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Targeting STAT3 in cancer: how successful are we?

Expert opinion on investigational drugs, 2009-01, Vol.18 (1), p.45-56

2009

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STAT3 as a target for inducing apoptosis in solid and hematological tumors

Cell research, 2008-02, Vol.18 (2), p.254-267

2008

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STAT proteins as novel targets for cancer drug discovery

Expert opinion on therapeutic targets, 2004-10, Vol.8 (5), p.409-422

Turkson, James

2004

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Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production

Nanomedicine, 2013-05, Vol.9 (4), p.558-569

2013

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Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

Redox biology, 2022-06, Vol.52, p.102317-102317, Article 102317

2022

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Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

Proceedings of the National Academy of Sciences - PNAS, 2012-06, Vol.109 (24), p.9623-9628

2012

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Stat3 controls lysosomal-mediated cell death in vivo

Nature cell biology, 2011-03, Vol.13 (3), p.303

2011

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Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.695-710

2021

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Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo

Cancer research (Chicago, Ill.), 2016-02, Vol.76 (3), p.652-663

2016

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A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes

Biochemical pharmacology, 2010-05, Vol.79 (10), p.1398-1409

2010

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Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Cell death and differentiation, 2018-11, Vol.25 (11), p.1885-1904

2018

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Proceedings of the National Academy of Sciences - PNAS, 2007-05, Vol.104 (18), p.7391-7396

2007

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Involvement of FANCD2 in Energy Metabolism via ATP5α

Scientific reports, 2017-07, Vol.7 (1), p.4921-9, Article 4921

2017

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A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062

Molecules (Basel, Switzerland), 2017-07, Vol.22 (7), p.1166

2017

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Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Oncogene, 2005-08, Vol.24 (36), p.5552-5560

2005

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Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten

Cancer research (Chicago, Ill.), 2010-03, Vol.70 (6), p.2558-2567

2010

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A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells

PloS one, 2011-05, Vol.6 (5), p.e19605

2011

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Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo

Cell death & disease, 2022-12, Vol.13 (12), p.1022-1022, Article 1022

2022

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Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

Oncogene, 2003-07, Vol.22 (27), p.4150-4165

2003

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Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells

Clinical cancer research, 2006-01, Vol.12 (1), p.11-19

2006

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Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

Molecular cancer therapeutics, 2006-03, Vol.5 (3), p.621-629

2006

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An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431

Molecules (Basel, Switzerland), 2019-01, Vol.24 (1), p.196

2019

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

Oncogene, 2002-03, Vol.21 (13), p.2000-2008

2002

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Indirubin Derivatives Inhibit Stat3 Signaling and Induce Apoptosis in Human Cancer Cells

Proceedings of the National Academy of Sciences - PNAS, 2005-04, Vol.102 (17), p.5998-6003

2005

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Targeting STAT3 in cancer: how successful are we?

STAT3 as a target for inducing apoptosis in solid and hematological tumors

STAT proteins as novel targets for cancer drug discovery

Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

Stat3 controls lysosomal-mediated cell death in vivo

Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors

Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo

A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Involvement of FANCD2 in Energy Metabolism via ATP5α

A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten

A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells

Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo

Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

Indirubin Derivatives Inhibit Stat3 Signaling and Induce Apoptosis in Human Cancer Cells

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