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FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity

Cell reports (Cambridge), 2021-04, Vol.35 (1), p.108935, Article 108935

2021

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An Isoproteic Cocoa Butter-Based Ketogenic Diet Fails to Improve Glucose Homeostasis and Promote Weight Loss in Obese Mice

American journal of physiology: endocrinology and metabolism, 2022-07, Vol.323 (1), p.E8-E20

2022

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Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation

Cardiovascular diabetology, 2023-03, Vol.22 (1), p.73-73, Article 73

2023

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The anti-anginal ranolazine does not confer beneficial actions against hepatic steatosis in male mice subjected to high-fat diet and streptozotocin-induced type 2 diabetes

Canadian journal of physiology and pharmacology, 2022-05, Vol.100 (5), p.393-401

2022

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The antianginal ranolazine fails to improve glycaemia in obese liver‐specific pyruvate dehydrogenase deficient male mice

Basic & clinical pharmacology & toxicology, 2023-08, Vol.133 (2), p.194-201

2023

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Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy

Cell reports (Cambridge), 2024-08, Vol.43 (8), p.114573, Article 114573

2024

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FOXM1 Inhibitors as Potential Diagnostic Agents: First Generation of a PET Probe Targeting FOXM1 To Detect Triple‐Negative Breast Cancer in vitro and in vivo

ChemMedChem, 2021-12, Vol.16 (24), p.3720-3729

2021

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Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy

Journal of the American Heart Association, 2024-04, Vol.13 (7), p.e032697-e032697

2024

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Structure-Activity Relationship of N -Phenylthieno[2,3- b ]pyridine-2-carboxamide Derivatives Designed as Forkhead Box M1 Inhibitors: The Effect of Electron-Withdrawing and Donating Substituents on the Phenyl Ring

Pharmaceuticals (Basel, Switzerland), 2022-02, Vol.15 (3), p.283

2022

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SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes

Journal of the American Heart Association, 2021-12, Vol.10 (23), p.e020451-e020451

2021

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Myocardial disturbances of intermediary metabolism in Barth syndrome

Frontiers in cardiovascular medicine, 2022-08, Vol.9, p.981972-981972

2022

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The therapeutic potential of ketones in cardiometabolic disease: impact on heart and skeletal muscle

American Journal of Physiology: Cell Physiology, 2024-02, Vol.326 (2), p.C551-C566

2024

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Stimulating myocardial pyruvate dehydrogenase activity fails to alleviate cardiac abnormalities in a mouse model of human Barth syndrome

Frontiers in cardiovascular medicine, 2022-09, Vol.9, p.997352-997352

2022

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Liraglutide alleviates experimental diabetic cardiomyopathy in a PDH-dependent manner

Journal of endocrinology, 2024-08, Vol.262 (2)

2024

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SP1-independent inhibition of FOXM1 by modified thiazolidinediones

European journal of medicinal chemistry, 2021-01, Vol.209, p.112902, Article 112902

2021

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Ketone Ester Administration Improves Glycemia in Obese Mice

American Journal of Physiology: Cell Physiology, 2023-09, Vol.325 (3), p.C750-C757

2023

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Biodistribution and Activity of EGFR Targeted Polymeric Micelles Delivering a New Inhibitor of DNA Repair to Orthotopic Colorectal Cancer Xenografts with Metastasis

Molecular pharmaceutics, 2022-06, Vol.19 (6), p.1825-1838

2022

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233-LB: Ranolazine Fails to Improve Glycemia in Obese Liver-Specific Pyruvate Dehydrogenase–Deficient Mice

Diabetes (New York, N.Y.), 2022-06, Vol.71 (Supplement_1)

2022

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379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates

Diabetes (New York, N.Y.), 2021-06, Vol.70 (Supplement_1)

2021

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Barth syndrome-related cardiomyopathy is associated with a reduction in myocardial glucose oxidation

American journal of physiology. Heart and circulatory physiology, 2021-06, Vol.320 (6), p.H2255-H2269

2021

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207-LB: Aldose Reductase Inhibition by AT-001 Limits Diastolic Dysfunction and Adverse Remodelling in Diabetic Cardiomyopathy

Diabetes (New York, N.Y.), 2022-06, Vol.71 (Supplement_1)

2022

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The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase

Diabetes (New York, N.Y.), 2023-01, Vol.72 (1), p.126-134

2023

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A structure-activity relationship study of Forkhead Domain Inhibitors (FDI): The importance of halogen binding interactions

Bioorganic chemistry, 2019-12, Vol.93, p.103269-103269, Article 103269

2019

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118-LB: The Antipsychotic D2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA—3-Ketoacid CoA transferase

Diabetes (New York, N.Y.), 2022-06, Vol.71 (Supplement_1)

2022

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Pyruvate Dehydrogenase as a Therapeutic Target for Nonalcoholic Fatty Liver Disease

ACS pharmacology & translational science, 2021-04, Vol.4 (2), p.582-588

2021

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FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity

An Isoproteic Cocoa Butter-Based Ketogenic Diet Fails to Improve Glucose Homeostasis and Promote Weight Loss in Obese Mice

Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation

The anti-anginal ranolazine does not confer beneficial actions against hepatic steatosis in male mice subjected to high-fat diet and streptozotocin-induced type 2 diabetes

The antianginal ranolazine fails to improve glycaemia in obese liver‐specific pyruvate dehydrogenase deficient male mice

Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy

FOXM1 Inhibitors as Potential Diagnostic Agents: First Generation of a PET Probe Targeting FOXM1 To Detect Triple‐Negative Breast Cancer in vitro and in vivo

Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy

Structure-Activity Relationship of N -Phenylthieno[2,3- b ]pyridine-2-carboxamide Derivatives Designed as Forkhead Box M1 Inhibitors: The Effect of Electron-Withdrawing and Donating Substituents on the Phenyl Ring

SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes

Myocardial disturbances of intermediary metabolism in Barth syndrome

The therapeutic potential of ketones in cardiometabolic disease: impact on heart and skeletal muscle

Stimulating myocardial pyruvate dehydrogenase activity fails to alleviate cardiac abnormalities in a mouse model of human Barth syndrome

Liraglutide alleviates experimental diabetic cardiomyopathy in a PDH-dependent manner

SP1-independent inhibition of FOXM1 by modified thiazolidinediones

Ketone Ester Administration Improves Glycemia in Obese Mice

Biodistribution and Activity of EGFR Targeted Polymeric Micelles Delivering a New Inhibitor of DNA Repair to Orthotopic Colorectal Cancer Xenografts with Metastasis

233-LB: Ranolazine Fails to Improve Glycemia in Obese Liver-Specific Pyruvate Dehydrogenase–Deficient Mice

379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates

Barth syndrome-related cardiomyopathy is associated with a reduction in myocardial glucose oxidation

207-LB: Aldose Reductase Inhibition by AT-001 Limits Diastolic Dysfunction and Adverse Remodelling in Diabetic Cardiomyopathy

The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase

A structure-activity relationship study of Forkhead Domain Inhibitors (FDI): The importance of halogen binding interactions

118-LB: The Antipsychotic D2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA—3-Ketoacid CoA transferase

Pyruvate Dehydrogenase as a Therapeutic Target for Nonalcoholic Fatty Liver Disease

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