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Prediction of Human Pharmacokinetics Profile of Monoclonal Antibody Using hFcRn Transgenic Mouse Model

Biological and Pharmaceutical Bulletin, 2021/03/01, Vol.44(3), pp.389-395

2021

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In vivo imaging with two-photon microscopy to assess the tumor-selective binding of an anti-CD137 switch antibody

Scientific reports, 2022-03, Vol.12 (1), p.4907-4907, Article 4907

2022

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Electrophysiological Characterization of Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells

Journal of Pharmacological Sciences, 2011, Vol.117(3), pp.149-159

2011

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Conduction and contraction properties of human iPS cell-derived cardiomyocytes: analysis by motion field imaging compared with the guinea-pig isolated heart model

The Journal of Toxicological Sciences, 2018, Vol.43(8), pp.493-506

2018

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Cardiac safety assessment with motion field imaging analysis of human iPS cell-derived cardiomyocytes is improved by an integrated evaluation with cardiac ion channel profiling

The Journal of Toxicological Sciences, 2019, Vol.44(12), pp.859-870

2019

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Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4 + T cell interleukin-2 secretion

mAbs, 2023-12, Vol.15 (1), p.2253570-2253570

2023

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Involvement of the Autonomic Nervous System in Diurnal Variation of Corrected QT Intervals in Common Marmosets

Journal of Pharmacological Sciences, 2013/02/20, Vol.121(2), pp.131-137

2013

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Is an in vitro whole blood cytokine assay useful to detect the potential risk of severe infusion reaction of monoclonal antibody pharmaceuticals?

The Journal of Toxicological Sciences, 2016/08/01, Vol.41(4), pp.523-531

2016

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In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity

Journal of immunotoxicology, 2019-01, Vol.16 (1), p.125-132

2019

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Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties

ACS medicinal chemistry letters, 2013-11, Vol.4 (11), p.1059-1063

2013

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Estimating the clinical risk of hypertension from VEGF signal inhibitors by a non-clinical approach using telemetered rats

The Journal of Toxicological Sciences, 2014/04/01, Vol.39(2), pp.237-242

2014

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Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning

ACS medicinal chemistry letters, 2014-04, Vol.5 (4), p.309-314

2014

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Prediction of drug-induced QT interval prolongation in telemetered common marmosets

The Journal of Toxicological Sciences, 2008/08/01, Vol.33(3), pp.315-325

2008

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Accurate detection of drug-induced delayed ventricular repolarization with a suitable correction formula in Langendorff guinea pig heart

The Journal of Toxicological Sciences, 2010/10/01, Vol.35(5), pp.687-698

2010

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Cardiovascular safety profile of MA-2029, a novel motilin receptor antagonist

The Journal of Toxicological Sciences, 2008/12/01, Vol.33(5), pp.631-639

2008

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QT-RR RELATIONSHIPS AND SUITABLE QT CORRECTION FORMULAS FOR HALOTHANE-ANESTHETIZED DOGS

The Journal of Toxicological Sciences, 2006, Vol.31(4), pp.381-390

2006

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Application of probabilistic analysis for precisely correcting the QT interval for heart rate in telemetered common marmosets

Journal of pharmacological and toxicological methods, 2010-05, Vol.61 (3), p.264-270

2010

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Sensitivity of common marmosets to detect drug-induced QT interval prolongation: Moxifloxacin case study

Journal of pharmacological and toxicological methods, 2010-05, Vol.61 (3), p.271-276

2010

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PRECLINICAL ELECTROPHYSIOLOGY ASSAYS OF MITEMCINAL (GM-611), A NOVEL PROKINETIC AGENT DERIVED FROM ERYTHROMYCIN

The Journal of Toxicological Sciences, 2007, Vol.32(3), pp.217-230

2007

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Different players generate positive responses in two in vitro cytokine assay formats with aqueous and immobilized TGN1412 analog

Biochemical and biophysical research communications, 2018-07, Vol.502 (1), p.91-97

2018

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HEMODYNAMIC AND ELECTROPHYSIOLOGICAL EFFECTS OF MITEMCINAL (GM-611), A NOVEL PROKINETIC AGENT DERIVED FROM ERYTHROMYCIN IN A HALOTHANE-ANESTHETIZED CANINE MODEL

The Journal of Toxicological Sciences, 2007, Vol.32(3), pp.231-239

2007

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Studies of in vivo drug-induced QT interval prolongation in early-stage drug development

The Japanese Journal of Veterinary Research, 2010, Vol.58 (1), p.30-31

Mitsuyasu Tabo

2010

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The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (23), p.6223-6227

2013

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Monophasic action potential in anaesthetized guinea pigs as a biomarker for prediction of liability for drug-induced delayed ventricular repolarization

Journal of pharmacological and toxicological methods, 2007, Vol.55 (3), p.271-278

2007

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Monophasic action potential in anaesthetized guinea pigs as a biomarker for prediction of liability for drug-induced delayed ventricular repolarization

Journal of pharmacological and toxicological methods, 2007-05, Vol.55 (3), p.254

2007

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Prediction of Human Pharmacokinetics Profile of Monoclonal Antibody Using hFcRn Transgenic Mouse Model

In vivo imaging with two-photon microscopy to assess the tumor-selective binding of an anti-CD137 switch antibody

Electrophysiological Characterization of Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells

Conduction and contraction properties of human iPS cell-derived cardiomyocytes: analysis by motion field imaging compared with the guinea-pig isolated heart model

Cardiac safety assessment with motion field imaging analysis of human iPS cell-derived cardiomyocytes is improved by an integrated evaluation with cardiac ion channel profiling

Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4 + T cell interleukin-2 secretion

Involvement of the Autonomic Nervous System in Diurnal Variation of Corrected QT Intervals in Common Marmosets

Is an in vitro whole blood cytokine assay useful to detect the potential risk of severe infusion reaction of monoclonal antibody pharmaceuticals?

In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity

Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties

Estimating the clinical risk of hypertension from VEGF signal inhibitors by a non-clinical approach using telemetered rats

Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning

Prediction of drug-induced QT interval prolongation in telemetered common marmosets

Accurate detection of drug-induced delayed ventricular repolarization with a suitable correction formula in Langendorff guinea pig heart

Cardiovascular safety profile of MA-2029, a novel motilin receptor antagonist

QT-RR RELATIONSHIPS AND SUITABLE QT CORRECTION FORMULAS FOR HALOTHANE-ANESTHETIZED DOGS

Application of probabilistic analysis for precisely correcting the QT interval for heart rate in telemetered common marmosets

Sensitivity of common marmosets to detect drug-induced QT interval prolongation: Moxifloxacin case study

PRECLINICAL ELECTROPHYSIOLOGY ASSAYS OF MITEMCINAL (GM-611), A NOVEL PROKINETIC AGENT DERIVED FROM ERYTHROMYCIN

Different players generate positive responses in two in vitro cytokine assay formats with aqueous and immobilized TGN1412 analog

HEMODYNAMIC AND ELECTROPHYSIOLOGICAL EFFECTS OF MITEMCINAL (GM-611), A NOVEL PROKINETIC AGENT DERIVED FROM ERYTHROMYCIN IN A HALOTHANE-ANESTHETIZED CANINE MODEL

Studies of in vivo drug-induced QT interval prolongation in early-stage drug development

The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors

Monophasic action potential in anaesthetized guinea pigs as a biomarker for prediction of liability for drug-induced delayed ventricular repolarization

Monophasic action potential in anaesthetized guinea pigs as a biomarker for prediction of liability for drug-induced delayed ventricular repolarization

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