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Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors

Bioorganic & medicinal chemistry, 2006-10, Vol.14 (20), p.6832-6846

2006

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Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (11), p.2918-2922

2005

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Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X₇ antagonists

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (11), p.3297-3300

2011

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Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.2000-2007

2006

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Discovery of trans-3,4′-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1679-1685

2006

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Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.2990-3003

2007

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Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate

Journal of medicinal chemistry, 2022-12, Vol.65 (23), p.15893-15934

2022

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Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.9495-9515

2024

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Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (21), p.5367-5370

2004

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Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3740-3744

2006

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Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2020-04, Vol.30 (7), p.126986, Article 126986

2020

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Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability

Bioorganic & medicinal chemistry letters, 2003-05, Vol.13 (9), p.1571-1574

2003

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Synthesis and evaluation of 2′-dihalo ribonucleotide prodrugs with activity against hepatitis C virus

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115208, Article 115208

2020

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Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (21), p.5371-5376

2004

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Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

Molecular cancer therapeutics, 2005-06, Vol.4 (6), p.977-986

2005

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Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (11), p.3297-3300

2011

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Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X sub(7 antagonists)

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (11), p.3297-3300

2011

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Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1 H-tetrazol-5-amine P2X 7 antagonists

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (11), p.3297-3300

2011

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A Novel Method to Create Efficient Phage Cocktails via Use of Phage-Resistant Bacteria

Applied and environmental microbiology, 2022-03, Vol.88 (6), p.e0232321-e0232321

2022

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Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk

Frontiers in immunology, 2019-04, Vol.10, p.746-746

2019

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The emerging role of exosomes in Alzheimer’s disease

Ageing research reviews, 2021-07, Vol.68, p.101321-101321, Article 101321

2021

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Sodium-calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer's disease

Scientific reports, 2022-01, Vol.12 (1), p.1537-1537, Article 1537

2022

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Multi-scale exploring the output performance mechanism in MEA with high intrinsic activity PtCo intermetallic compounds

Journal of cleaner production, 2024-01, Vol.434, p.140072, Article 140072

2024

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Gut dysbiosis impairs hippocampal plasticity and behaviors by remodeling serum metabolome

Gut microbes, 2022-12, Vol.14 (1), p.2104089-2104089

2022

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Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors

Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity

Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X₇ antagonists

Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer

Discovery of trans-3,4′-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation

Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension

Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model

Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors

Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase

Correction to “Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate”

Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability

Synthesis and evaluation of 2′-dihalo ribonucleotide prodrugs with activity against hepatitis C virus

Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors

Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists

Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X sub(7 antagonists)

Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1 H-tetrazol-5-amine P2X 7 antagonists

A Novel Method to Create Efficient Phage Cocktails via Use of Phage-Resistant Bacteria

Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk

The emerging role of exosomes in Alzheimer’s disease

Sodium-calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer's disease

Multi-scale exploring the output performance mechanism in MEA with high intrinsic activity PtCo intermetallic compounds

Gut dysbiosis impairs hippocampal plasticity and behaviors by remodeling serum metabolome

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