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Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus

PLoS biology, 2006-02, Vol.4 (2), p.e39-e39

2006

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Identification of a Novel Family of Cell-surface Proteins Expressed in Human Vascular Endothelium

The Journal of biological chemistry, 2002-11, Vol.277 (48), p.46364-46373

2002

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A Novel Secreted, Cell-surface Glycoprotein Containing Multiple Epidermal Growth Factor-like Repeats and One CUB Domain Is Highly Expressed in Primary Osteoblasts and Bones

The Journal of biological chemistry, 2004-09, Vol.279 (36), p.37485-37490

2004

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A Novel Interleukin-17 Receptor-like Protein Identified in Human Umbilical Vein Endothelial Cells Antagonizes Basic Fibroblast Growth Factor-induced Signaling

The Journal of biological chemistry, 2003-08, Vol.278 (35), p.33232-33238

2003

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Vascular MADs: Two Novel MAD-Related Genes Selectively Inducible by Flow in Human Vascular Endothelium

Proceedings of the National Academy of Sciences - PNAS, 1997-08, Vol.94 (17), p.9314-9319

1997

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Discovering and Developing Successful Cardiovascular Therapeutics: A Conversation With James N. Topper, MD, PhD

Circulation (New York, N.Y.), 2016-11, Vol.134 (20), p.1516-1518

2016

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Flow loading induces macrophage antioxidative gene expression in experimental aneurysms

Arteriosclerosis, thrombosis, and vascular biology, 2002-12, Vol.22 (12), p.2017-2022

2002

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Transforming growth factor-beta receptors localize to caveolae and regulate endothelial nitric oxide synthase in normal human endothelial cells

Biochemical journal, 2005-08, Vol.390 (Pt 1), p.199-206

2005

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Atherosclerotic vascular disease conference : Writing group III: Pathophysiology

Circulation (New York, N.Y.), 2004-06, Vol.109 (21), p.2617-2625

2004

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Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress

Proceedings of the National Academy of Sciences - PNAS, 1996-09, Vol.93 (19), p.10417-10422

1996

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The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

Cell, 1997-06, Vol.89 (7), p.1165-1173

1997

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Genetic endothelial systems biology of sickle stroke risk

Blood, 2008-04, Vol.111 (7), p.3872-3879

2008

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Inducible and selective transgene expression in murine vascular endothelium

Physiological genomics, 2002-10, Vol.11 (2), p.99-107

2002

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Gene expression profile of human endothelial cells exposed to sustained fluid shear stress

Physiological genomics, 2002-12, Vol.12 (1), p.13-23

2002

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Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications

Vascular medicine (London, England), 2004-02, Vol.9 (1), p.35-45

2004

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Transforming Growth Factor-β1 Inhibition of Macrophage Activation Is Mediated via Smad3

The Journal of biological chemistry, 2000-11, Vol.275 (47), p.36653-36658

2000

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Gene Program for Cardiac Cell Survival Induced by Transient Ischemia in Conscious Pigs

Proceedings of the National Academy of Sciences - PNAS, 2001-07, Vol.98 (16), p.9336-9341

2001

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Transforming Growth Factor-β1 Inhibits Cytokine-mediated Induction of Human Metalloelastase in Macrophages

The Journal of biological chemistry, 2000-08, Vol.275 (33), p.25766-25773

2000

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Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo

Circulation (New York, N.Y.), 1998-12, Vol.98 (22), p.2396-2403

1998

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Common genomic response in different mouse models of β-adrenergic-induced cardiomyopathy

Circulation (New York, N.Y.), 2003-12, Vol.108 (23), p.2926-2933

2003

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The egr‐1 promoter contains information for constitutive and inducible expression in transgenic mice

The FASEB journal, 2000-10, Vol.14 (13), p.1870-1872

2000

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MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells

The Journal of biological chemistry, 1999-03, Vol.274 (13), p.8797-8805

1999

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CREB Binding Protein is a Required Coactivator for Smad-Dependent, Transforming Growth Factor β Transcriptional Responses in Endothelial Cells

Proceedings of the National Academy of Sciences - PNAS, 1998-08, Vol.95 (16), p.9506-9511

1998

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TGF-β in the Cardiovascular System: Molecular Mechanisms of a Context-Specific Growth Factor

Trends in Cardiovascular Medicine, 2000-04, Vol.10 (3), p.132-137

Topper, James N

2000

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Characterization of pDJA1, a cardiac-specific chaperone found by genomic profiling of the post-ischemic swine heart

Cardiovascular research, 2003-04, Vol.58 (1), p.126-135

2003

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Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus

Identification of a Novel Family of Cell-surface Proteins Expressed in Human Vascular Endothelium

A Novel Secreted, Cell-surface Glycoprotein Containing Multiple Epidermal Growth Factor-like Repeats and One CUB Domain Is Highly Expressed in Primary Osteoblasts and Bones

A Novel Interleukin-17 Receptor-like Protein Identified in Human Umbilical Vein Endothelial Cells Antagonizes Basic Fibroblast Growth Factor-induced Signaling

Vascular MADs: Two Novel MAD-Related Genes Selectively Inducible by Flow in Human Vascular Endothelium

Discovering and Developing Successful Cardiovascular Therapeutics: A Conversation With James N. Topper, MD, PhD

Flow loading induces macrophage antioxidative gene expression in experimental aneurysms

Transforming growth factor-beta receptors localize to caveolae and regulate endothelial nitric oxide synthase in normal human endothelial cells

Atherosclerotic vascular disease conference : Writing group III: Pathophysiology

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

Genetic endothelial systems biology of sickle stroke risk

Inducible and selective transgene expression in murine vascular endothelium

Gene expression profile of human endothelial cells exposed to sustained fluid shear stress

Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications

Transforming Growth Factor-β1 Inhibition of Macrophage Activation Is Mediated via Smad3

Gene Program for Cardiac Cell Survival Induced by Transient Ischemia in Conscious Pigs

Transforming Growth Factor-β1 Inhibits Cytokine-mediated Induction of Human Metalloelastase in Macrophages

Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo

Common genomic response in different mouse models of β-adrenergic-induced cardiomyopathy

The egr‐1 promoter contains information for constitutive and inducible expression in transgenic mice

MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells

CREB Binding Protein is a Required Coactivator for Smad-Dependent, Transforming Growth Factor β Transcriptional Responses in Endothelial Cells

TGF-β in the Cardiovascular System: Molecular Mechanisms of a Context-Specific Growth Factor

Characterization of pDJA1, a cardiac-specific chaperone found by genomic profiling of the post-ischemic swine heart

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