltimore, Md.), 2008-01, Vol.22 (1), p.105-112

2008

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Computational Design of a Human Butyrylcholinesterase Mutant for Accelerating Cocaine Hydrolysis Based on the Transition-State Simulation

Angewandte Chemie (International ed.), 2006-01, Vol.45 (4), p.653-657

2006

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Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer

Cancer research (Chicago, Ill.), 2007-06, Vol.67 (12), p.5587-5593

2007

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Most Efficient Cocaine Hydrolase Designed by Virtual Screening of Transition States

Journal of the American Chemical Society, 2008-09, Vol.130 (36), p.12148-12155

2008

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Activation of extracellular signal-regulated kinase by 12-hydroxyheptadecatrienoic acid in prostate cancer PC3 cells

Archives of biochemistry and biophysics, 2007-11, Vol.467 (1), p.20-30

2007

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Metabolism of Prostaglandin Glycerol Esters and Prostaglandin Ethanolamides in Vitro and in Vivo

The Journal of biological chemistry, 2001-10, Vol.276 (40), p.36993-36998

2001

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Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine

Biochemical journal, 2013-08, Vol.453 (3), p.447-454

2013

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Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine

Molecular pharmacology, 2011-02, Vol.79 (2), p.290-297

2011

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Synthesis and Biological Evaluation of Novel Thiazolidinedione Analogues as 15-Hydroxyprostaglandin Dehydrogenase Inhibitors

Journal of medicinal chemistry, 2011-07, Vol.54 (14), p.5260-5264

2011

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Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs)

Prostaglandins & other lipid mediators, 2011-11, Vol.96 (1), p.37-40

2011

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Novel human mPGES-1 inhibitors identified through structure-based virtual screening

Bioorganic & medicinal chemistry, 2011-10, Vol.19 (20), p.6077-6086

2011

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Free-Energy Perturbation Simulation on Transition States and Redesign of Butyrylcholinesterase

Biophysical journal, 2009-03, Vol.96 (5), p.1931-1938

2009

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Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

Activation of thromboxane A2 receptor (TP) increases the expression of monocyte chemoattractant protein -1 (MCP-1)/chemokine (C-C motif) ligand 2 (CCL2) and recruits macrophages to promote invasion of lung cancer cells

Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD -/- ) mice due to requirement for embryo 15-HPGD activity

Thromboxane A2 receptor-mediated release of matrix metalloproteinase-1 (MMP-1) induces expression of monocyte chemoattractant protein-1 (MCP-1) by activation of protease-activated receptor 2 (PAR2) in A549 human lung adenocarcinoma cells

15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer

Computational Redesign of Human Butyrylcholinesterase for Anticocaine Medication

Prostaglandin catabolic enzymes as tumor suppressors

15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Colorectal Cancer

15-Hydroxyprostaglandin Dehydrogenase, a COX-2 Oncogene Antagonist, Is a TGF-β-Induced Suppressor of Human Gastrointestinal Cancers

15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors

15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Gastric Cancer

NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer

Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells

Preterm Birth without Progesterone Withdrawal in 15-Hydroxyprostaglandin Dehydrogenase Hypomorphic Mice

Computational Design of a Human Butyrylcholinesterase Mutant for Accelerating Cocaine Hydrolysis Based on the Transition-State Simulation

Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer

Most Efficient Cocaine Hydrolase Designed by Virtual Screening of Transition States

Activation of extracellular signal-regulated kinase by 12-hydroxyheptadecatrienoic acid in prostate cancer PC3 cells

Metabolism of Prostaglandin Glycerol Esters and Prostaglandin Ethanolamides in Vitro and in Vivo

Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine

Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine

Synthesis and Biological Evaluation of Novel Thiazolidinedione Analogues as 15-Hydroxyprostaglandin Dehydrogenase Inhibitors

Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs)

Novel human mPGES-1 inhibitors identified through structure-based virtual screening

Free-Energy Perturbation Simulation on Transition States and Redesign of Butyrylcholinesterase

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