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Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential

International journal of molecular sciences, 2021-06, Vol.22 (13), p.6707

2021

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Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids

Platelets (Edinburgh), 2017-05, Vol.28 (4), p.333-341

2017

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Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins

Biochemical Society transactions, 2017-06, Vol.45 (3), p.719-730

2017

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The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation

The FASEB journal, 2018-07, Vol.32 (7), p.3560-3573

2018

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Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI

Haematologica (Roma), 2018-12, Vol.103 (12), p.2097-2108

2018

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An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts

Scientific reports, 2023-03, Vol.13 (1), p.3906-3906, Article 3906

2023

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The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors

International journal of molecular sciences, 2022-02, Vol.23 (5), p.2440

2022

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CLEC-2 activates Syk through dimerization

Blood, 2010-04, Vol.115 (14), p.2947-2955

2010

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LAR protein tyrosine phosphatase regulates focal adhesions through CDK1

Journal of cell science, 2016-08, Vol.129 (15), p.2962-2971

2016

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Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10

Frontiers in immunology, 2018-07, Vol.9, p.1451-1451

2018

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The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

Blood, 2009-05, Vol.113 (20), p.4942-4954

2009

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The C-type Lectin Receptors CLEC-2 and Dectin-1, but Not DC-SIGN, Signal via a Novel YXXL-dependent Signaling Cascade

The Journal of biological chemistry, 2007-04, Vol.282 (17), p.12397-12409

2007

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Quantitative Phosphoproteomics Reveals a Role for Collapsin Response Mediator Protein 2 in PDGF-Induced Cell Migration

Scientific reports, 2017-06, Vol.7 (1), p.3970-12, Article 3970

2017

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Eye-Opening Potential for Tetraspanin Tspan12 as a Therapeutic Target for Diseases of the Retinal Vasculature

Circulation (New York, N.Y.), 2017-07, Vol.136 (2), p.196-199

Tomlinson, Michael G

2017

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A Comprehensive Proteomics and Genomics Analysis Reveals Novel Transmembrane Proteins in Human Platelets and Mouse Megakaryocytes Including G6b-B, a Novel Immunoreceptor Tyrosine-based Inhibitory Motif Protein

Molecular & cellular proteomics, 2007-03, Vol.6 (3), p.548-564

2007

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Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains

Biochemical journal, 2009-01, Vol.417 (1), p.391-401

2009

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Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation

Platelets (Edinburgh), 2017-10, Vol.28 (7), p.629-642

2017

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G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2

The Journal of biological chemistry, 2008-12, Vol.283 (51), p.35419-35427

2008

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Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists

Communications biology, 2023-04, Vol.6 (1), p.376-17, Article 376

2023

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Tetraspanin microdomains: fine-tuning platelet function

Biochemical Society transactions, 2011-04, Vol.39 (2), p.518-523

2011

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The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

The Journal of biological chemistry, 2012-11, Vol.287 (47), p.39753-39765

2012

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The metalloproteinase ADAM10 requires its activity to sustain surface expression

Cellular and molecular life sciences : CMLS, 2021-01, Vol.78 (2), p.715-732

2021

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TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS

The Journal of biological chemistry, 2016-02, Vol.291 (7), p.3145-3157

2016

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ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration

The Journal of immunology (1950), 2017-07, Vol.199 (2), p.666-676

2017

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Tspan18 is a novel regulator of thrombo-inflammation

Medical microbiology and immunology, 2020-08, Vol.209 (4), p.553-564

2020

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Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential

Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids

Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins

The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation

Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI

An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts

The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors

CLEC-2 activates Syk through dimerization

LAR protein tyrosine phosphatase regulates focal adhesions through CDK1

Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

The C-type Lectin Receptors CLEC-2 and Dectin-1, but Not DC-SIGN, Signal via a Novel YXXL-dependent Signaling Cascade

Quantitative Phosphoproteomics Reveals a Role for Collapsin Response Mediator Protein 2 in PDGF-Induced Cell Migration

Eye-Opening Potential for Tetraspanin Tspan12 as a Therapeutic Target for Diseases of the Retinal Vasculature

A Comprehensive Proteomics and Genomics Analysis Reveals Novel Transmembrane Proteins in Human Platelets and Mouse Megakaryocytes Including G6b-B, a Novel Immunoreceptor Tyrosine-based Inhibitory Motif Protein

Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2

Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists

Tetraspanin microdomains: fine-tuning platelet function

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

The metalloproteinase ADAM10 requires its activity to sustain surface expression

TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS

ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration

Tspan18 is a novel regulator of thrombo-inflammation

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