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Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Journal of medicinal chemistry, 1995-09, Vol.38 (18), p.3624-3637

1995

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Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors

Journal of medicinal chemistry, 1996-06, Vol.39 (12), p.2400-2410

1996

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Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors

Journal of medicinal chemistry, 1996-11, Vol.39 (23), p.4630-4642

1996

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Cycloalkylpyranones and Cycloalkyldihydropyrones as HIV Protease Inhibitors: Exploring the Impact of Ring Size on Structure−Activity Relationships

Journal of medicinal chemistry, 1996-09, Vol.39 (20), p.4125-4130

1996

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Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors

Journal of medicinal chemistry, 1995-05, Vol.38 (11), p.1884-1891

1995

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Streptomyces cloning: useful recombinant DNA systems and a summation of cloned genes

Antimicrobial agents and chemotherapy, 1988-10, Vol.32 (10), p.1465-1471

TOMICH, P. K

1988

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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure

Journal of medicinal chemistry, 1995-10, Vol.38 (22), p.4463-4473

1995

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Mapping of Streptococcus faecalis plasmids pAD1 and pAD2 and studies relating to transposition of Tn917

Journal of Bacteriology, 1982-12, Vol.152 (3), p.1220-1230

1982

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Properties of erythromycin-inducible transposon Tn917 in Streptococcus faecalis

Journal of Bacteriology, 1980-03, Vol.141 (3), p.1366-1374

1980

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3-arylpiperidines as potentiators of existing antibacterial agents

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (14), p.1903-1906

2001

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Streptomyces cloning: possible construction of novel compounds and regulation of antibiotic biosynthetic genes

Antimicrobial agents and chemotherapy, 1988-10, Vol.32 (10), p.1472-1476

TOMICH, P. K

1988

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The Ligand Affinity of Proteins Measured by Isothermal Denaturation Kinetics

Analytical biochemistry, 2001-05, Vol.292 (1), p.40-50

2001

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Plasmid-Related Transmissibility and Multiple Drug Resistance in Streptococcus faecalis subsp. zymogenes Strain DS16

Antimicrobial Agents and Chemotherapy, 1979-06, Vol.15 (6), p.828-830

1979

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A high-throughput resonance energy transfer assay for Staphylococcus aureus DNA ligase

Analytical biochemistry, 2004-01, Vol.324 (2), p.298-300

2004

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Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (11), p.1355-1358

2001

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Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones

Bioorganic & medicinal chemistry letters, 1998-05, Vol.8 (10), p.1237-1242

1998

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Development of activity assays for high-volume evaluation of human immunodeficiency virus (HIV) protease inhibitors in rat serum : results with ditekiren

Pharmaceutical research, 1993-04, Vol.10 (4), p.562-566

1993

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Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

Journal of medicinal chemistry, 1998-08, Vol.41 (18), p.3467-3476

1998

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Simultaneous Initiation of Synthesis of Bacteriophage T4 DNA and of Deoxyribonucleotides

Proceedings of the National Academy of Sciences - PNAS, 1976-03, Vol.73 (3), p.757-761

1976

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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors

Journal of medicinal chemistry, 1994-09, Vol.37 (20), p.3200-3204

1994

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Direct Participation of dCMP Hydroxymethylase in Synthesis of Bacteriophage T4 DNA

Proceedings of the National Academy of Sciences - PNAS, 1973-08, Vol.70 (8), p.2196-2200

1973

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Synthesis and pharmacological evaluation of sulfone substituted HIV protease inhibitors

Bioorganic & medicinal chemistry letters, 1997-02, Vol.7 (4), p.399-402

1997

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Replicative bacteriophage DNA synthesis in plasmolyzed T4-infected cells: evidence for two independent pathways to DNA

Journal of Virology, 1976-10, Vol.20 (1), p.142-156

1976

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The utility of streptomycetes as hosts for gene cloning

Genetic engineering, 1990, Vol.12, p.53

1990

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Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors

Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors

Cycloalkylpyranones and Cycloalkyldihydropyrones as HIV Protease Inhibitors: Exploring the Impact of Ring Size on Structure−Activity Relationships

Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors

Streptomyces cloning: useful recombinant DNA systems and a summation of cloned genes

Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure

Mapping of Streptococcus faecalis plasmids pAD1 and pAD2 and studies relating to transposition of Tn917

Properties of erythromycin-inducible transposon Tn917 in Streptococcus faecalis

3-arylpiperidines as potentiators of existing antibacterial agents

Streptomyces cloning: possible construction of novel compounds and regulation of antibiotic biosynthetic genes

The Ligand Affinity of Proteins Measured by Isothermal Denaturation Kinetics

Plasmid-Related Transmissibility and Multiple Drug Resistance in Streptococcus faecalis subsp. zymogenes Strain DS16

A high-throughput resonance energy transfer assay for Staphylococcus aureus DNA ligase

Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition

Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones

Development of activity assays for high-volume evaluation of human immunodeficiency virus (HIV) protease inhibitors in rat serum : results with ditekiren

Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

Simultaneous Initiation of Synthesis of Bacteriophage T4 DNA and of Deoxyribonucleotides

Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors

Direct Participation of dCMP Hydroxymethylase in Synthesis of Bacteriophage T4 DNA

Synthesis and pharmacological evaluation of sulfone substituted HIV protease inhibitors

Replicative bacteriophage DNA synthesis in plasmolyzed T4-infected cells: evidence for two independent pathways to DNA

The utility of streptomycetes as hosts for gene cloning

Structure-Based Design of Nonpeptidic HIV Protease Inhibitors: The Sulfonamide-Substituted Cyclooctylpyranones

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