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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

Cancer research (Chicago, Ill.), 2008-05, Vol.68 (9), p.3421-3428

2008

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Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6902-6915

2008

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Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737

Cancer research (Chicago, Ill.), 2007-02, Vol.67 (3), p.1176-1183

2007

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Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models

Clinical cancer research, 2008-06, Vol.14 (11), p.3268-3277

2008

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The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo

Cancer chemotherapy and pharmacology, 2010-10, Vol.66 (5), p.869-880

2010

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Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

Molecular and Cellular Biology, 1998-08, Vol.18 (8), p.4629-4638

1998

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ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo

Molecular cancer therapeutics, 2008-10, Vol.7 (10), p.3265-3274

2008

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Structure and Function of the Core Histone N-Termini: More Than Meets the Eye

Biochemistry (Easton), 1998-12, Vol.37 (51), p.17637-17641

1998

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Hybrid Trypsinized Nucleosomal Arrays: Identification of Multiple Functional Roles of the H2A/H2B and H3/H4 N-Termini in Chromatin Fiber Compaction

Biochemistry (Easton), 1997-09, Vol.36 (38), p.11381-11388

1997

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Predicting protein druggability

Drug discovery today, 2005-12, Vol.10 (23-24), p.1675-1682

2005

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The Yeast Histone Acetyltransferase A2 Complex, but Not Free Gcn5p, Binds Stably to Nucleosomal Arrays

The Journal of biological chemistry, 2000-08, Vol.275 (32), p.24928-24934

2000

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Assembly of defined nucleosomal and chromatin arrays from pure components

Methods in Enzymology, 1999, Vol.304, p.19-35

1999

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Enhanced Transcription Factor Access to Arrays of Histone H3/H4 Tetramer· DNA Complexes in vitro: Implications for Replication and Transcription

Proceedings of the National Academy of Sciences - PNAS, 1998-10, Vol.95 (21), p.12169-12173

1998

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Gcn5p, a Transcription-related Histone Acetyltransferase, Acetylates Nucleosomes and Folded Nucleosomal Arrays in the Absence of Other Protein Subunits

The Journal of biological chemistry, 1998-12, Vol.273 (49), p.32388-32392

1998

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Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines

Molecular cancer therapeutics, 2010-03, Vol.9 (3), p.545-557

2010

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Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line

Cancer research (Chicago, Ill.), 2002-01, Vol.62 (2), p.542-546

2002

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N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7503-7506

2010

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Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice

Cancer research (Chicago, Ill.), 2002-05, Vol.62 (9), p.2637-2643

2002

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The Core Histone N-Terminal Domains Are Required for Multiple Rounds of Catalytic Chromatin Remodeling by the SWI/SNF and RSC Complexes

Biochemistry (Easton), 1999-02, Vol.38 (8), p.2514-2522

1999

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The Bcl-2 Family Inhibitor ABT-263 Shows Significant Anti-Tumor Efficacy in Models of B Cell Non-Hodgkin's Lymphoma

Blood, 2006-11, Vol.108 (11), p.825-825

2006

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The Bcl-2 Family Inhibitor ABT-263 Shows Significant but Reversible Thrombocytopenia in Mice

Blood, 2006-11, Vol.108 (11), p.1107-1107

2006

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Modulation of nucleosomal array structure and function through the core histone proteins

Tse, Christin

1998

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Nationwide Trend of Sepsis: A Comparison Among Octogenarians, Elderly, and Young Adults

Critical care medicine, 2018-06, Vol.46 (6), p.926-934

2018

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Susceptible period for cardiovascular complications in patients recovering from sepsis

Canadian Medical Association journal (CMAJ), 2018-09, Vol.190 (36), p.E1062-E1069

2018

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GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI

PloS one, 2014-09, Vol.9 (9), p.e106609-e106609

2014

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins

Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737

Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models

The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo

Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo

Structure and Function of the Core Histone N-Termini: More Than Meets the Eye

Hybrid Trypsinized Nucleosomal Arrays: Identification of Multiple Functional Roles of the H2A/H2B and H3/H4 N-Termini in Chromatin Fiber Compaction

Predicting protein druggability

The Yeast Histone Acetyltransferase A2 Complex, but Not Free Gcn5p, Binds Stably to Nucleosomal Arrays

Assembly of defined nucleosomal and chromatin arrays from pure components

Enhanced Transcription Factor Access to Arrays of Histone H3/H4 Tetramer· DNA Complexes in vitro: Implications for Replication and Transcription

Gcn5p, a Transcription-related Histone Acetyltransferase, Acetylates Nucleosomes and Folded Nucleosomal Arrays in the Absence of Other Protein Subunits

Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines

Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line

N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors

Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice

The Core Histone N-Terminal Domains Are Required for Multiple Rounds of Catalytic Chromatin Remodeling by the SWI/SNF and RSC Complexes

The Bcl-2 Family Inhibitor ABT-263 Shows Significant Anti-Tumor Efficacy in Models of B Cell Non-Hodgkin's Lymphoma

The Bcl-2 Family Inhibitor ABT-263 Shows Significant but Reversible Thrombocytopenia in Mice

Modulation of nucleosomal array structure and function through the core histone proteins

Nationwide Trend of Sepsis: A Comparison Among Octogenarians, Elderly, and Young Adults

Susceptible period for cardiovascular complications in patients recovering from sepsis

GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI

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