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Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site

Nucleic acids research, 2018-08, Vol.46 (14), p.7296-7308

2018

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Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives

ChemMedChem, 2022-12, Vol.17 (23), p.e202200301-n/a

2022

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Covalent Complex of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development

ChemMedChem, 2020-04, Vol.15 (7), p.623-631

2020

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Recent Advances in Use of Topoisomerase Inhibitors in Combination Cancer Therapy

Current topics in medicinal chemistry, 2019-01, Vol.19 (9), p.730-740

2019

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Mechanism of Type IA Topoisomerases

Molecules (Basel, Switzerland), 2020-10, Vol.25 (20), p.4769

2020

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Direct observation of topoisomerase IA gate dynamics

Nature structural & molecular biology, 2018-12, Vol.25 (12), p.1111-1118

2018

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Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I

Nucleic acids research, 2015-12, Vol.43 (22), p.11031-11046

2015

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Microbial Type IA Topoisomerase C-Terminal Domain Sequence Motifs, Distribution and Combination

International journal of molecular sciences, 2022-08, Vol.23 (15), p.8709

2022

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Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life

Cells (Basel, Switzerland), 2024-03, Vol.13 (6), p.553

2024

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Deacetylation of topoisomerase I is an important physiological function of E. coli CobB

Nucleic acids research, 2017-05, Vol.45 (9), p.5349-5358

2017

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Synthesizing topological structures containing RNA

Nature communications, 2017-03, Vol.8 (1), p.14936-14936, Article 14936

2017

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Isolation and Quantitation of Topoisomerase Complexes Accumulated on Escherichia coli Chromosomal DNA

Antimicrobial Agents and Chemotherapy, 2012-11, Vol.56 (11), p.5458-5464

2012

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Characterization of molecular interactions between Escherichia coli RNA polymerase and topoisomerase I by molecular simulations

FEBS letters, 2016-09, Vol.590 (17), p.2844-2851

2016

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Localization of Mycobacterium tuberculosis topoisomerase I C-terminal sequence motif required for inhibition by endogenous toxin MazF4

Frontiers in microbiology, 2022-12, Vol.13, p.1032320

2022

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SbcCD-Mediated Processing of Covalent Gyrase-DNA Complex in Escherichia coli

Antimicrobial Agents and Chemotherapy, 2013-10, Vol.57 (10), p.5116-5119

2013

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Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor

PloS one, 2013-04, Vol.8 (4), p.e60770

2013

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Biochemical Basis of E. coli Topoisomerase I Relaxation Activity Reduction by Nonenzymatic Lysine Acetylation

International journal of molecular sciences, 2018-05, Vol.19 (5), p.1439

2018

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Type IA Topoisomerases as Targets for Infectious Disease Treatments

Microorganisms (Basel), 2021-01, Vol.9 (1), p.86

2021

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Inhibition of Zn(II) binding type IA topoisomerases by organomercury compounds and Hg(II)

PloS one, 2015-03, Vol.10 (3), p.e0120022

2015

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Isolation and Characterization of Fungal Endophytes from Petiveria alliacea and Their Antimicrobial Activities in South Florida

Microbiology research, 2023-09, Vol.14 (3), p.1470-1482

2023

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The interaction between transport-segment DNA and topoisomerase IA-crystal structure of MtbTOP1 in complex with both G- and T-segments

Nucleic acids research, 2023-01, Vol.51 (1), p.349-364

2023

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Identification of proximal sites for unwound DNA substrate in Escherichia coli topoisomerase I with oxidative crosslinking

FEBS letters, 2017-01, Vol.591 (1), p.28-38

2017

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Changes in lipid distribution in E. coli strains in response to norfloxacin

Journal of mass spectrometry., 2015-01, Vol.50 (1), p.88-94

2015

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Metal ion and inter-domain interactions as functional networks in E. coli topoisomerase I

Gene, 2013-07, Vol.524 (2), p.253-260

2013

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The Strictly Conserved Arg-321 Residue in the Active Site of Escherichia coli Topoisomerase I Plays a Critical Role in DNA Rejoining

The Journal of biological chemistry, 2011-05, Vol.286 (21), p.18673-18680

2011

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Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site

Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives

Covalent Complex of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development

Recent Advances in Use of Topoisomerase Inhibitors in Combination Cancer Therapy

Mechanism of Type IA Topoisomerases

Direct observation of topoisomerase IA gate dynamics

Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I

Microbial Type IA Topoisomerase C-Terminal Domain Sequence Motifs, Distribution and Combination

Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life

Deacetylation of topoisomerase I is an important physiological function of E. coli CobB

Synthesizing topological structures containing RNA

Isolation and Quantitation of Topoisomerase Complexes Accumulated on Escherichia coli Chromosomal DNA

Characterization of molecular interactions between Escherichia coli RNA polymerase and topoisomerase I by molecular simulations

Localization of Mycobacterium tuberculosis topoisomerase I C-terminal sequence motif required for inhibition by endogenous toxin MazF4

SbcCD-Mediated Processing of Covalent Gyrase-DNA Complex in Escherichia coli

Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor

Biochemical Basis of E. coli Topoisomerase I Relaxation Activity Reduction by Nonenzymatic Lysine Acetylation

Type IA Topoisomerases as Targets for Infectious Disease Treatments

Inhibition of Zn(II) binding type IA topoisomerases by organomercury compounds and Hg(II)

Isolation and Characterization of Fungal Endophytes from Petiveria alliacea and Their Antimicrobial Activities in South Florida

The interaction between transport-segment DNA and topoisomerase IA-crystal structure of MtbTOP1 in complex with both G- and T-segments

Identification of proximal sites for unwound DNA substrate in Escherichia coli topoisomerase I with oxidative crosslinking

Changes in lipid distribution in E. coli strains in response to norfloxacin

Metal ion and inter-domain interactions as functional networks in E. coli topoisomerase I

The Strictly Conserved Arg-321 Residue in the Active Site of Escherichia coli Topoisomerase I Plays a Critical Role in DNA Rejoining

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